Results 41 to 50 of about 27,706 (210)

New Uses for Old Drugs: The Tale of Artemisinin Derivatives in the Elimination of Schistosomiasis Japonica in China

Molecules, 2014
Artemisinin (qinghaosu), extracted from the Chinese herb Artemisia annua L. in 1972, and its three major derivatives—artemether, artesunate and dihydroartemisinin—were firstly identified as antimalarials and found active against all species of the ...
Yi-Xin Liu, Wei Wu, Yue-Jin Liang, Zu-Liang Jie, Hui Wang, Wei Wang, Yi-Xin Huang   +6 more
doaj   +1 more source

Coartem: the Journey to the Clinic. [PDF]

, 2009
Artemisinin, from which the artemether component of Coartem (artemether/lumefantrine, AL) is derived, is obtained from the plant sweet wormwood (Artemisia annua) which has been used for over 2,000 years as a Chinese herbal remedy.
Premji, Zulfiqarali G, Premji, Z.G., Premji, Zul   +2 more
core   +1 more source

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. [PDF]

, 2007
OBJECTIVES: To compare the efficacy and safety of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for treating uncomplicated falciparum malaria in Uganda. DESIGN: Randomized single-blinded clinical trial.
Staedke Sarah G, Wabwire-Mangen, F, Yeka Adoke, Rwakimari, JB, Dorsey, Grant, Rwakimari John B, Nosten François, Talisuna, Ambrose O, Dorsey Grant, Kamya, MR, Greenhouse Bryan, Rosenthal, PJ, Greenhouse, B, Rosenthal Philip J, Staedke, SG, Nosten, F, Lugemwa, Myers, Rosenthal, Philip J, Yeka, Adoke, Dorsey, G, Staedke, Sarah G, Greenhouse, Bryan, Rwakimari, John B, Bukirwa, H, Bukirwa, Hasifa, Lugemwa, M, Kamya Moses R, Lugemwa Myers, Kamya, Moses R, Bukirwa Hasifa, Wabwire-Mangen Fred, Talisuna Ambrose O, Wabwire-Mangen, Fred, Talisuna, AO, Nosten, François, Yeka, A   +35 more
core   +1 more source

Exploring the glucose-lowering and anti-inflammatory immune mechanism of artemether by AMPK/mTOR pathway and microbiome based on multi-omics

Frontiers in Pharmacology
BackgroundDiabetes mellitus (DM) is a metabolic disease with high morbidity, which significantly affects human life and health expenditures. Previous studies have demonstrated that artemether (ATM) has anti-diabetes and anti-inflammation activities, but ...
Tao Jiang, Peipei Du, Dongxia Liu, Hetao Chen, Yujin Ma, Bin Hu, Jingna Li, Hongwei Jiang, Xuejiao Li   +8 more
doaj   +1 more source

Ultrastructural alterations in adult Schistosoma mansoni caused by artemether

Memorias do Instituto Oswaldo Cruz, 2002
Progress has been made over the last decade with the development and clinical use of artemether as an agent against major human schistosome parasites.
Shuhua Xiao, Binggui Shen, Jürg Utzinger, Jacques Chollet, Marcel Tanner   +4 more
doaj   +1 more source

Adherence to and acceptability of artemether-lumefantrine as first-line anti-malarial treatment: evidence from a rural community in Tanzania. [PDF]

, 2010
\ud \ud Controlled clinical trials have shown that a six-dose regimen of artemether-lumefantrine (AL) therapy for uncomplicated Plasmodium falciparum malaria results in cure rates >95% with good tolerability.
Abdunoor M Kabanywanyi, Nathan Mulure, King'eng'ena, Said, Kabanywanyi Abdunoor M, Mulure, Nathan, Christian Lengeler, Prudensiana Kasim, Schlienger, Raymond, Raymond Schlienger, King'eng'ena S.,, Lengeler Christian, Blaise Genton, Mulure, N., Lengeler, C., Genton, Blaise, Lengeler, Christian, Genton Blaise, Kasim Prudensiana, Kasim, Prudensiana, Kabanywanyi, A. M., King'eng'ena Said, Schlienger Raymond, Mulure Nathan, Kabanywanyi, Abdunoor M, Schlienger, R., Said King'eng'ena, Genton, B., Kasim, P.   +27 more
core   +1 more source

Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Hartono Candra, Xue‐Jiao Wang, Ka Diam Go, Li Feng, Miaomiao Cai, Guang‐Lei Ma, Clarissa Widyantoro, Lik Tong Tan, Zbynek Bozdech, Zhe Wang, Zhao‐Xun Liang   +10 more
wiley   +2 more sources

Antimalarial Drugs Enhance the Cytotoxicity of 5-Aminolevulinic Acid-Based Photodynamic Therapy against the Mammary Tumor Cells of Mice In Vitro

Molecules, 2019
Artemisinin and its derivatives, including artesunate (ART) and artemether (ARM), exert anticancer effects in the micromolar range in drug and radiation-resistant cell lines.
Tomohiro Osaki, Kiwamu Takahashi, Masahiro Ishizuka, Tohru Tanaka, Yoshiharu Okamoto   +4 more
doaj   +1 more source

Development of a specific monoclonal antibody-based ELISA to measure the artemether content of antimalarial drugs. [PDF]

PLoS ONE, 2013
Artemether is one of the artemisinin derivatives that are active ingredients in antimalarial drugs. Counterfeit and substandard antimalarial drugs have become a serious problem, which demands reliable analytical tools and implementation of strict ...
Suqin Guo, Yongliang Cui, Lishan He, Liang Zhang, Zhen Cao, Wei Zhang, Rui Zhang, Guiyu Tan, Baomin Wang, Liwang Cui   +9 more
doaj   +1 more source

Age‐Related and Seasonal Variation in Malaria and Other Causes of Fever and Their Association With Clinical Outcomes in Southern Angola: A Hospital‐Based Study

Tropical Medicine &International Health, Volume 31, Issue 9, Page 1273-1283, September 2026.
ABSTRACT Background Acute febrile illnesses in sub‐Saharan Africa are often attributed to malaria, yet many patients test negative for malaria parasites. The aetiology of nonmalarial fevers remains understudied. Here, we examine likely causes of febrile illnesses and their association with poor clinical outcomes in Angola.
Helga E. M. Gonçalves, Maria Lina Antunes, Jorge Seixas, Marcelo U. Ferreira   +3 more
wiley   +1 more source