Results 71 to 80 of about 2,541 (157)

Enhancement of Radiosensitization by Silver Nanoparticles Functionalized with Polyethylene Glycol and Aptamer As1411 for Glioma Irradiation Therapy

International Journal of Nanomedicine, 2019
Jing Zhao,1 Peidang Liu,1,2 Jun Ma,3 Dongdong Li,1 Huiquan Yang,1 Wenbin Chen,1 Yaowen Jiang2 1School of Medicine, Southeast University, Nanjing 210009, People’s Republic of China; 2Jiangsu Key Laboratory for Biomaterials and Devices, Southeast ...
Zhao J, Liu P, Ma J, Li D, Yang H, Chen W, Jiang Y   +6 more
doaj  

Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1

Biochimie, 2015
During clinical trials, a number of fully characterized molecules are dropped along the way because they do not provide enough benefit for the patient. Some of them show limited side effects and might be of great use for other applications. AS1411 is a nucleolin-targeting aptamer that underwent phase II clinical trials as anticancer agent.
Metifiot, Mathieu, Amrane, Samir, Mergny, Jean-Louis, Andreola, Marie-Line   +3 more
openaire   +3 more sources

Multifunctional Theranostic Nanoparticles for Enhanced Tumor Targeted Imaging and Synergistic FUS/Chemotherapy on Murine 4T1 Breast Cancer Cell

International Journal of Nanomedicine, 2022
Zhengyue Kang,1,2,* Min Yang,1,2,* Xiaoling Feng,1,2 Hongjian Liao,1,2 Zhifei Zhang,1,2 Yonghong Du1,2 1State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing ...
Kang Z, Yang M, Feng X, Liao H, Zhang Z, Du Y   +5 more
doaj  

As1411-modified liposomes to enhance drug utilization and augment the anti-tumor efficacy

Cancer Nanotechnology
Background The utilization of liposomes in drug delivery has garnered significant attention due to their efficient drug loading capacity and excellent biocompatibility, rendering them a promising platform for tumor therapy.
Danhuan Zhang, Lingyun Chen, Yang Zhao, Hao Ni, Qiuying Quan, Jun Ma, Lingchuan Guo   +6 more
doaj   +1 more source

A pH-Sensitive I-Motif Aptamer Probe for Dual Targeting and Imaging of Pancreatic Cancer Cells via Nucleolin Interactions

Journal of Bio-X Research
This study investigates the targeted imaging and tumor inhibition effects of a “signal-off” imaging-based activatable aptamer probe (I-AAP) for pancreatic cancer.
Quwen Li, Qingquan Chen, Juan Tang, Qicai Liu, Feng Gao   +4 more
doaj   +1 more source

Preparation of AS1411 Aptamer Modified Mn-MoS2 QDs for Targeted MR Imaging and Fluorescence Labelling of Renal Cell Carcinoma

International Journal of Nanomedicine, 2019
Shaohui Zheng,1–3,* Min Zhang,2,* Hongyan Bai,2 Meijuan He,2 Lina Dong,2 Lulu Cai,2 Mingming Zhao,2 Qi Wang,2 Kai Xu,1–3 Jingjing Li1–3 1Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, People ...
Zheng S, Zhang M, Bai H, He M, Dong L, Cai L, Zhao M, Wang Q, Xu K, Li J   +9 more
doaj  

Dual-Mechanism Aptamer–Drug Complex Overcomes Paclitaxel Resistance in Ovarian Cancer via Structural Constraint and Telomerase Inhibition

Research
Paclitaxel resistance and poor tumor selectivity remain significant challenges in epithelial ovarian cancer therapy. To overcome these challenges, we engineered PSaA360, a structurally constrained aptamer–drug conjugate with a dual-functional molecular ...
Yuan Ma, Zefeng Chen, Xinyang Shen, Feng Ding, Nan Liu, Sifan Yu, Jia-Ke Xu, Hu Li, Aiping Lu, Huarui Zhang, Chuanxin Zhong, Yihao Zhang, Fangfei Li, Dong-Hua Yang, Tao Tang, Bao-Ting Zhang, Ge Zhang   +16 more
doaj   +1 more source

Novel nanosized AS1411–chitosan–BODIPY conjugate for molecular fluorescent imaging

International Journal of Nanomedicine, 2019
Setareh Taki,1 Mehdi Shafiee Ardestani21Department of Radiopharmacy, International Campus, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences ...
Taki S, Ardestani MS
doaj  

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Targeting glutamine synthetase with AS1411-modified exosome-liposome hybrid nanoparticles for inhibition of choroidal neovascularization

Journal of Nanobiotechnology
Choroidal neovascularization (CNV) is a leading cause of visual impairment in wet age-related macular degeneration (wAMD). Recent investigations have validated the potential of reducing glutamine synthetase (GS) to inhibit neovascularization formation ...
Miaomiao Zhang, Xinyue Lu, Lifu Luo, Jinqiu Dou, Jingbo Zhang, Ge Li, Li Zhao, Fengying Sun   +7 more
doaj   +1 more source