Results 51 to 60 of about 182,632 (352)

Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202 [PDF]

, 2018
CYP17A1 is a key steroidogenic enzyme known to conduct several distinct chemical transformations on multiple substrates. In its hydroxylase activity, this enzyme adds a hydroxyl group at the 17α position of both pregnenolone and progesterone at ...
Bangcharoenpaurpong O., James R. Kincaid, Mak P. J., Michael C. Gregory, Nakajin S., Piotr J. Mak, Shen A. L., Stephen G. Sligar, Yogan Khatri   +8 more
core   +2 more sources

N-(Phenylsulfonyl)-L-asparagine [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
En el compuesto del título, C(10)H(12)N(2)O(5)S, uno de los átomos de sulfonilo O está unido por hidrógeno al átomo de amido N de una molécula adyacente. También hay una interacción débil de enlaces de hidrógeno entre el otro átomo de sulfonilo O y el átomo de amino N secundario.
Muhammad Nadeem Arshad, H. Mubashar-Ur-Rehman, Islam Ullah Khan, Muhammad Shafiq, Kong Mun Lo   +4 more
openaire   +3 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia

Frontiers in Oncology, 2020
Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly regulated at the transcriptional level, being induced by both the Amino Acid ...
Martina Chiu, Giuseppe Taurino, Massimiliano G. Bianchi, Michael S. Kilberg, Ovidio Bussolati   +4 more
doaj   +1 more source

Transcription analysis of apple fruit development using cDNA microarrays [PDF]

, 2009
The knowledge of the molecular mechanisms underlying fruit quality traits is fundamental to devise efficient marker-assisted selection strategies and to improve apple breeding.
Costa, F., Gianfranceschi, L., Molthoff, J.W., Schouten, H.J., Soglio, V., Weemen-Hendriks, M.   +5 more
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Antidepressant Effect of Shaded White Leaf Tea Containing High Levels of Caffeine and Amino Acids

Molecules, 2020
The young leaves of green tea become lighter in color than usual when protected from sunlight by a shading net for about two weeks while growing. These leaves are called “shaded white leaf tea” or SWLT.
Keiko Unno, Daisuke Furushima, Yuzuki Nomura, Hiroshi Yamada, Kazuaki Iguchi, Kyoko Taguchi, Toshikazu Suzuki, Makoto Ozeki, Yoriyuki Nakamura   +8 more
doaj   +1 more source

Asparagine Metabolic Pathways in Arabidopsis [PDF]

Plant and Cell Physiology, 2015
Inorganic nitrogen in the form of ammonium is assimilated into asparagine via multiple steps involving glutamine synthetase (GS), glutamate synthase (GOGAT), aspartate aminotransferase (AspAT) and asparagine synthetase (AS) in Arabidopsis. The asparagine amide group is liberated by the reaction catalyzed by asparaginase (ASPG) and also the amino group ...
Gaufichon, Laure, Rothstein, Steven J, Suzuki, Akira   +2 more
openaire   +4 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

An asparagine metabolism-based classification reveals the metabolic and immune heterogeneity of hepatocellular carcinoma [PDF]

, 2022
Jianguo Bai, Ruifeng Tang, Keyu Zhou, Jialei Chang, Hongyue Wang, Qixin Zhang, Jiahui Shi, Chao Sun   +7 more
openalex   +1 more source