Results 31 to 40 of about 27,706 (210)

APOPTOTIC AND VASCULAR CHANGES IN TRICHINELLA SPIRALIS IN FECTED MICE AFTER PARENTERAL ARTEMETHER TREATMENT [PDF]

Journal of the Egyptian Society of Parasitology, 2019
Trichinosis is a parasitic disease, caused by a nematode worm of the genus Trichinella. Infection is caused by ingestion of undercooked contaminated meat with infective parasitic larvae.
ASMAA MOHAMED, TAHANI FARAG, MOHAMED SARHAN, SHEREEN IBRAHIM   +3 more
doaj   +1 more source

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. [PDF]

, 2012
BACKGROUND: Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins.
Rosalba Lepore, LEPORE, ROSALBA, Pillai, DR, Via Allegra, K. Khairnar, Khairnar Krishna, Rachel Lau, Pillai Dylan R, D. R. Pillai, VIA, ALLEGRA, Dylan R Pillai, Henry M Staines, Krishna Sanjeev, S. Krishna, Lau, R, Khairnar, K, Lau Rachel, Via, A, Staines, HM, H. M. Staines, Krishna, S, Sanjeev Krishna, Krishna Khairnar, Lepore, R, Allegra Via, R. Lau, Lepore Rosalba, Staines Henry M   +27 more
core   +1 more source

Population pharmacokinetics of artemether-lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria. [PDF]

Br J Clin Pharmacol
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Ding J, Hoglund RM, van der Pluijm RW, Callery JJ, Peto TJ, Tripura R, Das S, Châu NH, Promnarate C, Mukaka M, Dysoley L, Fanello C, Onyamboko MA, Anvikar AR, Mayxay M, Smithuis F, von Seidlein L, Dhorda M, Amaratunga C, Faiz MA, Nghia HDT, White NJ, Day NPJ, Dondorp AM, Tarning J.   +24 more
europepmc   +2 more sources

Exploration of in Vivo Efficacy of Artemether-Lumefantrine Against Uncomplicated Plasmodium Falciparum Malaria in Under Fives in Tabora Region, Tanzania. [PDF]

, 2013
Tanzania adopted artemether-lumefantrine (AL) as first-line drug for uncomplicated malaria in 2006. Recently, there was an anecdotal report on high malaria recurrence rate following AL treatment in in the (urban and peri-urban), western part of Tanzania.
Minzi, O.M.S., Abdunoor M Kabanywanyi, Kabanywanyi, A.M., Mugittu, K., Joseph, Deokary, Premji, Zulfiqarali, Mugittu, Kefas, Deokary Joseph, Omary MS Minzi, Kabanywanyi, Abdunoor M, Kefas Mugittu, Ruth Hulser, Zulfiqarali Premji, Joseph, D., Premji, Zul, Hulser, Ruth, Minzi, Omary Ms, Hulser, R.   +17 more
core   +1 more source

Optimizing derivatization conditions using an experimental design and simultaneous estimation of artemether and lumefantrine by ratio first order derivative spectrophotometric method

Journal of Taibah University for Science, 2017
Artemether–lumefantrine is the most widely used artemisinin-based combination therapy for malaria. The present work aims to develop and validate a simple, accurate, precise and rapid ratio first order derivative spectrophotometric method for the ...
Jenee Christian, Purvi Shah, Margi Patel, Kalpana Patel, Tejal Gandhi   +4 more
doaj   +1 more source

Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria : a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data [PDF]

, 2015
Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well with artemether-lumefantrine efficacy.
Mårtensson, A, Sibley, CH, Nsanzabana, C, Bassat, Q, Ringwald, P, Faucher, JF, WorldWide Antimalarial Resistance Network Lumefantrine PK/PD Stu,, Ashley, EA, Hodel, EM, Lindegardh, NL, Davis, TME, Schramm, B, Lefèvre, G, Parikh, S, Mayxay, M, Van Vugt, M, Borrmann, S, McGready, R, Hamed, K, Jullien, V, Workman, LJ, Newton, PN, Stepniewska, K, Vugt, MV, Genton, B, Kiechel, JR, Rombo, L, White, Nicholas, Price, Richard, Kofoed, PE, Piola, P, Barnes, KI, Dahal, P, Aweeka, F, Moreira, C, Tarning, J, Nosten, F, Djimde, AA, Ursing, J, Ngasala, BE, Deloron, P, Karunajeewa, HA, Guérin, PJ, Denis, MB, Marsh, K, WorldWide Antimalarial Resistance Network (WWARN) Lumefantrine PK/PD Study Group, Price, RN, Lindegardh, N, White, NJ, Huang, L, McGready, Rose   +50 more
core   +1 more source

Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi [PDF]

, 2009
Sulphadoxine-pyrimethamine (SP) is the only single dose therapy for uncomplicated malaria, but there is widespread resistance. At the time of this study, artemether-lumefantrine (AL) and chlorproguanil-dapsone (CPD), both multi-dose regimes, were ...
Hughes Dyfrig A, Mavuto Mukaka, Montgomery, Jacqui, Peter A Winstanley, Wootton, Dan, Winstanley Peter A, David G Lalloo, Molyneux Malcolm E, Bell, David J., Ward, Steve, Ward, Steve A., Chimpeni Phillips, Mukaka, Mavuto, Dyfrig A Hughes, Hughes, Dyfrig A., Steve A Ward, Wootton, Daniel G., Molyneux, Malcolm E., Lalloo David G, Phillips Chimpeni, Malcolm E Molyneux, Bell David J, Kayange Noel, Jacqui Montgomery, Ward Steve A, David J Bell, Noel Kayange, Mukaka Mavuto, Hughes, Dyfrig, Kayange, Noel, Lalloo, David G., Wootton Dan, Lalloo, David; id_orcid, Chimpeni, Phillips, Winstanley, Peter, Montgomery Jacqui, Dan Wootton, Winstanley, Peter A.   +37 more
core   +1 more source

Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. [PDF]

, 2006
OBJECTIVES: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. DESIGN: Randomized single-blind controlled trial.
Staedke Sarah G, Rosenthal, Philip J, Yeka, Adoke, Banek, Kristin, Yeka Adoke, Dorsey, Grant, Staedke, Sarah G, Bakyaita Nathan, Dorsey Grant, Banek Kristin, Bukirwa, Hasifa, Talisuna Ambrose, Rosenthal Philip J, Talisuna, Ambrose, Rwakimari, John Bosco, Kamya Moses R, Kamya, Moses R, Bukirwa Hasifa, Wabwire-Mangen Fred, Bakyaita, Nathan, Wabwire-Mangen, Fred, Rwakimari John Bosco   +21 more
core   +1 more source

Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis

Parasites & Vectors, 2011
Background Praziquantel has been used as first-line drug for chemotherapy of schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also been used for the control of this infectious disease since late 1990s.
Zhao Qin-Ping, Guo Yi, Dong Hui-Fen, Liu Rong, Jiang Ming-Sen   +4 more
doaj   +1 more source

Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda. [PDF]

, 2006
BACKGROUND: A six-dose antimalarial regimen of artemether-lumefantrine (A/L) may soon become one of the most widely used drug combination in Africa, despite possible constraints with adherence and poor absorption due to inadequate nutrition, and a lack ...
Bajunirwe, Francis, Piola, P, Piola, Patrice, Taylor, W R J, Babigumira, J, Kyomuhendo, J, Taylor, Walter R. J., Checchi, Francesco, Babigumira, Joseph, Ruzagira, E, Kyomuhendo, Juliet, Taylor, Walter RJ, Ferradini, Laurent, Kiguli, James, Kiguli, J, Ferradini, L, Fogg, C, Fogg, Carole, Bajunirwe, F, Guthmann, J P, Ruzagira, Eugene, Biraro, S, Kigozi, Isaac, Checchi, F, Guthmann, Jean-Paul, Biraro, Samuel, Grandesso, Francesco, Grandesso, F, Kigozi, I, Kyomuhendo Juliet, Laurent Ferradini, Francis Bajunirwe, Walter RJ Taylor, Carole Fogg, Eugene Ruzagira, Isaac Kigozi, Taylor Walter RJ, Ruzagira Eugene, Biraro Samuel, Piola Patrice, Fogg Carole, Francesco Checchi, Samuel Biraro, Babigumira Joseph, Kigozi Isaac, James Kiguli, Grandesso Francesco, Joseph Babigumira, Kiguli James, Jean-Paul Guthmann, Ferradini Laurent, Patrice Piola, Guthmann Jean-Paul, Francesco Grandesso, Checchi Francesco, Juliet Kyomuhendo, Bajunirwe Francis   +56 more
core   +1 more source