Results 11 to 20 of about 28,065 (211)

Quality Assessment of Artemether-Lumefantrine Samples and Artemether Injections Sold in the Cape Coast Metropolis [PDF]

Journal of Tropical Medicine, 2016
Most prescribers and patients in Ghana now opt for the relatively expensive artemether/lumefantrine rather than artesunate-amodiaquine due to undesirable side effects in the treatment of uncomplicated malaria.
James Prah, Elvis Ofori Ameyaw, Richmond Afoakwah, Patrick Fiawoyife, Ernest Oppong-Danquah, Johnson Nyarko Boampong   +5 more
doaj   +2 more sources

Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrine [PDF]

Malaria Journal, 2010
Background Artemether-lumefantrine is one of the most widely used anti-malarial drug combinations in the world with excellent tolerability and cure rates in adult and paediatric patients with uncomplicated falciparum malaria. The aim of this study was to
Tarning Joel, Najmi Muzammil H, Ali Shabana, Lindegardh Niklas   +3 more
doaj   +2 more sources

Severe <i>Plasmodium vivax</i> Malaria Complicated by Secondary Hemophagocytic Lymphohistiocytosis, Disseminated Intravascular Coagulation, and Acute Pancreatitis: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Plasmodium vivax (P. vivax) malaria, once regarded as a comparatively benign infection, is increasingly recognized as a cause of severe, potentially life‐threatening multisystem disease. Concurrent secondary hemophagocytic lymphohistiocytosis (HLH), disseminated intravascular coagulation (DIC), and acute pancreatitis complicating P.
Nafian T, Azad MAK, Murshed KM, Aftab KA, Shahriar R, Faisal AA.   +5 more
europepmc   +2 more sources

Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria : a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data [PDF]

, 2015
Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well with artemether-lumefantrine efficacy.
Mårtensson, A, Sibley, CH, Nsanzabana, C, Bassat, Q, Ringwald, P, Faucher, JF, WorldWide Antimalarial Resistance Network Lumefantrine PK/PD Stu,, Ashley, EA, Hodel, EM, Lindegardh, NL, Davis, TME, Schramm, B, Lefèvre, G, Parikh, S, Mayxay, M, Van Vugt, M, Borrmann, S, McGready, R, Hamed, K, Jullien, V, Workman, LJ, Newton, PN, Stepniewska, K, Vugt, MV, Genton, B, Kiechel, JR, Rombo, L, White, Nicholas, Price, Richard, Kofoed, PE, Piola, P, Barnes, KI, Dahal, P, Aweeka, F, Moreira, C, Tarning, J, Nosten, F, Djimde, AA, Ursing, J, Ngasala, BE, Deloron, P, Karunajeewa, HA, Guérin, PJ, Denis, MB, Marsh, K, WorldWide Antimalarial Resistance Network (WWARN) Lumefantrine PK/PD Study Group, Price, RN, Lindegardh, N, White, NJ, Huang, L, McGready, Rose   +50 more
core   +3 more sources

Reduction of malaria transmission to Anopheles mosquitoes with a six-dose regimen of co-artemether. [PDF]

, 2005
BACKGROUND: Resistance of malaria parasites to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) is increasing in prevalence in Africa. Combination therapy can both improve treatment and provide important public health benefits if it curbs the spread ...
Neal Alexander (18417), Colin J Sutherland (18042), Christopher J Drakeley (58257), Rosalind Coleman (18415), Targett Geoffrey A. T, Sutherland Colin J, Gijs Walraven (18413), Jawara, Musa, Coleman, Rosalind, Sam Dunyo, Musa Jawara (18412), Alexander Neal, Geoffrey A T Targett, Sutherland, Colin J, Ord Rosalynn, Musa Jawara, Coleman Rosalind, Pinder Margaret, Jawara Musa, Ord, Rosalynn, Walraven, Gijs, Targett, Geoffrey AT, Rosalynn Ord (18410), Geoffrey A. T Targett (18418), Neal Alexander, Colin J Sutherland, Sam Dunyo (58256), Rosalind Coleman, Margaret Pinder (1712), Gijs Walraven, Walraven Gijs, Drakeley, Christopher J, Alexander, Neal, Margaret Pinder, Dunyo Sam, Dunyo, Sam, Rosalynn Ord, Christopher J Drakeley, Drakeley Christopher J, Pinder, Margaret   +39 more
core   +1 more source

