Results 101 to 110 of about 1,135 (159)

Astragaloside IV protects against the pathological cardiac hypertrophy in mice

Biomedicine & Pharmacotherapy, 2018
Although pathologic hypertrophic hearts currently maintain output, sustained cardiac hypertrophy could predispose a patient to arrhythmia and sudden death, and also cause heart failure. Thus, finding effective treatment and exploring the underlying molecular mechanisms of cardiac hypertrophy is urgently necessary.
Zhen-Hu, Liu, Hong-Bo, Liu, Jun, Wang
openaire   +2 more sources

The effect of astragaloside IV on a model of isoproterenol-induced hypertrophic injury in H9c2 cells

Acta Pharmaceutica
The objective of this study was to explore the protective effect of astragaloside IV on a model of isoproterenol-induced (ISO) hyper-trophic injury in rat cardiomyocytes H9c2 (cell line derived from embryonic BD1X rat heart tissue).
Long Yang, Xiao Yuan, Chen Chun, Peng Chao, Zhang Yuxi   +4 more
doaj   +1 more source

Astragaloside IV attenuated EAE progression.

, 2013
A, ASI treatment given at 20/kg/day i.p. from one day before MOG35–55 immunization and continued for 14 days significantly reduced mean clinical score of EAE mice.
Yan Gao (93649), Hongshuai Liu (466800), Yixin He (466799), Hongwei Wang (151141), Xiaojun Wu (466801), Zhengtao Wang (466802), Min Du (292028)   +6 more
core   +1 more source

AS-IV Attenuates Oxidative Stress-Induced Apoptosis in Zebrafish via Modulation of the AKT/NRF2/HO-1/Caspase-3 Signaling Axis

Molecules
As the primary active component of Astragalus membranaceus, Astragaloside IV (AS-IV) is widely recognized in pharmacological research for its multifaceted therapeutic potential, particularly its antioxidative, immunostimulatory, and cardioprotective ...
Jili Dai, Zhizhou E, Yannan Bi, Zetao Yin, Yanfang Wang, Xingyu Wang, Xiaoe Jia, Bo Zou   +7 more
doaj   +1 more source

Astragaloside IV Attenuates Angiotensin II-Induced Inflammatory Responses in Endothelial Cells: Involvement of Mitochondria

Shiyu Zhang, Shijie Li, Lin Cui, Shiyang Xie, Youping Wang Division of Cardiology and Central Laboratory, First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of ChinaCorrespondence: Youping ...
Li S, Cui L, Zhang S, Wang Y, Xie S
core  

MOESM1 of Astragaloside IV attenuates gestational diabetes mellitus via targeting NLRP3 inflammasome in genetic mice

, 2019
Additional file 1: Table S1.
Peipei Zhang (1360440), Ruixue Zhang (250760), Fengzhen Yang (7436483), Xuelei Zhang (2703268), Jianyong Zhao (7436480), Baoheng Xing (7436477), Dandan Shi (4333591)   +6 more
core   +1 more source

Therapeutic potential and mechanistic insights of astragaloside IV in the treatment of arrhythmia: a comprehensive review

Frontiers in Pharmacology
Arrhythmia, a common cardiovascular disorder, results from disturbances in cardiac impulse generation and conduction, leading to decreased cardiac output and myocardial oxygenation, with potentially life-threatening consequences.
Meilian Chen, Binlan Fu, Hao Zhou, Qiaomin Wu   +3 more
doaj   +1 more source

Astragaloside IV Alleviates Systemic Lupus Erythematosus by Modulating ITGB1/PTK2/p38 Pathway: Integrated Network Pharmacology and Experimental Validation

Zhongfu Tang, Lili Cheng, Ming Li, Chuanbing Huang Department of Rheumatology, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, People’s Republic of ChinaCorrespondence: Chuanbing Huang, Department of Rheumatology,
Tang Z, Huang C, Cheng L, Li M
core  

Effect of astragaloside IV on different gastric parameters of WRS-induced rats.

, 2016
Effect of astragaloside IV on different gastric parameters of WRS-induced rats.
Minzhou Zhang (2161828), Shuai Mao (1627021), Hailong Liang (2161834), Winny Li (2161831), Jian Li (41607), Guang Yang (154978), Jian Zhang (1682)   +6 more
core   +1 more source

Astragaloside IV-PESV inhibits prostate cancer tumor growth by restoring gut microbiota and microbial metabolic homeostasis via the AGE-RAGE pathway

BMC Cancer
Background Prostate cancer (PCa) is becoming the most common malignancy in men worldwide. We investigated the effect of astragaloside IV combined with PESV on the gut microbiota and metabolite of PCa mice and the process of treating PCa.
Xujun You, Junfeng Qiu, Qixin Li, Qing Zhang, Wen Sheng, Yiguo Cao, Wei Fu   +6 more
doaj   +1 more source