Results 31 to 40 of about 1,396,802 (284)
Nature Communications, 2023 Astrocytes contribute to brain inflammation in neurological disorders but the molecular mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory endpoints are complex and poorly understood.
Michaela M. Novakovic +7 more
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Activity-dependent modulation of synapse-regulating genes in astrocytes
eLife, 2021 Astrocytes regulate the formation and function of neuronal synapses via multiple signals; however, what controls regional and temporal expression of these signals during development is unknown.
Isabella Farhy-Tselnicker +9 more
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Gray matter NG2 cells display multiple Ca2+-signaling pathways and highly motile processes [PDF]
, 2011 NG2 cells, the fourth type of glia in the mammalian CNS, receive synaptic input from neurons. The function of this innervation is unknown yet. Postsynaptic changes in intracellular Ca2+-concentration ([Ca2+]i) might be a possible consequence. We employed
Steinhäuser, Christian +21 more
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Morphological and physiological interactions of NG2-glia with astrocytes and neurons [PDF]
, 2007 Models of central nervous system (CNS) function have historically been based on neurons and their synaptic contacts - the neuronal doctrine. This doctrine envisages glia as passive supportive cells.
Hamilton, N. +12 more
core +1 more source
SSRN Electronic Journal, 2023 The Astrocytic Calcium Signaling Toolkit (astroCaST) is a novel solution to a longstanding challenge in neuroscience research: the specialized analysis of astrocytic calcium events within fluorescence time-series imaging. Distinct from existing neuron-centric tools, astroCaST is adept at detecting and clustering astrocytic calcium events based on their
Jan Philipp Reising +8 more
openaire +3 more sources
Activity changes in neuron-astrocyte networks in culture under the effect of norepinephrine. [PDF]
PLoS ONE, 2018 The concerted activity of neuron-glia networks is responsible for the fascinating dynamics of brain functions. Although these networks have been extensively investigated using a variety of experimental (in vivo and in vitro) and theoretical models, the ...
Yasmin Bar El +3 more
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Determinants of functional coupling between astrocytes and respiratory neurons in the pre-Bötzinger complex. [PDF]
PLoS ONE, 2011 Respiratory neuronal network activity is thought to require efficient functioning of astrocytes. Here, we analyzed neuron-astrocyte communication in the pre-Bötzinger Complex (preBötC) of rhythmic slice preparations from neonatal mice. In astrocytes that
Christian Schnell +2 more
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Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]
, 2014 Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana +17 more
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Calcium Signals in Astrocyte Microdomains, a Decade of Great Advances [PDF]
Frontiers in Cellular Neuroscience, 2021 The glial cells astrocytes have long been recognized as important neuron-supporting elements in brain development, homeostasis, and metabolism. After the discovery that the reciprocal communication between astrocytes and neurons is a fundamental mechanism in the modulation of neuronal synaptic communication, over the last two decades astrocytes became ...
Annamaria Lia +12 more
openaire +5 more sources
Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity
Frontiers in Physiology, 2019 The functional role of astrocyte calcium signaling in brain information processing was intensely debated in recent decades. This interest was motivated by high resolution imaging techniques showing highly developed structure of distal astrocyte processes.
Susan Yu. Gordleeva +3 more
doaj +1 more source