Results 71 to 80 of about 44,282 (308)

Environmental pollutants-dependent molecular pathways and carcinogenesis [PDF]

BioDiscovery, 2019
Exposure to environmental pollutants can modulate many biological and molecular processes such as gene expression, gene repair mechanisms, hormone production and function and inflammation, resulting in adverse effects on human health including the ...
Myriam El Helou, Pascale A. Cohen, Mona Diab-Assaf, Sandra Ghayad   +3 more
doaj   +3 more sources

Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson, April Park, Yobouet Ines Kouakou, Zoey A. Miller, Nabil F. Darwich, Nithin D. Adappa, James N. Palmer, Ryan M. Carey, Robert J. Lee   +8 more
wiley   +1 more source

Influence of Simvastatin and Interleukin 1 Receptor Antagonist on Expression of Aryl Hydrocarbon Receptors Under Experimental Acute Ileitis

Gastroenterologìa, 2015
Aryl hydrocarbon receptor (AhR) — transcription factor activated by a large number of environmental agents, and may play a role in the pathogenesis of inflammatory bowel diseases in humans and mouse models.
O.S. Zherebiatiev, O.M. Kamyshnyi
doaj   +1 more source

Dopamine is an aryl hydrocarbon receptor agonist

Biochemical Journal, 2020
Tryptophan metabolites exhibit aryl hydrocarbon receptor (AhR) agonist activity and recent studies show that the phenylalanine metabolites serotonin and carbidopa, a drug used in treating Parkinson's disease, activated the AhR. In this study, we identified the neuroactive hormone dopamine as an inducer of drug-metabolizing enzymes CYP1A1, CYP1B1, and ...
Hyejin Park, Un-ho Jin, Keshav Karki, Arul Jayaraman, Clint Allred, Sharon K. Michelhaugh, Sandeep Mittal, Robert S. Chapkin, Stephen Safe   +8 more
openaire   +2 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Using nuclear receptor activity to stratify hepatocarcinogens. [PDF]

PLoS ONE, 2011
BackgroundNuclear receptors (NR) are a superfamily of ligand-activated transcription factors that control a range of cellular processes. Persistent stimulation of some NR is a non-genotoxic mechanism of rodent liver cancer with unclear relevance to ...
Imran Shah, Keith Houck, Richard S Judson, Robert J Kavlock, Matthew T Martin, David M Reif, John Wambaugh, David J Dix   +7 more
doaj   +1 more source

Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.

Environmental Health Perspectives, 2003
Chemoprotective phytochemicals exhibit multiple activities and interact with several cellular receptors, including the aryl hydrocarbon (Ah) receptor (AhR).
Shu Zhang, C. Qin, S. Safe
semanticscholar   +1 more source

Exposure to occupational inhalants and the risk of developing rheumatoid arthritis: A systematic review and meta‐analysis

Arthritis &Rheumatology, Accepted Article.
Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint pain, swelling, and stiffness. While smoking is a well‐established risk factor for RA, the role of occupational inhalants in RA development is less well recognized.
Qianwen Liu, Xin Song, Emily Mauro, Yuan Jiang, Klementy Shchetynsky, PLars Klareskog, Lars Alfredsson, Xia Jiang   +7 more
wiley   +1 more source

Polychlorinated naphthalenes in the serum of individuals with thyroid dysfunction and their potential mechanisms of impact on disease progression

Emerging Contaminants
Polychlorinated naphthalenes (PCNs) comprise 75 congeners, with varying concentrations and major congeners across different populations. Recent studies have found a relationship between PCNs and thyroid hormone levels, suggesting they may interfere with ...
Yuhao Fan, Dan Chen, Xinyu Lou, Ye Wu, Jie Sun, Zhiyan Liu, Jun Jin, Tan Chen   +7 more
doaj   +1 more source

Gene-environment interactions in male reproductive health: special reference to the aryl hydrocarbon receptor signaling pathway

Asian Journal of Andrology, 2014
Over the last few decades, there have been numerous reports of adverse effects on the reproductive health of wildlife and laboratory animals caused by exposure to endocrine disrupting chemicals (EDCs).
Leon J S Brokken, Yvonne Lundberg Giwercman   +1 more
doaj   +1 more source