Results 41 to 50 of about 71,066 (193)

Augmented Cystine–Glutamate Exchange by Pituitary Adenylate Cyclase-activating Polypeptide Signaling via the VPAC1 Receptor [PDF]

, 2014
In the central nervous system, cystine import in exchange for glutamate through system xc- is critical for the production of the antioxidant glutathione by astrocytes, as well as the maintenance of extracellular glutamate. Therefore, regulation of system
Arimura, Ashur-Fabian, Asztely, Baker, Baker, Baker, Bannai, Bannai, Barger, Berman, Brenneman, Brown, Chen, Choi, Costa, Diamond, Dickson, Dugan, Fahrenkrug, Figiel, Fogal, Ghatei, Grant, Grant, Grimaldi, Grimaldi, Groot, Hannibal, Hannibal, Hashimoto, Jackman, Johnson, Joo, Joo, Knackstedt, Kranich, Kupchik, Lewerenz, Liu, Liu, Liu, Liu, Lobner, Macdonald, Magistretti, Martin, Masmoudi-Kouki, Masmoudi-Kouki, Moran, Morio, Murphy, Park, Piani, Pow, Rush, Rush, Sagara, Said, Sato, Schwartz, Seaborn, Shih, Shintani, Sontheimer, Suh, Suzuki, Tatsuno, Tatsuno, Vaudry, Vaudry, Yaka, Ye, Yuhara, Zheng, Zhou   +74 more
core   +2 more sources

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection [PDF]

, 2017
Type I IFNs promote cellular responses to viruses, and IFN receptor (IFNAR) signaling regulates the responses of endothelial cells of the blood-brain barrier (BBB) during neurotropic viral infection.
Ali, An, Archambault, Brian P. Daniels, Brien, Cramer, Daniels, Douglas M. Durrant, Furr, Furr, Getts, Harsha Jujjavarapu, Hart, Helen M. Lazear, James P. White, Jessica L. Williams, Michael Gale, Michael S. Diamond, Morga, Pfefferkorn, Richard R. Green, Robyn S. Klein, Rothhammer, Wang   +23 more
core   +3 more sources

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Foreign body responses in central nervous system mimic natural wound responses and alter biomaterial functions [PDF]

, 2019
Biomaterials hold promise for diverse therapeutic applications in the central nervous system (CNS). Little is known about molecular factors that determine CNS foreign body responses (FBRs) in vivo , or about how such responses influence biomaterial ...
Ao, Yan, Deming, Timothy, Kim, Jae, O’Shea, Timothy, Sofroniew, Michael, Wollenberg, Alexander   +5 more
core   +1 more source

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function. [PDF]

, 2019
Rett syndrome (RTT) is a pervasive developmental disorder caused by mutations in MECP2. Complete loss of MECP2 function in males causes congenital encephalopathy, neurodevelopmental arrest, and early lethality.
Carromeu, Cassiano, Freitas, Beatriz CG, Ghosh, Anirvan, Hu, Xindao, Kim, Jean J, Lavallée-Adam, Mathieu, Miller, Meghan T, Muotri, Alysson R, Savas, Jeffrey N, Yates, John R   +9 more
core   +2 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Voxel-wise comparisons of cellular microstructure and diffusion-MRI in mouse hippocampus using 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND) [PDF]

, 2018
A key challenge in medical imaging is determining a precise correspondence between image properties and tissue microstructure. This comparison is hindered by disparate scales and resolutions between medical imaging and histology.
Ball, G, Edwards, A D, Jones, M, So, P-W, Stolp, H B, Thornton, C, Tournier, J-D   +6 more
core   +6 more sources

Association of CDKN2A/B Homozygous Deletion and Extent of Resection With Survival of Patients With WHO CNS5 Grade 4 Astrocytoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives WHO grade 4 astrocytomas are associated with poor prognosis, and their prognostic factors remain controversial. This study aimed to identify the prognostic factors and develop a management algorithm for these patients. Methods This study retrospectively included 151 CNS5 adult grade 4 astrocytomas from two medical centers.
Jiawei Cai, Guanglin Zhu, Qiu He, Chen Luo, Lingyun Zhuo, Xingfu Wang, Yiming Chen, Xiaoyong Chen, Wendong You, Jiaheng Xu, Yuanxiang Lin, Dezhi Kang, Shuai Wu, Zanyi Wu   +13 more
wiley   +1 more source