Results 141 to 150 of about 31,071 (248)

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma

Advanced Science, EarlyView.
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong, Chen Lin, Wenjie Long, Ian Kim, Mengwen Xiong, Zuer Wu, Siyuan Rao, Qianbin Wang   +7 more
wiley   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis

Advanced Science, EarlyView.
During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang   +10 more
wiley   +1 more source

Chrysanthemum Morifolium–Derived Nanovesicles Reduce Lactate‐Associated Histone Lactylation and Modulate Microglia‐Mediated Neuroinflammation in Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
When used to treat sepsis‐associated encephalopathy, Chrysanthemum morifolium–derived nanovesicles can inhibit the H3K18la/NF‐κB axis to regulate microglia‐mediated neuroinflammation. ABSTRACT Sepsis‐associated encephalopathy (SAE)—a complication of the central nervous system in patients with sepsis—markedly diminishes cognitive functions and is linked
Kaiqiang Li, Xuling Luo, Xiaoting Zhang, Chengwen He, Wei Xu, Aibo Xu, Shushan Hua, Liping Wang, Liang Ma, Ke Hao, Youmin Ying, Zhen Wang   +11 more
wiley   +1 more source

A Biomimetic PLK1 Nanodelivery System Promotes Migrasome‐Mediated Mitocytosis to Restore Efferocytosis and Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
MM‐NPs@PLK1 are formed by encapsulating PLK1 plasmids within CBP5 and coating the nanocomplexes with macrophage membranes. After macrophage‐associated uptake, the NPs@PLK1 enter the cytoplasm and release the PLK1‐encoding plasmid in response to elevated intracellular ROS levels.
Zhenxin Hu, Haoli Wang, Jing Huang, Junhua Zhou, Jialong Hou, Hanwei Miao, Huixin Tan, Yining Wang, Hao Hu, Na Li, Pengcheng Qiu, Hongyu Zhang, Da He, Qingqing Wang   +13 more
wiley   +1 more source

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Modeling reaction-diffusion processes in simplified to complex astroglial branchlet geometries using different simulation tools. [PDF]

PLoS Comput Biol
Keto L, Seppälä S, Ndubuaku D, Mäki A, Mäki-Marttunen T, Linne ML, Manninen T.   +6 more
europepmc   +1 more source