Results 61 to 70 of about 28,065 (211)

Activity of the artemether in experimental schistosomiasis mansoni

Memorias do Instituto Oswaldo Cruz, 1991
The action of the ether artemisinin (artemether) on Shistosoma mansoni in mice and the hansters experimentally infected with the LE strain was studied. In mice, the drugs showed high schistosomicidal activity using a single intramuscular dose of 100 mg ...
Neusa Araújo, Anna Kohn, Naftale Katz
doaj   +1 more source

Short‐Course Low‐Dose Primaquine for Radical Cure in G6PD‐Normal Patients in the Pre‐Elimination Context of Nepal

Tropical Medicine &International Health, Volume 31, Issue 8, Page 1028-1034, August 2026.
ABSTRACT Background Plasmodium vivax remains a challenge for malaria elimination in Nepal due to its ability to relapse. Radical cure with primaquine is effective but limited by poor adherence to the standard 14‐day low‐dose regimen. In 2022, the WHO recommended administering the same total dose (3.5 mg/kg) over 7 days to improve adherence.
Prakash Ghimire, Gokarna Dahal, Nabaraj Adhikari, Komal Raj Rijal, Sanjib Adhikari, Megha Raj Banjara, Hellen Mnjala, Grant Lee, Sophie Weston, Angela Rumaseb, Anjana Rai, Benedikt Ley, Mohammad Sharif Hossain, Julie A. Simpson, Megha Rajasekhar, Bipin Adhikari, Ric N. Price, Bibek K. Lal, Kamala Thriemer   +18 more
wiley   +1 more source

Evidence of an increased incidence of day 3 parasitaemia in Suriname: an indicator of the emerging resistance of Plasmodium falciparum to artemether

Memorias do Instituto Oswaldo Cruz, 2013
The emerging resistance to artemisinin derivatives that has been reported in South-East Asia led us to assess the efficacy of artemether-lumefantrine as the first line therapy for uncomplicated Plasmodium falciparum infections in Suriname.
Stephen GS Vreden, Jeetendra K Jitan, Rakesh D Bansie, Malti R Adhin   +3 more
doaj   +1 more source

Gossypiboma‐Induced Acute Abdomen Highlighting the Importance of Surgical Safety Protocols: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Gossypiboma, the medical term for a retained surgical sponge, is a rare but serious postoperative complication, accounting for nearly 50% of malpractice claims related to retained foreign bodies. Despite its importance, it is often underreported due to medicolegal concerns.
Priyanka Panwar, Jack Okumu, Daisy Denga, James Kariuki, O. W. Sibuor   +4 more
wiley   +1 more source

The effects of artemether, shRNA-VCAM-1 and artemether combined with shRNA-VCAM-1 on the expression of p-Akt.

, 2013
(A) U87 cells were treated with artemether (300 µmol/L) and shRNA-VCAM-1 alone or in combination. (B) Statistical analysis. The expression of p-Akt was checked with Western Blot. p-Akt was significantly inhibited in artemether and artemether+shRNA-VCAM-1
Yi Hu (58993), Yi-Xue Xue (321473), Ying-Bin Wang (101805), Yun-Hui Liu (401748), Ping Wang (42415), Yi-Long Yao (401747), Bo Yu (241082), Zhen Li (49109)   +7 more
core   +1 more source

Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria in the setting of three different chemopreventive regimens. [PDF]

, 2015
BACKGROUND: The burden of malaria remains high for children in parts of Africa despite the use of insecticide-treated bed nets (ITNs). Chemoprevention has the potential of reducing the malaria burden; however, limited data exist on the efficacy and ...
Tamara Clark, Grant Dorsey, Achan, Jane, Dorsey, Grant, Mwangwa, Florence, Kapisi, James, Kamya, Moses, Seyi Soremekun, Moses Kamya, Bigira, Victor, Soremekun, Seyi, Florence Mwangwa, Clark, Tamara, Kinara, Stephen, James Kapisi, Victor Bigira, Stephen Kinara, Jane Achan   +17 more
core   +1 more source

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Co-administered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults

, 2022
Despite repeated malaria infection, individuals living in malaria endemic areas remain vulnerable to re-infection. The Janus kinase (JAK1/2) inhibitor ruxolitinib could potentially disrupt the parasite-induced dysfunctional immune response when ...
El Gaaloul, Myriam, Kress, Anita, Wells, Timothy, van Giersbergen, Paul, McCarthy, James S, Barnes, Karen I, Abla, Nada, Chughlay, M Farouk, Griffin, Paul, Schultz, Hayley B, Tapley, Peter, Möhrle, Jörg J, Engwerda, Christian R., Reuter, Stephanie E, et al., Webster, Rebecca A, Anita Kress, Griffin, P., Rebecca A. Webster, Peter Tapley, Nada Abla, Michelle J. Boyle, Reuter, S.E., Abla, N., Hayley B. Schultz, Webster, R.A., McCarthy, J.S., Timothy Wells, Myriam El Gaaloul, M. Farouk Chughlay, Christian R. Engwerda, Marquart, L., Stephanie E. Reuter, James S. McCarthy, van Giersbergen, P., Engwerda, C.R., Louise Marquart, Boyle, M.J., Barber, B.E., Barnes, K.I., Tapley, P., Kress, A., Stephan Chalon, Schultz, H.B., Bridget E. Barber, Karen I. Barnes, El Gaaloul, M., Paul van Giersbergen, Jörg J. Möhrle, Paul Griffin, Mohrle, J.J., Chalon, S., Wells, T., Chughlay, M.F.   +53 more
core   +1 more source

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, Volume 13, Issue 27, 13 May 2026.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1179-1194, May 2026.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Microbial transformation of artemether.

, 2013
Microbial transformation of artemether.
Liwang Cui (82978), Zhen Cao (30837), Wei Zhang (405), Guiyu Tan (484227), Yongliang Cui (484225), Rui Zhang (13940), Suqin Guo (484224), Lishan He (484226), Liang Zhang (41392), Baomin Wang (174006)   +9 more
core   +1 more source