Results 71 to 80 of about 27,706 (210)

Activity of the artemether in experimental schistosomiasis mansoni

Memorias do Instituto Oswaldo Cruz, 1991
The action of the ether artemisinin (artemether) on Shistosoma mansoni in mice and the hansters experimentally infected with the LE strain was studied. In mice, the drugs showed high schistosomicidal activity using a single intramuscular dose of 100 mg ...
Neusa Araújo, Anna Kohn, Naftale Katz
doaj   +1 more source

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria in the setting of three different chemopreventive regimens. [PDF]

, 2015
BACKGROUND: The burden of malaria remains high for children in parts of Africa despite the use of insecticide-treated bed nets (ITNs). Chemoprevention has the potential of reducing the malaria burden; however, limited data exist on the efficacy and ...
Tamara Clark, Grant Dorsey, Achan, Jane, Dorsey, Grant, Mwangwa, Florence, Kapisi, James, Kamya, Moses, Seyi Soremekun, Moses Kamya, Bigira, Victor, Soremekun, Seyi, Florence Mwangwa, Clark, Tamara, Kinara, Stephen, James Kapisi, Victor Bigira, Stephen Kinara, Jane Achan   +17 more
core   +1 more source

Evidence of an increased incidence of day 3 parasitaemia in Suriname: an indicator of the emerging resistance of Plasmodium falciparum to artemether

Memorias do Instituto Oswaldo Cruz, 2013
The emerging resistance to artemisinin derivatives that has been reported in South-East Asia led us to assess the efficacy of artemether-lumefantrine as the first line therapy for uncomplicated Plasmodium falciparum infections in Suriname.
Stephen GS Vreden, Jeetendra K Jitan, Rakesh D Bansie, Malti R Adhin   +3 more
doaj   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Investigate Piperaquine Exposure in Pregnant Women Using an Individualized Profile Approach

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Malaria in pregnancy poses significant risks to the mother, fetus, and neonate, necessitating effective treatment and prevention strategies. This study explored the application of an individualized (‘virtual twin’) physiologically‐based pharmacokinetic (PBPK) modeling approach to the antimalarial drug piperaquine in pregnant women.
Sonia Khier, Myriam El Gaaloul, Joel Tarning, Nada Abla   +3 more
wiley   +1 more source

The Content of African Diets is Adequate to Achieve Optimal Efficacy with Fixed-Dose Artemether-Lumefantrine: A Review of the Evidence. [PDF]

, 2008
A fixed-dose combination of artemether-lumefantrine (AL, Coartem(R)) has shown high efficacy, good tolerability and cost-effectiveness in adults and children with uncomplicated malaria caused by Plasmodium falciparum.
Nathan Mulure, Abdulla, Salim, Kokwaro, Gilbert, Salim Abdulla, Mulure, Nathan, Ndong, A, Zulfiqarali G Premji, Ndong, A., Alice Ndong, Gilbert Kokwaro, Abdulla, S., Ndong, Alice, Mulure, N., Nwaiwu, Obiyo, Premji, Zul, Nwaiwu, O., Ogutu, Bernhards, Falade, C.O., Premji, Zulfiqarali G, Falade, Catherine O, Catherine O Falade, Sagara, Issaka, Sagara, I., Obiyo Nwaiwu, Ogutu, B., Bernhards Ogutu, Premji, Z.G., Kokwaro, G., Issaka Sagara   +28 more
core   +1 more source

LIN28A blocks the EndMT process of high glucose‐induced HRMECs by stabilizing SIRT6 mRNA

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 739-750, May 2026.
LIN28A promotes mRNA stability of SIRT6 to activate the AMPK signaling, thereby inhibiting the EndMT process induced by HG in HRMECs. ABSTRACT Background Diabetic retinopathy (DR) is a microvascular condition resulting from microangiopathy, causing gradual retinal damage and potential blindness.
Xueying Wang, Zixu Huang, Xiaohui Kuang, Yali Nan, Zhiwen Zhang, Zongming Song   +5 more
wiley   +1 more source

Implementation of artemether-lumefantrine treatment policy for malaria at health facilities in Tanzania [PDF]

, 2011
V Mugoyela1, O Minzi21Department of Medicinal Chemistry, 2Unit of Pharmacology and Therapeutics, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar Es Salaam, TanzaniaBackground: The purpose of this study was to compare knowledge
Mugoyela V, Minzi 0, Veronica Mugoyela, Omary Minzi   +3 more
core   +1 more source

A meta-analysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria.

, 2001
We conducted a meta-analysis using individual patient data from randomized controlled trials comparing artemether and quinine in severe falciparum malaria. Eleven trials were identified, of which 8 were clearly randomized.
Artemether-Quinine Meta-analysis Study Group
core   +1 more source

Prospective evaluation of artemether-lumefantrine for the treatment of non-falciparum and mixed-species malaria in Gabon [PDF]

, 2012
Background: The recommendation of artemisinin combination therapy (ACT) as first-line treatment for uncomplicated falciparum malaria is supported by a plethora of high quality clinical trials.
Mesküre Capan, Kurth, Florian Michael, Michael Ramharter, Kurth, F., Capan, Mesküre, Fanny Joanny, Arti Basra, Mombo-Ngoma, G., Capan, M., Capan Melser, Mesküre, Adegnika, A.A., Florian Kurth, Adegnika, Ayôla Akim, Adegnika, Ayola A., Ayola A Adegnika, Kremsner, Peter, Diop, D.A., Kremsner, P.G., Würbel, Heike, Kleine, C., Basra, Arti, Kleine, Christian, Ghyslain Mombo-Ngoma, Sabine Bélard, Joanny, F., Ramharter, M., Heike Würbel, Benjamin Mordmüller, Joanny, Fanny, Mombo-Ngoma, Ghyslain, Peter G Kremsner, Akerey-Diop, Daisy, Kremsner, Peter G., Daisy A Diop, Wurbel, H., Mordmüller, Benjamin Gottlieb, Christian Kleine, Belard, S., Ramharter, Michael, Basra, A., Bélard, Sabine, Kurth, Florian, Diop, Daisy A., Mordmuller, B.   +43 more
core   +1 more source