Results 21 to 30 of about 27,706 (210)

Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects. [PDF]

, 2010
BACKGROUND\ud \ud Efforts to ease administration and enhance acceptability of the oral anti-malarial artemether-lumefantrine (A-L) crushed tablet to infants and children triggered the development of a novel dispersible tablet of A-L.
Kaiser, Guenther, Abdunoor M Kabanywanyi, Abdulla, Salim, Kabanywanyi Abdunoor M, Salim Abdulla, Reynolds Christine, Nuortti Marja, Gunther Kaiser, Christine Reynolds, Gilbert Lefevre, Nuortti, Marja, Serge Fitoussi, Yeh Ching-Ming, Fitoussi Serge, Romain Sechaud, Marja Nuortti, Kaiser, Günther, Amuri, Baraka, Ubben, David, Yeh, Ching-Ming, Steve Pascoe, David Ubben, Abdulla Salim, Amuri Baraka, Pascoe Steve, Kaiser Günther, Lefèvre, Gilbert, Pascoe, Steve, Ching-Ming Yeh, Kabanywanyi, Abdunoor M, Baraka Amuri, Ubben David, Séchaud Romain, Reynolds, Christine, Séchaud, Romain, Fitoussi, Serge, Lefèvre Gilbert   +36 more
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Counterfeit and Substandard Test of the Antimalarial Tablet Riamet^® by Means of Raman Hyperspectral Multicomponent Analysis

Molecules, 2019
The fight against counterfeit pharmaceuticals is a global issue of utmost importance, as failed medication results in millions of deaths every year. Particularly affected are antimalarial tablets.
Timea Frosch, Elisabeth Wyrwich, Di Yan, Christian Domes, Robert Domes, Juergen Popp, Torsten Frosch   +6 more
doaj   +1 more source

Dispersible formulation of artemether/lumefantrine: specifically developed for infants and young children. [PDF]

, 2009
Infants and children under five years of age are the most vulnerable to malaria with over 1,700 deaths per day from malaria in this group. However, until recently, there were no WHO-endorsed paediatric anti-malarial formulations available.
Abdulla Salim, Sagara, Issaka, Abdulla, Salim, Sagara Issaka, Salim Abdulla, Issaka Sagara   +5 more
core   +2 more sources

Reduction of malaria transmission to Anopheles mosquitoes with a six-dose regimen of co-artemether. [PDF]

, 2005
BACKGROUND: Resistance of malaria parasites to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) is increasing in prevalence in Africa. Combination therapy can both improve treatment and provide important public health benefits if it curbs the spread ...
Neal Alexander (18417), Colin J Sutherland (18042), Christopher J Drakeley (58257), Rosalind Coleman (18415), Targett Geoffrey A. T, Sutherland Colin J, Gijs Walraven (18413), Jawara, Musa, Coleman, Rosalind, Sam Dunyo, Musa Jawara (18412), Alexander Neal, Geoffrey A T Targett, Sutherland, Colin J, Ord Rosalynn, Musa Jawara, Coleman Rosalind, Pinder Margaret, Jawara Musa, Ord, Rosalynn, Walraven, Gijs, Targett, Geoffrey AT, Rosalynn Ord (18410), Geoffrey A. T Targett (18418), Neal Alexander, Colin J Sutherland, Sam Dunyo (58256), Rosalind Coleman, Margaret Pinder (1712), Gijs Walraven, Walraven Gijs, Drakeley, Christopher J, Alexander, Neal, Margaret Pinder, Dunyo Sam, Dunyo, Sam, Rosalynn Ord, Christopher J Drakeley, Drakeley Christopher J, Pinder, Margaret   +39 more
core   +1 more source

Chlorproguanil−Dapsone−Artesunate versus Artemether−Lumefantrine : a randomized, double-blind phase III trial in African children and adolescents with uncomplicated plasmodium falciparum malaria [PDF]

