Results 81 to 90 of about 27,706 (210)

Safety of Artemether-Lumefantrine Exposure in First Trimester of Pregnancy: An Observational Cohort. [PDF]

, 2014
There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies ...
Abdulla, Salim, Sigilbert Mrema, Dominic Mosha, Salim Abdulla, Sevene, Esperanca, Mosha, D., Mrema, Sigilbert, Mazuguni, F., Abdulla, S., Esperanca Sevene, Blaise Genton, Mosha, Dominic, Mazuguni, Festo, Festo Mazuguni, Sevene, E., Genton, B., Genton, Blaise, Mrema, S.   +17 more
core   +1 more source

A new global strategy for the elimination of schistosomiasis

International Journal of Infectious Diseases, 2017
Mass drug administration utilising a single oral dose of 40 mg/kg of praziquantel (PZQ) has been endorsed and advocated by the World Health Organisation (WHO) for the global control and elimination of schistosomiasis.
Allen G.P. Ross, M.D., Ph.D., Thao N. Chau, M.P.H., Marianette T. Inobaya, M.Sc., Remigio M. Olveda, M.D., Yuesheng Li, M.D, Ph.D, Donald A. Harn, Ph.D.   +5 more
doaj   +1 more source

Complete Dialysis‐Free Recovery From Severe Malaria–Associated Acute Kidney Injury and Multiorgan Failure: A Case Report and Brief Literature Review

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Severe malaria remains a major cause of acute kidney injury and multiorgan failure in endemic regions, often requiring renal replacement therapy. However, access to dialysis is limited in many resource‐constrained settings, making outcomes highly dependent on early diagnosis and effective antimalarial treatment. We report a 32‐year‐old man who
Tamirat Godebo Woyimo, Amare Hailu Ashine, Mohammed Kedir Shukri, Yonas Damtew Bejiga, Ragasa Getachew, Yosef Bekele Bonsa, Rediet Girmaye, Tsion Haile Woldemariam, Adugna Lamessa   +8 more
wiley   +1 more source

Malaria transmission after artemether-lumefantrine and dihydroartemisinin-piperaquine: a randomized trial. [PDF]

, 2013
BACKGROUND: Artemisinin-based combination therapy (ACT) reduces the potential for malaria transmission, compared with non-ACTs. It is unclear whether this effect differs between ACTs.
Sauerwein, Robert W, Drakeley, Chris J, Bousema, Teun, Kavishe, R.A., Kavishe, Reginald A, Hallett, Rachel L, Mweresa, Collins K, Hermsen, C.C., Sauerwein, R.W., Shekalaghe, S., Manjurano, Alphaxard, Omar, S.A., Shekalaghe, Seif A., Sawa, Patrick, Sutherland, Colin J, Baidjoe, Amrish Y, Yussuf, R.U., Mweresa, C.K., Omar, Sabah A., Okell, L., Okell, Lucy, Hermsen, Cornelus C., Schallig, Henk DFH, Bousema, T., Manjurano, A., Baidjoe, A.Y., Mweresa, Collins K., Hallett, R.L., Beshir, Khalid B., Beshir, Khalid B, Shekalaghe, Seif A, Beshir, K.B., Drakeley, Chris J., Kavishe, Reginald A., Omar, Sabah A, Sutherland, Colin J., Yussuf, Rahma U, Sawa, P., Baidjoe, Amrish Y., Schallig, H.D., Yussuf, Rahma U., Drakeley, C., Hermsen, Cornelus C, Sutherland, C.J., Schallig, Henk D. F. H., Sauerwein, Robert W., Hallett, Rachel L.   +46 more
core   +1 more source

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Co-administered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults

, 2022
Despite repeated malaria infection, individuals living in malaria endemic areas remain vulnerable to re-infection. The Janus kinase (JAK1/2) inhibitor ruxolitinib could potentially disrupt the parasite-induced dysfunctional immune response when ...
El Gaaloul, Myriam, Kress, Anita, Wells, Timothy, van Giersbergen, Paul, McCarthy, James S, Barnes, Karen I, Abla, Nada, Chughlay, M Farouk, Griffin, Paul, Schultz, Hayley B, Tapley, Peter, Möhrle, Jörg J, Engwerda, Christian R., Reuter, Stephanie E, et al., Webster, Rebecca A   +15 more
core   +1 more source

Residual Chemical Shift Anisotropies in the Structure Determination of Small Molecules

Magnetic Resonance in Chemistry, Volume 64, Issue 3, Page 286-311, March 2026.
Plasma neutrophil elastase(ELANE) was markedly elevated in patients with alcohol use disorder, indicating a dysregulated protease‐antiprotease inflammatory balance characterised by decreased SERPINA3. ELANE showed excellent diagnostic specificity(AUC = 0.8683), supporting its potential utility as a neuroinflammatory biomarker for AUD.
Nilamoni Nath, Juan Carlos Fuentes Monteverde, Swaraj Pathak, Christian Griesinger   +3 more
wiley   +1 more source

A Comparison of Pharmacokinetics of two Tablet Formulations Containing Artemether / Lumefantrine – Quality Criteria for Malaria Treatment Assurance [PDF]

, 2012
\ud Treatment of non-severe malaria remains a challenge to endemic areas including Tanzania. Since November 2006, Coartem® an artemisinin based combination therapy (ACT) containing artemether-lumefantrine (ALu), replaced sulphadoxine/pyrimethamine (SP ...
Alphonce, Ignace
core  

Health worker performance in the management of paediatric fevers following in-service training and exposure to job aids in Kenya. [PDF]

, 2010
BACKGROUND: Improving the way artemether-lumefantrine (AL) is provided to patients attending clinics is critical to maximize the benefit of this new medicine.
Zurovac, D, Snow, RW, Snow Robert W, Snow, Robert W., Zurovac Dejan, Webster, Jayne, Wasunna, B, Snow, Robert, Wasunna Beatrice, Jones Caroline, Bruce, J, Zurovac, Dejan, Webster Jayne, Jones, C, Jones, Caroline, Snow, Robert W, Wasunna, Beatrice, Bruce Jane, Webster, J, Bruce, Jane   +19 more
core   +1 more source

Population pharmacokinetics of lumefantrine in pregnant and non‐pregnant women with uncomplicated Plasmodium falciparum malaria in Western Kenya

British Journal of Clinical Pharmacology, Volume 92, Issue 3, Page 911-921, March 2026.
Aim This study intends to assess the pharmacokinetic properties and treatment response of lumefantrine in pregnant and non‐pregnant women with uncomplicated Plasmodium falciparum malaria infection in Western Kenya. Methods Seventy‐five women with uncomplicated P.
Elizabeth Juma, Junjie Ding, Martin Ongas, Nelly Koskei, Kevin Onyango, Florence Oloo, Rashid Aman, Gilbert Kokwaro, Joel Tarning, Bernhards Ogutu   +9 more
wiley   +1 more source

Malaria drug shortages in Kenya: a major failure to provide access to effective treatment. [PDF]

, 2009
A key bench mark of successful therapeutic policy implementation, and thus effectiveness, is that the recommended drugs are available at the point of care.
Zurovac, D, Kangwana, Beth B, Snow, RW, Njogu, Julius, Kedenge, Sarah V, Kedenge, SV, Wasunna, B, Njogu, J, Snow, Robert, Kangwana, BB, Zurovac, Dejan, Memusi, Dorothy N, Goodman, Catherine A, Goodman, CA, Snow, Robert W, Wasunna, Beatrice, Memusi, DN   +16 more
core   +1 more source