Results 131 to 140 of about 2,544 (153)

Innovative Applications of Nucleic Acid Aptamers in Colorectal Cancer Diagnosis and Therapy: From Selection Optimization to Clinical Translation. [PDF]

Int J Nanomedicine
Lu JF, Zhang XR, Liu Y, Zhang CL, Wang L, Liu ZQ, Cai J, Yi HW.   +7 more
europepmc   +1 more source

[Ultrasound-synergized targeted nanoparticles suppress proliferation, migration and invasion of hypoxic lung cancer cells <i>in vitro</i>]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Dong J, Guo J, Li D, DU Y.
europepmc   +1 more source

Aptamer-Based Delivery of Genes and Drugs Across the Blood-Brain Barrier. [PDF]

Pharmaceuticals (Basel)
Yang L, Yin Y, Liu X, Guo B.
europepmc   +1 more source

Aptamer-based applications in delivering cancer gene therapies and beyond: state of the art and the missing links to clinical translation. [PDF]

Adv Drug Deliv Rev
Coppola G, Cennamo F, Ciccone G, Ibba ML, Ruscio AD, Vito AD, Esposito CL, Catuogno S.   +7 more
europepmc   +1 more source

Aptamers targeting immune checkpoints for tumor immunotherapy: a comprehensive review. [PDF]

Front Oncol
Gedla MK, Kotla RSP, Kumar R, Kamesh V, S J, Kamalakannan D, Ramasamy J.   +6 more
europepmc   +1 more source

The G-quadruplex-forming aptamer AS1411 potently inhibits HIV-1 attachment to the host cell [PDF]

International Journal of Antimicrobial Agents, 2016
AS1411 is a G-rich aptamer that forms a stable G-quadruplex structure and displays antineoplastic properties both in vitro and in vivo. This oligonucleotide has undergone phase 2 clinical trials. The major molecular target of AS1411 is nucleolin (NCL), a
Rosalba Perrone, Elena Butovskaya, Sara Lago   +2 more
exaly   +2 more sources

AS1411 aptamer-targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast tumor-bearing Mice

Nanomedicine, 2018
AIM: Herein, the AS1411 aptamer-targeted ultrasmall gold nanoclusters (GNCs) were assessed at different aspects as a radiosensitizer. MATERIALS & METHODS: AS1411 aptamer-conjugated gold nanoclusters (Apt-GNCs) efficacy was evaluated at cancer cells ...
Fatemeh Ghahremani, Amirhosein Kefayat, Daryoush Shahbazi-Gahrouei   +2 more
exaly   +2 more sources

Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation

Molecular Oncology, 2015
AS1411 is a G‐rich quadruplex‐forming oligodeoxynucleotide that binds specifically to nucleolin, a protein found on the surface and in the cytoplasm of most malignant cells but absent from the surface/cytoplasm of most normal cells.
Matthew Forsthoefel
exaly   +2 more sources

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Interaction study of Dox-incorporated AS1411 aptamer and nucleolin by molecular dynamics simulation

Molecular Simulation, 2023
Pichayanoot Rotkrua, Boonchoy Soontornworajit, Yuthana Tantirungrotechai   +2 more
exaly