, 2009
Chlorproguanil−dapsone−artesunate (CDA) was developed as an affordable, simple, fixed-dose artemisinin-based combination therapy for use in Africa. This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether−
Peter A Winstanley, Pamba Allan, Guiguemdé, Robert, Stephan Duparc, Paula L Kirby, Esamai, Fabian, Ezedinachi, Emmanuel U, Ward, S.A., Umeh, Rich E., Borrmann Steffen, Winstanley Peter A., Kirby, Paula L., Kellam, Lynda, Premji, Z., Greenwood, Brian, Ward, Stephen A, Premji, Zul, Lynda Kellam, Ezedinachi Emmanuel U., Oguche, Stephen, Owusu-Agyei, S., Stephen Oguche, Greenwood Brian, Oguche Stephen, Owusu-Agyei Seth, Winstanley, Peter A, Oguche, S, Emmanuel U Ezedinachi, Pamba, Allan, Rich E Umeh, Greenwood, B., Umeh Rich E., Zul Premji, Kellam, L., Winstanley, P.A., Duparc, Stephan, Owusu-Agyei, Seth, Duparc Stephan, Guiguemdé Robert, Guiguemde, R., Ward, S. A., Umeh, Rich Enujioke, Allan Pamba, Ward, Steve, Fabian Esamai, Ezedinachi, Emmanuel U., Umeh, R.E., Stephen A Ward, Kellam Lynda, Premji Zul, Esamai Fabian, Duparc, S., Kirby Paula L., Sowunmi Akintunde, Kirby, Paula L, Brian Greenwood, Pamba, A., Kirby, P.L., Rénia, Laurent, Ward Stephen A., Borrmann, S., Seth Owusu-Agyei, Robert Guiguemdé, Akintunde Sowunmi, Sowunmi, Akintunde, Ezedinachi, E.U., Umeh, Rich E, Sowunmi, A., Oguche, S., Borrmann, Steffen, Esamai, F., Steffen Borrmann, Winstanley, Peter, Winstanley, Peter A.   +73 more
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Optimization of Treatment for Polyresistant Tropical Malaria Based on Clinical and Laboratory Indices

Aktualʹnaâ Infektologiâ, 2014
It is shown clinical and laboratory efficacy of using the drug of Chinese wormwood — artemether. It is found that the application of artemether in tropical malaria of moderate to severe clinical course led to a more rapid clinical effect, and the rapid ...
V.V. Kondratyuk
doaj   +1 more source

Artemether Ameliorates Non-Alcoholic Steatohepatitis by Repressing Lipogenesis, Inflammation, and Fibrosis in Mice

Frontiers in Pharmacology, 2022
Background: Non-alcoholic fatty liver disease (NAFLD) is a widespread disease, but no recognized drug treatment exists. Previous studies have shown that artemether (Art) can ameliorate carbon tetrachloride (CCl4)–induced liver fibrosis in mice.
Jia Xu, Xiaoyun He, Xiaoyun He, Xianghui Huang, Feng Zhang, Xinxin Ren, Charles Asakiya, Yue Li, Kunlun Huang, Kunlun Huang   +9 more
doaj   +1 more source

Analytical method development and validation for simultaneous estimation of mefloquine hydrochloride and artemether in bulk drug by simultaneous equation method

Journal of Applied Pharmaceutical Research, 2020
The purpose of the research is to establish a fast, accurate, precise, and low-cost UV-Visible spectrophotometry method for the quantitative simultaneous estimation of mefloquine hydrochloride and artemether in bulk drug.
Amit Choudhary, Manish Sinha, Amar Deep Ankalgi, Kamya Goyal, Arti Devi   +4 more
doaj   +1 more source

Investigating In Vitro and Ex Vivo Properties of Artemether/Lumefantrine Double-Fixed Dose Combination Lipid Matrix Tablets Prepared by Hot Fusion

Pharmaceutics, 2021
Highly lipophilic antimalarial drugs, artemether and lumefantrine, whilst an effective fixed-dose combination treatment to lower the malarial disease burden, are therapeutically hindered by low aqueous solubility and varied bioavailability.
Christi A. Wilkins, Lissinda H. du Plessis, Joe M. Viljoen   +2 more
doaj   +1 more source

Efficacy of Artemether-Lumefantrine in Treatment of Malaria Among Under-Fives and Prevalence of Drug Resistance Markers in Igombe-Mwanza, North-Western Tanzania. [PDF]

, 2012
\ud \ud Drug resistance to anti-malarials is a major public health problem worldwide. This study aimed at establishing the efficacy of artemether-lumefantrine (ACT) in Igombe-Mwanza, north-western Tanzania after a few years of ACT use, and establish the ...
Kamugisha, Erasmus, Minde Mercy, Kataraihya Johaness, Kironde, Fred, Kamugisha Erasmus, Erasmus Kamugisha, Jing, Sun, Kongola Gilbert, Mercy Minde, Kironde Fred, Jing Sun, Swedberg, Göte, Johaness Kataraihya, Kataraihya, Johaness, Swedberg Göte, Sun Jing, Gilbert Kongola, Kongola, Gilbert, Minde, Mercy, Fred Kironde, Göte Swedberg   +20 more
core   +1 more source