Results 31 to 40 of about 283,599 (345)

Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels

Nature Communications, 2023
Astrocytes contribute to brain inflammation in neurological disorders but the molecular mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory endpoints are complex and poorly understood.
Michaela M. Novakovic, Kirill S. Korshunov, Rogan A. Grant, Megan E. Martin, Hiam A. Valencia, G. R. Scott Budinger, Jelena Radulovic, Murali Prakriya   +7 more
doaj   +1 more source

Astrocyte polarization in glaucoma: a new opportunity

Neural Regeneration Research, 2022
Astrocyte polarization is a new concept which is similar to microglia polarization and in which astrocytes are classified as A1 (neurotoxic) and A2 (neuroprotective).
Yi-Xin Liu, Hao Sun, Wen-Yi Guo
doaj   +1 more source

The role of reactive astrocitose in the chronological evolution of traumatic brain injury [PDF]

, 2018
Introduction and objectives. This study aims to investigate whether the cerebral modifications of posttraumatic reactive astrocitose can be considered an objective criterion for determining the age of traumatic cranio-cerebral lesions.
Belis, Vladimir, Calota, Relu G., Costescu, Mihnea, Duncea-Borca, Roxana M., Kutasi, Reka, Moldovan, Cosmin A.   +5 more
core   +4 more sources

Astrocyte development—More questions than answers

Frontiers in Cell and Developmental Biology, 2023
The past 15–20 years has seen a remarkable shift in our understanding of astrocyte contributions to central nervous system (CNS) function. Astrocytes have emerged from the shadows of neuroscience and are now recognized as key elements in a broad array of
Kathryn M. Markey, Jillian C. Saunders, Jana Smuts, Catherine R. von Reyn, Catherine R. von Reyn, A. Denise R. Garcia, A. Denise R. Garcia   +6 more
doaj   +1 more source

Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. [PDF]

, 2018
Reactive astrocytes influence post-injury recovery, repair, and pathogenesis of the mammalian CNS. Much of the regulation of astrocyte reactivity, however, remains to be understood.
Carolino, Krislyn I, Chen, Meifan, Elzière, Lucie, Geoffroy, Cédric G, Goldberg, Mark P, Jin, Yishi, Khai, Vung S, Kong, Xiangmei, Li, Yunbo, Meves, Jessica M, Narang, Aarti, Nguyen, Mallorie T, Steinke, Christopher L, Zheng, Binhai   +13 more
core   +2 more sources

Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity

Frontiers in Physiology, 2019
The functional role of astrocyte calcium signaling in brain information processing was intensely debated in recent decades. This interest was motivated by high resolution imaging techniques showing highly developed structure of distal astrocyte processes.
Susan Yu. Gordleeva, Anastasia V. Ermolaeva, Innokentiy A. Kastalskiy, Victor B. Kazantsev   +3 more
doaj   +1 more source

Disentangling astroglial physiology with a realistic cell model in silico [PDF]

, 2018
Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and generate Ca2+ signals that release molecular regulators of neural circuitry.
A Araque, A Chvatal, A Grosche, A Panatier, A Verkhratsky, A Volterra, A Wallraff, AM Reeves, B Djukic, BA MacVicar, BS Khakh, C Giaume, C Henneberger, CC Fink, DA Rusakov, DA Rusakov, DA Rusakov, DE Bergles, E Scemes, E Shigetomi, EA Bushong, EA Newman, F Ding, F Oschmann, G Seifert, G Ullah, G Wallach, GG Viola, I Patrushev, J Golowasch, J Grosche, J Schaff, J Sibille, K Hama, K Ogata, K Thurley, K Zheng, K Zheng, KC Chen, KP Lehre, KP Lehre, KY Zheng, LP Savtchenko, LP Savtchenko, M Nedergaard, M Pitta De, M Pitta De, MA Castro Di, MD Haustein, MJ Berridge, ML Hines, ML Hines, MR Witcher, N Bazargani, N Hernjak, N Medvedev, P Kofuji, PX Cao, R Srinivasan, R Ventura, RL Rungta, S Anders, S Sylantyev, T Hofer, T Manninen, TaufiqUrRahman, TW Chen, V Parpura, WN Ross, Z Wang, Z Zhang   +70 more
core   +3 more sources

Normal aging induces A1-like astrocyte reactivity

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance In aging, the brain becomes vulnerable to injury and cognitive function declines, but the mechanisms responsible are unknown. Astrocytes, the most abundant class of glial cells, are vital for the proper function of the central nervous system,
L. Clarke, S. A. Liddelow, C. Chakraborty, Alexandra E. Münch, M. Heiman, B. Barres   +5 more
semanticscholar   +1 more source

Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration

Journal of Neuroinflammation, 2020
Background Neuronal damage in acute CNS injuries and chronic neurodegenerative diseases is invariably accompanied by an astrocyte reaction in both mice and humans.
Sudeshna Das, Zhaozhi Li, Ayush Noori, Bradley T. Hyman, Alberto Serrano-Pozo   +4 more
doaj   +1 more source

Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. [PDF]

, 2018
Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known.
Bu, Jung Hyun, Ellisman, Mark H, Jeong, Seung Won, Ju, Won-Kyu, Kim, Keun-Young, Nam, Hye Seung, Park, Tae Lim, Shim, Myoung Sup, Weinreb, Robert N   +8 more
core   +2 more sources