Results 41 to 50 of about 269,912 (335)

Astrocyte-immune cell interactions in physiology and pathology.

Immunity, 2021
Astrocytes play both physiological and pathological roles in maintaining central nervous system (CNS) function. Here, we review the varied functions of astrocytes and how these might change in subsets of reactive astrocytes.
R. T. Han, Rachel D. Kim, A. Molofsky, SA Liddelow   +3 more
semanticscholar   +1 more source

Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels

Nature Communications, 2023
Astrocytes contribute to brain inflammation in neurological disorders but the molecular mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory endpoints are complex and poorly understood.
Michaela M. Novakovic, Kirill S. Korshunov, Rogan A. Grant, Megan E. Martin, Hiam A. Valencia, G. R. Scott Budinger, Jelena Radulovic, Murali Prakriya   +7 more
doaj   +1 more source

Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons [PDF]

, 2016
Perinatal Asphyxia (PA) represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness.
Barreto, George E., Capani, Francisco, Castilla Lozano, Maria del Rocio, Holubiec, Mariana Ines, Logica Tornatore, Tamara Maite Ayelén, Riviere, Stephanie   +5 more
core   +1 more source

Normal aging induces A1-like astrocyte reactivity

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance In aging, the brain becomes vulnerable to injury and cognitive function declines, but the mechanisms responsible are unknown. Astrocytes, the most abundant class of glial cells, are vital for the proper function of the central nervous system,
L. Clarke, S. A. Liddelow, C. Chakraborty, Alexandra E. Münch, M. Heiman, B. Barres   +5 more
semanticscholar   +1 more source

Ultrastructural view of astrocyte arborization, astrocyte-astrocyte and astrocyte-synapse contacts, intracellular vesicle-like structures, and mitochondrial network.

Progress in neurobiology, 2022
The complexity of astrocyte morphology and syncytial coupling through gap junctions are crucial for astrocyte function in the brain. However, the ultrastructural details of astrocyte arborization and interactions between neighboring astrocytes remain ...
Sydney Aten, Conrad M. Kiyoshi, Emily Arzola, J. Patterson, Anne T. Taylor, Yixing Du, Ally M. Guiher, Merna Philip, Elizabeth Gerviacio Camacho, Devin Mediratta, Kelsey A. Collins, K. Boni, Silvana A. Garcia, R. Kumar, Aiden N. Drake, Ahlam Hegazi, Lindsey Trank, Emily K. Benson, G. Kidd, D. Terman, Min Zhou   +20 more
semanticscholar   +1 more source

Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity

Frontiers in Physiology, 2019
The functional role of astrocyte calcium signaling in brain information processing was intensely debated in recent decades. This interest was motivated by high resolution imaging techniques showing highly developed structure of distal astrocyte processes.
Susan Yu. Gordleeva, Anastasia V. Ermolaeva, Innokentiy A. Kastalskiy, Victor B. Kazantsev   +3 more
doaj   +1 more source

Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration

Journal of Neuroinflammation, 2020
Background Neuronal damage in acute CNS injuries and chronic neurodegenerative diseases is invariably accompanied by an astrocyte reaction in both mice and humans.
Sudeshna Das, Zhaozhi Li, Ayush Noori, Bradley T. Hyman, Alberto Serrano-Pozo   +4 more
doaj   +1 more source

Novel cell separation method for molecular analysis of neuron-astrocyte cocultures

Frontiers in Cellular Neuroscience, 2014
Over the last decade, the importance of astrocyte-neuron communication in neuronal development and synaptic plasticity has become increasingly clear. Since neuron-astrocyte interactions represent highly dynamic and reciprocal processes, we hypothesized ...
Andrea eGoudriaan, Nutabi eCamargo, Karen eCarney, Karen eCarney, Karen eCarney, Stéphane H.R. Oliet, Stéphane H.R. Oliet, August B. Smit, Mark H.G. Verheijen   +8 more
doaj   +1 more source

An efficient platform for astrocyte differentiation from human induced pluripotent stem cells [PDF]

, 2017
Summary: Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from ...
Abdelaal, Rawan, Bowles, Kathryn R, Brennand, Kristen J, Goate, Alison M, Hartley, Brigham J, Karch, Celeste M, Lacin, Emre, Machlovi, Saima I, Phatnani, Hemali, Pimenova, Anna A, Slesinger, Paul A, TCW, Julia, Wang, Minghui, Zhang, Bin   +13 more
core   +3 more sources

FGFR3-TACC3 fusion as a potential primary resistance mechanism to EGFR-TKI in lung adenocarcinoma harboring co-driven mutations: a case report

Frontiers in Oncology
Oncogenic driver mutations were once considered mutually exclusive in non-small cell lung cancer (NSCLC), and the optimal management for these patients with co-mutations of driver genes remains controversial.
Xiuwen Wang, Liwen Qiu, Jizhen Liang, Fei Liu, Xiaoxue Ma, Pan Yang   +5 more
doaj   +1 more source