Solidification of Self-Emulsifying Drug Delivery Systems as a Novel Approach to the Management of Uncomplicated Malaria

Pharmaceuticals, 2022
Malaria affects millions of people annually, especially in third-world countries. The mainstay of treatment is oral anti-malarial drugs and vaccination. An increase in resistant strains of malaria parasites to most of the current anti-malarial drugs adds
Eun Bin Seo, Lissinda H. du Plessis, Joe M. Viljoen   +2 more
doaj   +1 more source

Chlorproguanil−Dapsone−Artesunate versus Artemether−Lumefantrine : a randomized, double-blind phase III trial in African children and adolescents with uncomplicated plasmodium falciparum malaria [PDF]

, 2009
Chlorproguanil−dapsone−artesunate (CDA) was developed as an affordable, simple, fixed-dose artemisinin-based combination therapy for use in Africa. This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether−
Peter A Winstanley, Pamba Allan, Guiguemdé, Robert, Stephan Duparc, Paula L Kirby, Esamai, Fabian, Ezedinachi, Emmanuel U, Ward, S.A., Umeh, Rich E., Borrmann Steffen, Winstanley Peter A., Kirby, Paula L., Kellam, Lynda, Greenwood, Brian, Ward, Stephen A, Premji, Zul, Lynda Kellam, Ezedinachi Emmanuel U., Oguche, Stephen, Owusu-Agyei, S., Stephen Oguche, Greenwood Brian, Oguche Stephen, Owusu-Agyei Seth, Winstanley, Peter A, Emmanuel U Ezedinachi, Pamba, Allan, Rich E Umeh, Greenwood, B., Umeh Rich E., Zul Premji, Kellam, L., Winstanley, P.A., Duparc, Stephan, Owusu-Agyei, Seth, Duparc Stephan, Guiguemdé Robert, Guiguemde, R., Ward, S. A., Umeh, Rich Enujioke, Allan Pamba, Ward, Steve, Fabian Esamai, Ezedinachi, Emmanuel U., Umeh, R.E., Stephen A Ward, Kellam Lynda, Premji Zul, Esamai Fabian, Duparc, S., Kirby Paula L., Sowunmi Akintunde, Kirby, Paula L, Brian Greenwood, Pamba, A., Kirby, P.L., Rénia, Laurent, Ward Stephen A., Borrmann, S., Seth Owusu-Agyei, Robert Guiguemdé, Akintunde Sowunmi, Sowunmi, Akintunde, Ezedinachi, E.U., Umeh, Rich E, Sowunmi, A., Oguche, S., Borrmann, Steffen, Esamai, F., Steffen Borrmann, Winstanley, Peter, Winstanley, Peter A.   +71 more
core   +1 more source

Antidiabetic Effect of Artemether in Db/Db Mice Involves Regulation of AMPK and PI3K/Akt Pathways

Frontiers in Endocrinology, 2020
The traditional Chinese medicine has long been used in the treatment of diabetes, one major disease threatening the public health. It has been reported that artemether exerts antidiabetic effects on type 2 diabetes in db/db mice, however the underlying ...
Xiaolin Bai, Ruixia Pei, Wen Lei, Meiyun Zhao, Jialin Zhang, Lu Tian, Junke Shang   +6 more
doaj   +1 more source

