Results 71 to 80 of about 142,838 (307)

Exploring Neuroprotection against Radiation-Induced Brain Injury: A Review of Key Compounds

NeuroSci
Brain radiation is a crucial tool in neuro-oncology for enhancing local tumor control, but it can lead to mild-to-profound and progressive impairments in cognitive function.
Lucas González-Johnson, Ariel Fariña, Gonzalo Farías, Gustavo Zomosa, Víctor Pinilla-González, Catalina Rojas-Solé   +5 more
doaj   +1 more source

Reciprocal Interactions between Cadmium-Induced Cell Wall Responses and Oxidative Stress in Plants

Frontiers in Plant Science, 2017
Cadmium (Cd) pollution renders many soils across the world unsuited or unsafe for food- or feed-orientated agriculture. The main mechanism of Cd phytotoxicity is the induction of oxidative stress, amongst others through the depletion of glutathione ...
Christophe Loix, Michiel Huybrechts, Jaco Vangronsveld, Marijke Gielen, Els Keunen, Ann Cuypers   +5 more
doaj   +1 more source

Mechanisms of Copper Tolerance, Accumulation, and Detoxification in the Marine Macroalga Ulva compressa (Chlorophyta): 20 Years of Research

Plants, 2020
Copper induces an oxidative stress condition in the marine alga Ulva compressa that is due to the production of superoxide anions and hydrogen peroxide, mainly in organelles.
Alejandra Moenne, Melissa Gómez, Daniel Laporte, Daniela Espinoza, Claudio A. Sáez, Alberto González   +5 more
doaj   +1 more source

Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes. [PDF]

, 2018
Oxidative stress is a critical feature of several common neurologic disorders. The brain is well adapted to neutralize oxidative injury by maintaining a high steady-state concentration of small-molecule intracellular antioxidants including glutathione in
Carroll, Valerie N, Flavell, Robert R, Keshari, Kayvan R, Kurhanewicz, John, Mutch, Christopher A, Qin, Hecong, Sriram, Renuka, Villanueva-Meyer, Javier E, von Morze, Cornelius, Wang, Zhen Jane, Wilson, David M   +10 more
core   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Mechanistic studies on DNA damage by minor groove binding copper–phenanthroline conjugates [PDF]

, 2005
Copper–phenanthroline complexes oxidatively damage and cleave nucleic acids. Copper bis-phenanthroline and copper complexes of mono- and bis-phenanthroline conjugates are used as research tools for studying nucleic acid structure and binding interactions.
Bales, Brian C., Greenberg, Marc M., Kodama, Tetsuya, Meunier, Bernard, Pitié, Marguerite, Weledji, Yvonne N.   +5 more
core   +2 more sources

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Human Heme Oxygenase Oxidation of 5- and 15-Phenylhemes [PDF]

, 2004
Human heme oxygenase-1 (hHO-1) catalyzes the O2- dependent oxidation of heme to biliverdin, CO, and free iron. Previous work indicated that electrophilic addition of the terminal oxygen of the ferric hydroperoxo complex to the -meso-carbon gives 5 ...
Alvarez, Diego Ezequiel, Buldain, Graciela Yolanda, Huang, Liusheng, Lad, Latesh, Niemevz, Fernando, Ortiz de Montellano, Paul R., Poulos, Thomas L., Wang, Jingling   +7 more
core   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Oxidative Stress Associated with Chilling Injury in Immature Fruit: Postharvest Technological and Biotechnological Solutions [PDF]

, 2017
Immature, vegetable-like fruits are produced by crops of great economic importance, including cucumbers, zucchini, eggplants and bell peppers, among others. Because of their high respiration rates, associated with high rates of dehydration and metabolism,
Carvajal Moreno, Fátima, Garrido Garrido, María Dolores, Jamilena Quesada, Manuel, Manzano Medina, Susana, Palma, Francisco, Valenzuela Manjón-Cabeza, Juan Luis   +5 more
core   +1 more source