Results 21 to 30 of about 28,065 (211)

α-Artemether [PDF]

Acta Crystallographica Section E Structure Reports Online, 2007
The title compound, C16H26O5, a derivative of the anti­malaria compound artesunate, consists primarily of three substituted ring systems fused together. A cyclo­hexane ring (distorted chair configuration) fused to a tetra­hydro­pyran group (normal chair) is adjacent to an oxacyclo­heptane unit containing an endoperoxide bridge, giving the mol­ecule a ...
Butcher, Ray J., Jasinski, Jerry P., Yathirajan, H. S., Bindya, S., Narayana, B.   +4 more
openaire   +2 more sources

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. [PDF]

, 2012
BACKGROUND: Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins.
Rosalba Lepore, LEPORE, ROSALBA, Pillai, DR, Via Allegra, K. Khairnar, Khairnar Krishna, Rachel Lau, Pillai Dylan R, D. R. Pillai, VIA, ALLEGRA, Dylan R Pillai, Henry M Staines, Krishna Sanjeev, S. Krishna, Lau, R, Khairnar, K, Lau Rachel, Via, A, Staines, HM, H. M. Staines, Krishna, S, Sanjeev Krishna, Krishna Khairnar, Lepore, R, Allegra Via, R. Lau, Lepore Rosalba, Staines Henry M   +27 more
core   +1 more source

Counterfeit and Substandard Test of the Antimalarial Tablet Riamet^® by Means of Raman Hyperspectral Multicomponent Analysis

Molecules, 2019
The fight against counterfeit pharmaceuticals is a global issue of utmost importance, as failed medication results in millions of deaths every year. Particularly affected are antimalarial tablets.
Timea Frosch, Elisabeth Wyrwich, Di Yan, Christian Domes, Robert Domes, Juergen Popp, Torsten Frosch   +6 more
doaj   +1 more source

Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi [PDF]

, 2009
Sulphadoxine-pyrimethamine (SP) is the only single dose therapy for uncomplicated malaria, but there is widespread resistance. At the time of this study, artemether-lumefantrine (AL) and chlorproguanil-dapsone (CPD), both multi-dose regimes, were ...
Hughes Dyfrig A, Mavuto Mukaka, Montgomery, Jacqui, Peter A Winstanley, Wootton, Dan, Winstanley Peter A, David G Lalloo, Molyneux Malcolm E, Bell, David J., Ward, Steve, Ward, Steve A., Chimpeni Phillips, Mukaka, Mavuto, Dyfrig A Hughes, Hughes, Dyfrig A., Steve A Ward, Wootton, Daniel G., Molyneux, Malcolm E., Lalloo David G, Phillips Chimpeni, Malcolm E Molyneux, Bell David J, Kayange Noel, Jacqui Montgomery, Ward Steve A, David J Bell, Noel Kayange, Mukaka Mavuto, Hughes, Dyfrig, Kayange, Noel, Lalloo, David G., Wootton Dan, Lalloo, David; id_orcid, Chimpeni, Phillips, Winstanley, Peter, Montgomery Jacqui, Dan Wootton, Winstanley, Peter A.   +37 more
core   +1 more source

Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. [PDF]

, 2006
OBJECTIVES: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. DESIGN: Randomized single-blind controlled trial.
Staedke Sarah G, Rosenthal, Philip J, Yeka, Adoke, Banek, Kristin, Yeka Adoke, Dorsey, Grant, Staedke, Sarah G, Bakyaita Nathan, Dorsey Grant, Banek Kristin, Bukirwa, Hasifa, Talisuna Ambrose, Rosenthal Philip J, Talisuna, Ambrose, Rwakimari, John Bosco, Kamya Moses R, Kamya, Moses R, Bukirwa Hasifa, Wabwire-Mangen Fred, Bakyaita, Nathan, Wabwire-Mangen, Fred, Rwakimari John Bosco   +21 more
core   +1 more source

Optimization of Treatment for Polyresistant Tropical Malaria Based on Clinical and Laboratory Indices

Aktualʹnaâ Infektologiâ, 2014
It is shown clinical and laboratory efficacy of using the drug of Chinese wormwood — artemether. It is found that the application of artemether in tropical malaria of moderate to severe clinical course led to a more rapid clinical effect, and the rapid ...
V.V. Kondratyuk
doaj   +1 more source

Analytical method development and validation for simultaneous estimation of mefloquine hydrochloride and artemether in bulk drug by simultaneous equation method

Journal of Applied Pharmaceutical Research, 2020
The purpose of the research is to establish a fast, accurate, precise, and low-cost UV-Visible spectrophotometry method for the quantitative simultaneous estimation of mefloquine hydrochloride and artemether in bulk drug.
Amit Choudhary, Manish Sinha, Amar Deep Ankalgi, Kamya Goyal, Arti Devi   +4 more
doaj   +1 more source

Artemether Ameliorates Non-Alcoholic Steatohepatitis by Repressing Lipogenesis, Inflammation, and Fibrosis in Mice

Frontiers in Pharmacology, 2022
Background: Non-alcoholic fatty liver disease (NAFLD) is a widespread disease, but no recognized drug treatment exists. Previous studies have shown that artemether (Art) can ameliorate carbon tetrachloride (CCl4)–induced liver fibrosis in mice.
Jia Xu, Xiaoyun He, Xiaoyun He, Xianghui Huang, Feng Zhang, Xinxin Ren, Charles Asakiya, Yue Li, Kunlun Huang, Kunlun Huang   +9 more
doaj   +1 more source

Investigating In Vitro and Ex Vivo Properties of Artemether/Lumefantrine Double-Fixed Dose Combination Lipid Matrix Tablets Prepared by Hot Fusion

Pharmaceutics, 2021
Highly lipophilic antimalarial drugs, artemether and lumefantrine, whilst an effective fixed-dose combination treatment to lower the malarial disease burden, are therapeutically hindered by low aqueous solubility and varied bioavailability.
Christi A. Wilkins, Lissinda H. du Plessis, Joe M. Viljoen   +2 more
doaj   +1 more source

APOPTOTIC AND VASCULAR CHANGES IN TRICHINELLA SPIRALIS IN FECTED MICE AFTER PARENTERAL ARTEMETHER TREATMENT [PDF]

Journal of the Egyptian Society of Parasitology, 2019
Trichinosis is a parasitic disease, caused by a nematode worm of the genus Trichinella. Infection is caused by ingestion of undercooked contaminated meat with infective parasitic larvae.
ASMAA MOHAMED, TAHANI FARAG, MOHAMED SARHAN, SHEREEN IBRAHIM   +3 more
doaj   +1 more source