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Sibley, CH, Malmberg, M, Nsobya, SL, Lebras, J, Nsanzabana, C, Faucher, JF, Thwing, J, Somé, AF, Ogutu, B, Houzé, S, Gadalla, NB, Björkman, A, Desai, M, Schramm, B, Venkatesan, M, Oguike, M, Ménard, D, Hamour, S, Plowe, CV, Dhorda, M, Djimdé, AA, Borrmann, S, Dorsey, G, Wong, RP, Fröberg, G, Stepniewska, K, Guérin, P, Kiechel, JR, Baliraine, FN, Johnson, J, Rombo, L, Kariuki, S, Ouédraogo, JB, Ademowo, G, Kofoed, PE, Grivoyannis, A, Falade, C, Sutherland, CJ, Nzila, A, Piola, P, Zongo, I, Eshetu, T, Dahal, P, Kamugisha, E, Ngasala, B, El-Sayed, BB, Rosenthal, PJ, Nosten, F, Eyase, F, Ursing, J, Otienoburu, SD, Davis, TM, Adam, I, Kironde, F, Zeynudin, A, Checchi, F, Moriera, C, Arze, C, Berens-Riha, N, Mwai, L, Price, RN, Faucher, Jean-François, Houzé, Sandrine, Somé, A Fabrice, Sutherland, Colin, Checchi, Francesco, Berens-Riha, Nicole, Davis, Timothy ME, Björkman, Anders, Asaq Molecular Marker Study Group, Rosenthal, Philip, Eyase, Frederick, Kariuki, Simon, Mårtensson, Andreas,, Davis, Timothy, Gadalla, Nahla B, Ménard, Didier, Arze, Cesar, Djimdé, Abdoulaye A, Fröberg, Gabrielle, Ursing, Johan, Desai, Meghna, Mårtensson, Andreas, Ouédraogo, Jean-Bosco, Mwai, Leah, Kironde, Fred, Djimde, Abdoulaye, Dorsey, Grant, Johnson, Jacob, Guérin, Philippe, Somé, A. Fabrice, Oguike, Alexis Nzila Mary, LeBras, Poul-Erik Kofoed Jacques, Kofoed, Poul-Erik, Dahal, Prabin, Nzila, Alexis, Wong, Rina PM, Nsobya, Samuel L, Zongo, Issaka, Gadalla, Nahla, Dhorda, Meghna Desai Mehul, Plowe, Christopher,, Rombo, Lars,, Stepniewska, Kasia, Adam, Ishag, Price, Ric N, Rombo, Lars, Kamugisha, Erasmus, Piola, Patrice, El-Sayed, Badria, Plowe, Christopher, V, Sutherland, Colin J, Otienoburu, Sabina Dahlström, Grivoyannis, Anastasia, Malmberg, Maja, Hamour, Sally, Ogutu, Bernhards, Wong, Rina, Sibley, Carol Hopkins, Ngasala, Billy, Oguike, Mary, Venkatesan, Meera, Baliraine, Frederick N, LeBras, Jacques, El-Sayed, Badria B, Thwing, Julie, Price, Ric, Moriera, Clarissa, Kiechel, Jean-René, Nsanzabana, Christian, Rosenthal, Philip J, Ademowo, George, Falade, Catherine, Schramm, Birgit, Wong, Rina P M, Plowe, Christopher V, Eshetu, Teferi, Davis, Timothy M E, Dhorda, Mehul, Borrmann, Steffen, Nosten, Francois, Baliraine, Frederick, Zeynudin, Ahmed, Nsobya, Samuel, Martensson, A   +144 more
core   +2 more sources

Artesunate: The Best Drug in the Treatment of Severe and Complicated Malaria

Pharmaceuticals, 2010
This review summarizes progress in treating severe and complicated malaria, which are global problems, claiming at least one million lives annually, and have been accompanied by advances in our understanding of the pathogenesis of severe malaria ...
Qigui Li, Peter Weina
doaj   +1 more source