Results 131 to 140 of about 2,325 (152)

Targeted delivery of melittin to cancer cells by AS1411 anti-nucleolin aptamer

Drug Development and Industrial Pharmacy, 2018
Melittin, a small water-soluble cationic amphipathic α-helical linear peptide, consisted of 26 amino acids, is the honeybee venom major constituent. Several reports have proved the lytic and apoptotic effects of melittin in several cancerous cell lines.
Seyed Hossein, Rajabnejad, Ahad, Mokhtarzadeh, Khalil, Abnous, Seyed Mohammad, Taghdisi, Mohammad, Ramezani, Bibi Marjan, Razavi   +5 more
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Aptamer (AS1411)-Conjugated Liposome for Enhanced Therapeutic Efficacy of miRNA-29b in Ovarian Cancer

Journal of Nanoscience and Nanotechnology, 2020
AS1411 Aptamer-functionalized liposome was successfully formulated and found to be nanosized. Flow cytometer and CLSM results demonstrated that Aptamer enhanced the targeting of carrier in the cancer cells via nucleolin-mediated transmembrane endocytosis pathway.
Lanyu, Jiang, Hui, Wang, Shaozheng, Chen
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AS1411 aptamer in melanoma therapy: Harnessing targeted strategies for precision treatment

Pathology - Research and Practice
Melanoma, the fifth most prevalent cancer type in both men and women, is characterized by substantial incidence and mortality rates. Melanoma treatment varies by stage and may include surgery, chemotherapy, immunotherapy, and targeted therapies. The AS1411 aptamer, which targets the overexpressed nucleolin protein in melanoma cells, has emerged as a ...
Monireh Askarzadeh, Misagh Rajabinejad, Alireza Rafiei, Maryam Hashemi, Rezvan Yazdian-Robati   +4 more
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In silico activity of AS1411 aptamer against nucleolin of cancer cells

2021
The support of this work by the research council of Isfahan University of Medical Sciences under grant number 298096 and ethics code IR.MUI.RESEARCH.
Farahbakhsh, Z., Zamani, M. R., Rafienia, M., Gülseren, Oğuz, Mirzaei, M.   +4 more
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Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas

Biomaterials, 2014
BRAF gene mutation is found in more than 60% of malignant melanomas, which are difficult to treat. In this study, a new tumor-targeting liposome was developed to deliver anti-BRAF siRNA (siBraf) for the treatment of melanomas. Nucleolin is overexpressed on the surface of cancer cells.
Liyu, Li, Jianjun, Hou, Xinjie, Liu, Yujia, Guo, Yun, Wu, Lihe, Zhang, Zhenjun, Yang   +6 more
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Tumor targeting with a^99mTc-labeled AS1411 aptamer in prostate tumor cells

Journal of Drug Targeting, 2015
AS1411, a 26-base guanine-rich oligonucleotide aptamer, has high affinity to nucleolin, mainly on tumor cell surfaces. In this study, a modified AS1411 was labeled with (99m)Tc and evaluated as a potential tumor-targeting agent for imaging. The AS1411 aptamer was conjugated with HYNIC and labeled with (99m)Tc in the presence a co-ligand.
Zohreh, Noaparast, Seyed Jalal, Hosseinimehr, Majid, Piramoon, Seyed Mohammad, Abedi   +3 more
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AS1411, a Novel DNA Aptamer as a Potential Treatment of Acute Myelogenous Leukaemia (AML).

Blood, 2006
Abstract AS1411 (formerly AGRO100) is the first nucleic acid aptamer to enter oncology trials and is currently in a Phase I study in renal and lung patients. AS1411 is a 26mer unmodified phosphodiester-based guanosine rich oligonucleotide which, as a dimer, forms a serum-resistant quartet structure.
Kirti Shah, Hakim Djeha, Christy Richie, Grainne McGeever, Colin Green   +4 more
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AS1411 aptamer tagged PLGA‐lecithin‐PEG nanoparticles for tumor cell targeting and drug delivery

Biotechnology and Bioengineering, 2012
AbstractLiposomes and polymers are widely used drug carriers for controlled release since they offer many advantages like increased treatment effectiveness, reduced toxicity and are of biodegradable nature. In this work, anticancer drug‐loaded PLGA‐lecithin‐PEG nanoparticles (NPs) were synthesized and were functionalized with AS1411 anti‐nucleolin ...
Athulya, Aravind, Prashanti, Jeyamohan, Remya, Nair, Srivani, Veeranarayanan, Yutaka, Nagaoka, Yasuhiko, Yoshida, Toru, Maekawa, D Sakthi, Kumar   +7 more
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The effect of AS1411 aptamer on anti-tumor effects of dendrimers containing SN38

Journal of Drug Delivery Science and Technology, 2022
Kiana Sherkat Sadi, Asma Mahmoudi, Mahmoud Reza Jaafari, Seyedeh Alia Moosavian, Bizhan Malaekeh-Nikouei   +4 more
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Anti-nucleolin aptamer-guided anticancer activity of AS1411-Chalcone conjugate in breast cancer

Biochemical and Biophysical Research Communications
The DNA aptamer AS1411 is a 26-nucleotide, guanine-rich oligonucleotide with high specificity for nucleolin-a multifunctional protein overexpressed on the surface of many cancer cells and involved in key processes such as proliferation and apoptosis. By selectively binding nucleolin, AS1411 serves as an ideal targeting ligand for delivering therapeutic
Vijay Murali Ravi Mythili, Vasanth Kanth Thasma Loganathbabu, Kumaran Kasinathan, Anand Krishnan, Srisri Satish Karthik, Kruthika Prakash, Gnanavel Sadasivam, Prakash Gangadaran, ArulJothi Kandasamy Nagarajan   +8 more
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