Results 121 to 130 of about 7,154 (227)

ERH promotes primary microRNA processing beyond cluster assistance. [PDF]

Nat Commun
Jang H, Park J, Kim VN.
europepmc   +1 more source

Primer Length in Reverse Transcription Determines Biodiversity Recovery and Reproducibility in eRNA Metabarcoding

Environmental DNA, Volume 8, Issue 2, March/April 2026.
Primer length for reverse transcription significantly affects eRNA‐based biodiversity recovery and community structure. Shorter primers, particularly N4 and N5, in random priming and medium‐length primers, particularly T20, in oligo(dT) priming demonstrate superior performance, especially in detecting the rare biosphere.
Fuwen Wang, Wei Xiong, Xuena Huang, Aibin Zhan   +3 more
wiley   +1 more source

Supplementary L-arginine can enhance reproductive parameters and outcomes in large mammals. [PDF]

Front Vet Sci
Ohrt MM, Ing NH.
europepmc   +1 more source

Macromolecule‐Loaded Hybrid Extracellular Vesicles via Ionic Lipid–Based Post‐Loading for Intracellular Delivery: Functional Evaluation for Neurodegenerative Therapy

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
ABSTRACT Extracellular vesicles (EVs) are natural carriers that show promise as drug delivery systems (DDS). We developed a non‐invasive post‐loading method to encapsulate macromolecules in EVs using our proprietary ionic lipid base (ILB), which enables electrostatically driver hybridisation without disrupting EV structure.
Lin Cui, Fumiyasu Ono, Tomoko Ichinose, Masahiro Goto, Kohei Ishihama   +4 more
wiley   +1 more source

Purification of ribosomes from human embryonic stem (hES) cells for high-resolution Cryo-EM structural studies. [PDF]

Front Mol Biosci
Hiregange DG, Fedorenko A, Ainbinder E, Bashan A, Yonath A.   +4 more
europepmc   +1 more source

RNA‐Based Therapies for Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri, Sonam Gurung, Roopkatha Ghosh, Philippa B. Mills, Julien Baruteau, Haiyan Zhou   +5 more
wiley   +1 more source

Technologies for Targeted RNA Degradation and Induced RNA Decay. [PDF]

Chem Rev
Mikutis S, Bernardes GJL.
europepmc   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Single-tube two-step RPA-CRISPR/Cas12b platform for detection of Pseudomonas aeruginosa. [PDF]

PLoS One
Lin H, Wang S, Xie Y, Cheng C, Jin J, Song X, Zhang H.   +6 more
europepmc   +1 more source

Early Cancer Detection: What's Going on and What's Next

MedComm, Volume 7, Issue 3, March 2026.
Multicancer early detection (MCED) platforms have emerged as a promising strategy for the safe and effective early detection of multiple cancer types, with the potential to reduce metastatic burden and improve clinical outcomes, particularly for aggressive malignancies that lack effective population‐level screening.
Emma Di Carlo
wiley   +1 more source