Results 81 to 90 of about 7,063 (180)

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles. [PDF]

J Ovarian Res, 2022
Tsai TE, Lin PH, Lian PF, Li CJ, Vitale SG, Mikuš M, Su WP, Tsai HW, Tsui KH, Lin LT.   +9 more
europepmc   +1 more source

Sperm Sexing in Selected Animals and Humans: Methods, Applications, and Future Prospects

Andrology, Volume 14, Issue 5, Page 1089-1101, July 2026.
ABSTRACT Background Sperm sexing is a technique that enables the selection of offspring sex by sorting spermatozoa based on their sex chromosomes. This technology has gained increasing attention due to its potential applications in both animal breeding and human‐assisted reproduction.
Domrazek Kinga, Jurka Piotr
wiley   +1 more source

Phenylalanine Versus Tyrosine (Pos. 367/332 in MCT1/MCT4) in the Substrate Binding Site Defines Affinity and Preferred Directionality of Human Monocarboxylate Transporters 1–4

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Aim Human monocarboxylate transporters 1–4, MCT, are key for the lactate/H+ exchange between glycolytic and oxidative cancer cells, white and red muscle fibers, or in the astrocyte‐neuron shuttle. The common MCT transport mechanism involves three conserved residues, that is, a substrate‐attracting Lys and a conformation‐locking Asp/Arg salt ...
Maike Menzel, Ioana‐Daniela Dumitru, Josh Peters, Jan‐Bernd Hövener, Andrey N. Pravdivtsev, Ana‐Nicoleta Bondar, Eric Beitz   +6 more
wiley   +1 more source

Evaluation of PLCζ and PAWP Expression in Globozoospermic Individuals

Cell Journal, 2016
Objective: Globozoospermia is a rare type of teratozoospermia with incidence of 0.1% among infertile individuals. Phospholipase C zeta (PLCζ) and postacrosomal sheath WW domain binding protein (PAWP) are the main candidates in sperm taking ...
Majid Kamali-Dolat Abadi, Marziyeh Tavalaee, Abdolhossein Shahverdi, Mohammad Hossein Nasr-Esfahani   +3 more
doaj  

Reduced Mechanical Tactile Stimulation Under Space Microgravity Affects Synaptic Signaling and Contributes to Neuromuscular Aging in Caenorhabditis elegans

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Microgravity (μG) reduces mechanical tactile stimulation in Caenorhabditis elegans, causing neuromuscular decline, altered gene expression, synaptic defects, and accelerated aging phenotypes. The gentle‐touch mechanoreceptor MEC‐4 mediates μG‐induced body length reduction and extracellular matrix gene downregulation.
Atsushi Higashitani, Je‐Hyun Moon, Jong‐In Hwang, Nahoko Higashitani, Toko Hashizume, Ahmad Aisha Abu, Kazuki Ooizumi, Ibuki Sazuka, Yoshimitsu Hashizume, Masumi Umehara, Alfredo V. Alcantara Jr, Ban‐seok Kim, Timothy Etheridge, Nathaniel J. Szewczyk, Takaaki Abe, Jin I. Lee, Akira Higashibata   +16 more
wiley   +1 more source

Altered zygotic gene expression caused by sperm with Tdrd6 variants disrupts early embryonic development

MedComm
The precise mechanisms behind early embryonic arrest due to sperm‐related factors and the most effective strategies are not yet fully understood.
Zhijie Hu, Yuqi Zhang, Renfei Cai, Qiuju Chen, Haiyan Guo, Danjun Li, Weidong Lin, Hongxi He, Haibo Wu, Yali Liu, Bin Li, Qianwen Xi, Hongyuan Gao, Jian Zhang, Qifeng Lyu, Yanping Kuang, Xuefeng Lu   +16 more
doaj   +1 more source

Phospholipase C zeta and oocyte activation defects: moving toward the objective identification of patients eligible for artificial oocyte activation [PDF]

Fertility and Sterility, 2020
Rita Cássia S, Figueira, Sandro C, Esteves   +1 more
openaire   +2 more sources

Early rescue oocyte activation at 5 h post-ICSI is a useful strategy for avoiding unexpected fertilization failure and low fertilization in ICSI cycles

Frontiers in Endocrinology
IntroductionAttempts to artificially activate unfertilized oocytes at 24 h post intracytoplasmic sperm injection (ICSI) have generally resulted in poor outcomes.
Lintao Xue, Shikai Wang, Pingpin Wei, Haifang Liu, Xianbao Mao, Jie Qin, Yaoxuan Li, Xiaohui Zhang, Zhengda Li, Yueyue Huang, Liangshi Chen, Wen Shi, Liling Liu   +12 more
doaj   +1 more source

Add-On Technologies That Aim to Improve Oocyte Quality and Embryo Implantation Potential

Medicina
Advancements in assisted reproductive technologies (ARTs) have led to the development of various add-on techniques aimed at improving oocyte quality and enhancing embryo implantation potential.
Nikos Petrogiannis, Maria Filippa, Kalliopi Chatzovoulou, Savvas Petrogiannis, Ioannis Filippas, Grigoris Grimbizis, Efstratios Kolibianakis, Katerina Chatzimeletiou   +7 more
doaj   +1 more source