Results 41 to 50 of about 194,703 (370)
Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity
Frontiers in Physiology, 2019 The functional role of astrocyte calcium signaling in brain information processing was intensely debated in recent decades. This interest was motivated by high resolution imaging techniques showing highly developed structure of distal astrocyte processes.
Susan Yu. Gordleeva +3 more
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Journal of Integrative Neuroscience, 2022 The cellular, molecular and physiological basis of cognition has proved elusive until emerging studies on astrocytes. The appearance of a deliberate aggregating element in cellular neurophysiology was difficult to satisfy computationally with excitatory and inhibitory neuron physiology alone.
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Copper metabolism of astrocytes [PDF]
Frontiers in Aging Neuroscience, 2013 This short review will summarize the current knowledge on the uptake, storage, and export of copper ions by astrocytes and will address the potential roles of astrocytes in copper homeostasis in the normal and diseased brain. Astrocytes in culture efficiently accumulate copper by processes that include both the copper transporter Ctr1 and Ctr1 ...
Ivo F. Scheiber +2 more
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A tale of two stories: astrocyte regulation of synaptic depression and facilitation [PDF]
PLoS Comput. Biol. (2011) 7(12): e1002293, 2011 Short-term presynaptic plasticity designates variations of the amplitude of synaptic information transfer whereby the amount of neurotransmitter released upon presynaptic stimulation changes over seconds as a function of the neuronal firing activity. While a consensus has emerged that changes of the synapse strength are crucial to neuronal computations,
arxiv +1 more source
Functional immune cell–astrocyte interactions
Journal of Experimental Medicine, 2021 Astrocytes are glial cells of the central nervous system (CNS) that are strategically positioned to control CNS immunity in the context of health and disease.
L. Sanmarco +3 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2020 Background Neuronal damage in acute CNS injuries and chronic neurodegenerative diseases is invariably accompanied by an astrocyte reaction in both mice and humans.
Sudeshna Das +4 more
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Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
Nature Communications, 2020 Reactive astrocytes have been implicated in the pathogenesis of neurodegenerative diseases, including a non-cell autonomous effect on motor neuron survival in ALS.
Kevin A. Guttenplan +6 more
semanticscholar +1 more source
Extracellular regulated kinase 1/2 signaling is a critical regulator of interleukin-1β-mediated astrocyte tissue inhibitor of metalloproteinase-1 expression. [PDF]
PLoS ONE, 2013 Astrocytes are essential for proper central nervous system (CNS) function and are intricately involved in neuroinflammation. Despite evidence that immune-activated astrocytes contribute to many CNS pathologies, little is known about the inflammatory ...
Jerel Fields +3 more
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Olig2-Lineage Astrocytes: A Distinct Subtype of Astrocytes That Differs from GFAP Astrocytes [PDF]
Frontiers in Neuroanatomy, 2018 Astrocytes are the most abundant glia cell type in the central nervous system (CNS), and are known to constitute heterogeneous populations that differ in their morphology, gene expression and function. Although glial fibrillary acidic protein (GFAP) is the cardinal cytological marker of CNS astrocytes, GFAP-negative astrocytes can easily be found in ...
Akio Wanaka +10 more
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Novel cell separation method for molecular analysis of neuron-astrocyte cocultures
Frontiers in Cellular Neuroscience, 2014 Over the last decade, the importance of astrocyte-neuron communication in neuronal development and synaptic plasticity has become increasingly clear. Since neuron-astrocyte interactions represent highly dynamic and reciprocal processes, we hypothesized ...
Andrea eGoudriaan +8 more
doaj +1 more source