Results 21 to 30 of about 1,396,802 (284)

Heat stress-activated P2X7 receptor induces astrocyte activation and regulates glioma tumor microenvironment via calcium signaling pathway

Neuroimmunomodulation
Background and aims: The effects of adjuvant hyperthermia on glioblastoma-associated astrocytes remain poorly characterized. This study aimed to investigate the role of the purinergic P2X7 receptor, an ATP-gated ion channel, in mediating heat ...
Qiang Wang, XiangRui Chen, JiuJiang Zhang, YanGuo Zhang, HeMin Yang   +4 more
doaj   +2 more sources

Constellations of Thought: Astrocytic Contributions to Cognition Across Rodent Models of Brain Dysfunction [PDF]

Biomolecules
Astrocytes are now recognized as active and essential participants in neural circuit function, extending far beyond their traditional roles as passive support cells.
Konstantin Andrianov, Inna Gaisler-Salomon   +1 more
doaj   +2 more sources

Parallel astrocyte calcium signaling modulates olfactory bulb responses. [PDF]

J Neurosci Res, 2020
Ung K, Tepe B, Pekarek B, Arenkiel BR, Deneen B.   +4 more
europepmc   +2 more sources

Functional Ca2+-permeable AMPA receptors in hippocampal astrocytes mediate calcium signaling in vitro [PDF]

Scientific Reports
Glutamate is the main excitatory neurotransmitter in the brain, acting through ionotropic receptors such as AMPA receptors (AMPARs). While their neuronal role is well established, AMPAR function in astrocytes remains poorly understood, especially in the ...
Javier Picañol, Aida Castellanos, Esther Gratacòs-Batlle, Roberto García, Silvia Ginés, Xavier Gasull, Lydia Jiménez-Díaz, Juan D. Navarro-López, David Soto   +8 more
doaj   +2 more sources

Calcium imaging and BAPTA loading of amygdala astrocytes in mouse brain slices

STAR Protocols, 2022
Summary: Astrocytes are glial cells that exhibit calcium signaling-mediated activity. Here, we present a protocol to monitor and manipulate astrocyte calcium activity from mouse amygdala slices.
Angel Baudon, Etienne Clauss-Creusot, Pascal Darbon, Ryan Patwell, Valery Grinevich, Alexandre Charlet   +5 more
doaj   +1 more source

Astrocyte calcium signaling: from observations to functions and the challenges therein. [PDF]

Cold Spring Harb Perspect Biol, 2015
Khakh BS, McCarthy KD.
europepmc   +2 more sources

Astrocyte calcium signaling and epilepsy [PDF]

Glia, 2012
AbstractStudies performed over the last decade, in both animal models and human epilepsy, support the view that a defective K+ buffering due to an altered expression of K+ and aquaporin channels in astrocytes represents a possible causative factor of the pathological neuronal hyperexcitability in the epileptic brain.
Carmignoto, Giorgio, Haydon, Philip G.
openaire   +2 more sources

Correction: Advances in astrocytic calcium signaling research

Frontiers in Cellular Neuroscience
Yuzhu Chen, Yejun Ye, Joyce Jia, Binhao Long, Tingting Dou, Xingke Yan   +5 more
doaj   +5 more sources

Potassium dependent regulation of astrocyte water permeability is mediated by cAMP signaling. [PDF]

PLoS ONE, 2012
Astrocytes express potassium and water channels to support dynamic regulation of potassium homeostasis. Potassium kinetics can be modulated by aquaporin-4 (AQP4), the essential water channel for astrocyte water permeability regulation.
Yutong Song, Eli Gunnarson
doaj   +1 more source

Amyloid pathology disrupts gliotransmitter release in astrocytes.

PLoS Computational Biology, 2022
Accumulation of amyloid-beta (Aβ) is associated with synaptic dysfunction and destabilization of astrocytic calcium homeostasis. A growing body of evidence support astrocytes as active modulators of synaptic transmission via calcium-mediated ...
Anup Gopalakrishna Pillai, Suhita Nadkarni   +1 more
doaj   +1 more source