Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity
Advanced Science, Volume 13, Issue 16, 18 March 2026.Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu +5 more
wiley +1 more source
Predictive prioritization of genes significantly associated with biotic and abiotic stresses in maize using machine learning algorithms. [PDF]
Front Plant SciPradhan AK +3 more
europepmc +1 more source
Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design
Advanced Science, Volume 13, Issue 14, 9 March 2026.Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao +4 more
wiley +1 more source
Artificial and Bioengineered Therapeutic Options for Corneal Endothelial Disease. [PDF]
Bioengineering (Basel)Fu L +9 more
europepmc +1 more source
CRISPR Assays for Protein Detection
Chemistry–Methods, Volume 6, Issue 3, March 2026.This review summarizes recent advances in CRISPR–Cas–based strategies for protein detection. Particular focus is placed on recognition element–based approaches, in which antibodies, aptamers, or DNAzymes convert protein binding into CRISPR‐readable nucleic acid signals, and activity‐based strategies that exploit intrinsic protein functions to trigger ...
Luca Capelli +5 more
wiley +1 more source
Accurate predictions of protein mutational effects accelerated with a hybrid-topology free energy protocol. [PDF]
Commun ChemKoenekoop L +4 more
europepmc +1 more source
Transposable elements: Functional aspects and applications as drivers of crop innovation
Crop Science, Volume 66, Issue 2, March/April 2026.Abstract Transposable elements (TEs), which were once relegated to the status of genomic parasites, are today accepted as important agents of plant genome evolution and adaptation. This review integrates evidence pointing to their dual function as drivers of genetic diversity and instability, with a focus on their contribution to phenotypic innovation,
Flávia Layse Belém Medeiros +12 more
wiley +1 more source
Environmental DNA, Volume 8, Issue 2, March/April 2026.The study compared trawl and eDNA metabarcoding of demersal fish communities in an open ocean environment around the Faroe Islands. eDNA provided a comparable assessment of demersal species biomass and revealed additional spatial information on keystone species known to be under‐sampled by demersal trawls due to size and behavioral traits.
I. Salter +4 more
wiley +1 more source
FASTK post-transcriptional regulators - a 'FAST-tracK' in mitochondrial gene expression. [PDF]
Biochem Soc TransVan Riper J, Corsaro BJ, Pillon MC.
europepmc +1 more source
Passive Gauze‐Based eDNA Sampler Proves Efficient and Cost‐Effective in the Marine Environment
Environmental DNA, Volume 8, Issue 2, March/April 2026.Here, we present the first empirical comparison of the metaprobe 2.0, a low‐cost, passive eDNA sampler, against an industry standard Sterivex filtration method using dip‐collected 1‐L water samples (“water bottles”). Across 14 joint deployments, we assessed detection and quantification of eDNA of two elasmobranch and two teleost species. While Sterivex
Molly M. Kressler +5 more
wiley +1 more source