Results 121 to 130 of about 2,325 (152)
Some of the next articles are maybe not open access.
Therapeutic applications of AS1411 aptamer, an update review
International Journal of Biological Macromolecules, 2020Nucleolin or C23, is one of the most abundant non-ribosomal phosphoproteins of nucleolus. However, in several cancers, nucleolin is highly expressed both intracellularly and on the cell surface. So, it is considered as a potential target for the diagnosis and cancer therapy.
Mohammad Ramezani +2 more
exaly +3 more sources
Aptamer imaging with Cu-64 labeled AS1411: Preliminary assessment in lung cancer
Nuclear Medicine and Biology, 2014AS1411 is a 26-base guanine-rich oligonucleotide aptamer shown binding to surface nucleolin, a protein over-expressed in multiple cancer cells, thus AS1411 labeled with a PET isotope can be explored as a potential diagnostic imaging agent. Our objective was to perform preliminary biological characterization of (64)Cu-labeled AS1411 in vitro and in vivo.
Chin K Ng, John Trent, Tariq Malik
exaly +3 more sources
AS1411 aptamer based nanomaterials: A novel approach for breast cancer therapy
International Journal of Biological MacromoleculesBreast cancer remains a leading cause of cancer-related mortality in women, accounting for 23.8 % of all female cancer cases. Existing therapies often lack tumor specificity, leading to severe off-target toxicity, dose-limiting side effects, and poor patient compliance. These limitations underscore the urgent need for innovative strategies that enhance
Wahab Shadma +2 more
exaly +3 more sources
Characterizing Oligonucleotide Uptake in Cultured Cells: A Case Study Using AS1411 Aptamer
Methods in Molecular Biology, 2019Oligonucleotides can be designed or evolved to bind to specific DNA, RNA, protein, or small molecule targets and thereby alter the biological function of the target. The therapeutic potential of oligonucleotides targeted to intracellular molecules will depend largely on their ability to be taken up by the cells of interest, as well as their subsequent ...
Elsa Reyes-Reyes +2 more
exaly +3 more sources
Corneal neovascularization is inhibited with nucleolin-binding aptamer, AS1411
Experimental Eye Research, 2020Corneal neovascularization (CNV) is a common sight-threatening pathology that can be induced by a variety of inflammatory and angiogenic stimuli. Current CNV treatments include anti-inflammatory drugs and antibody-based inhibitors of vascular endothelial growth factor (VEGF).
Oscar, Vivanco-Rojas +8 more
openaire +2 more sources
Aptamer AS1411 utilized for super-resolution imaging of nucleolin
Talanta, 2020Nucleolin (NCL) is a multifunctional protein that mainly localizes in the nucleolus and also distributes in the nucleoplasm, cytoplasm and cell membrane. Most studies focus on its biofunctions in cell activities and diseases, however, its detailed distribution and organization pattern in situ remains obscure.
Yingying, Jing +5 more
openaire +2 more sources
International Journal of Biological Macromolecules, 2018
AS1411 is a nucleolin-binding aptamer which attracted great interest as active targeting ligand for the selective delivery of therapeutic agents to tumour cells. In this work we selected three AS1411 derivatives 5'-conjugated with lipophilic tails and studied their properties in view of their application in liposomial formulations and/or lipid coated ...
Riccardi Claudia +6 more
openaire +5 more sources
AS1411 is a nucleolin-binding aptamer which attracted great interest as active targeting ligand for the selective delivery of therapeutic agents to tumour cells. In this work we selected three AS1411 derivatives 5'-conjugated with lipophilic tails and studied their properties in view of their application in liposomial formulations and/or lipid coated ...
Riccardi Claudia +6 more
openaire +5 more sources
AS1411 aptamer for targetable photosensitizer delivery
2009 International Conference on Biomedical and Pharmaceutical Engineering, 2009A specialized G-quadruplex DNA aptamer with nucleolin targeting ability, AS1411, has been studied for cancer therapy. In this study, we report a novel delivery strategy for chemo-photodynamic combined treatment using AS1411 aptamer conjugated with tetra-(N-methyl-4-pyridyl)-porphine by intercalation and outside binding.
M. J. Shieh, Y. A. Shieh, P. S. Lai
openaire +1 more source
Physical Chemistry Chemical Physics, 2022
The interfacial behaviors of conjugated AS1411 molecules at lipid bilayer interfaces were investigated by SFG-VS. The AS1411 molecules at the DMTAP bilayer show a higher binding affinity but a slower binding kinetics compared to the DMDAP bilayer.
Penghua Li +10 more
openaire +2 more sources
The interfacial behaviors of conjugated AS1411 molecules at lipid bilayer interfaces were investigated by SFG-VS. The AS1411 molecules at the DMTAP bilayer show a higher binding affinity but a slower binding kinetics compared to the DMDAP bilayer.
Penghua Li +10 more
openaire +2 more sources
STUDY OF CATIONIC PORPHYRIN COMPLEXES WITH APTAMER AS1411 BY EPR AND OPTICAL SPECTROSCOPY
X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023: Cб. тез., 2023Porphyrins are photosensitizers (PS) for photodynamic therapy (PDT). However, the most effective PS have poor water solubility, which limits their application in PDT. The solution to this problem is the use of targeted drug delivery, such as the oligonucleotide AS1411.
T.A. Khlynova +2 more
openaire +1 more source