Results 51 to 60 of about 1,396,802 (284)

KCa3.1 deficiency attenuates neuroinflammation by regulating an astrocyte phenotype switch involving the PI3K/AKT/GSK3β pathway

Neurobiology of Disease, 2019
Neuroinflammation may induce a phenotype switch to reactive astrogliosis in neurodegenerative disorders. The calcium-activated potassium channel (KCa3.1) is active in the phenotypic switch that occurs during astrogliosis in Alzheimer's disease and ...
Tianjiao Wei, Yanxia Wang, Weirong Xu, Yan Liu, Hongzhuan Chen, Zhihua Yu   +5 more
doaj   +1 more source

Postnatal development of dendritic calcium signaling in rat hippocampal pyramidal cells [PDF]

, 2013
In CA1 pyramidal neurons, dendritic calcium transients in stratum radiatum were evoked in acute slices via backpropagating action potentials using patch clamp recordings.
Pohle, Jörg
core   +1 more source

Astrocytic Ca2+ Signaling in Epilepsy

Frontiers in Cellular Neuroscience, 2021
Epilepsy is one of the most common neurological disorders – estimated to affect at least 65 million worldwide. Most of the epilepsy research has so far focused on how to dampen neuronal discharges and to explain how changes in intrinsic neuronal activity
Kjell Heuser, Rune Enger
doaj   +1 more source

A Non-Canonical Role for IRE1α Links ER and Mitochondria as Key Regulators of Astrocyte Dysfunction: Implications in Methamphetamine use and HIV-Associated Neurocognitive Disorders

Frontiers in Neuroscience, 2022
Astrocytes are one of the most numerous glial cells in the central nervous system (CNS) and provide essential support to neurons to ensure CNS health and function.
Jessica Proulx, Satomi Stacy, In-Woo Park, Kathleen Borgmann   +3 more
doaj   +1 more source

Cellular and nuclear morphology…and calcium signaling: revealing the interplay between structure and function [PDF]

, 2012
Poster presentation: Calcium plays a pivotal role in relaying electrical signals of the cell to subcellular compartments, such as the nucleus. Since this one ion type is used by the cell for many processes a neuron needs to establish finely tuned calcium
Queisser, Sean Gillian, Hagenston, Anna, Breit, Markus, Bengtson, Peter von der, Bading, Hilmar   +4 more
core   +1 more source

Functional implications of calcium permeability of the channel formed by pannexin 1. [PDF]

, 2006
Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 results in the formation of Ca(2+)-permeable gap ...
Ivanov, Dmitry, V, Panchin, YV, Vanden Abeele, F, Fabien Vanden Abeele, Panchin, Yuri V, Gordienko, D, Yuri V. Panchin, Baranova, AV, Skryma, R, Baranova, Ancha, V, Skryma, Roman, Gordienko, Dmitri, Gabriel Bidaux, Beck, Benjamin, Ivanov, DV, Prevarskaya, N, Ancha V. Baranova, Baranova, Ancha V, Natalia Prevarskaya, Benjamin Beck, Ivanov, Dmitry V, Panchin, Yuri, Ivanov, Dimitri, Prevarskaya, Natalia, Vanden Abeele, Fabien, Bidaux, G, Bidaux, Gabriel, Dmitry V. Ivanov, Beck, B, Panchin, Yuri, V, Roman Skryma, Dmitri Gordienko   +31 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Contribution of astrocytic calcium signaling to auditory hypersensitivity in a mouse model of fragile X syndrome

Neurobiology of Disease
Hypersensitivity to sensory stimuli is a common co-morbidity of Fragile X syndrome (FXS), the leading monogenic form of intellectual disability and autism spectrum disorder (ASD). Neuronal impairments associated with auditory and tactile hypersensitivity
Lara Bergdolt, Alexandria Anding, Ola Alshaqi, Zahra Arbabi, Michael Douchey, Ember Eldridge, Katherine Hoffman, Ashley Reid, Kiran Sapkota, Daniel Monaghan, Olga Taraschenko, Ragunathan Padmashri, Anna Dunaevsky   +12 more
doaj   +1 more source

Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity

Frontiers in Computational Neuroscience, 2012
The complexity of the signaling network that underlies astrocyte-synapse interactions may seem discouraging when tackled from a theoretical perspective.
Maurizio eDe Pitta', Vladislav eVolman, Vladislav eVolman, Vladislav eVolman, Hugues eBerry, Vladimir eParpura, Vladimir eParpura, Andrea eVolterra, Eshel eBen-Jacob, Eshel eBen-Jacob, Eshel eBen-Jacob   +10 more
doaj   +1 more source

Information transfer in signaling pathways : a study using coupled simulated and experimental data [PDF]

, 2008
Background: The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown.
Kummer, U. (Ursula), Green, Anne K., Green, A. K., Kummer, U., Pahle, J., Pahle, Jürgen, Dixon, C. Jane, Dixon, C. J.   +7 more
core   +1 more source