Results 11 to 20 of about 31,071 (248)
Calcium signaling in astrocytes and gliotransmitter release
Frontiers in Synaptic Neuroscience, 2023 Glia are as numerous in the brain as neurons and widely known to serve supportive roles such as structural scaffolding, extracellular ionic and neurotransmitter homeostasis, and metabolic support.
Julianna Goenaga +3 more
doaj +5 more sources
Probing the Complexities of Astrocyte Calcium Signaling [PDF]
Trends in Cell Biology, 2016 Astrocytes are abundant glial cells that tile the entire central nervous system and mediate well-established functions for neurons, blood vessels, and other glia. These ubiquitous cells display intracellular Ca(2+) signals, which have been intensely studied for 25 years. Recently, the use of improved methods has unearthed the panoply of astrocyte Ca(2+)
Sandip Patel +2 more
exaly +7 more sources
Dilation of Cortical Capillaries Is Not Related to Astrocyte Calcium Signaling [PDF]
Glia, 2022 Abstract The brain requires an adequate supply of oxygen and nutrients to maintain proper function as neuronal activity varies. This is achieved, in part, through neurovascular coupling mechanisms that mediate local increases in blood flow through the dilation of arterioles and capillaries.
Armani Del Franco +2 more
exaly +4 more sources
Advances in astrocytic calcium signaling research
Frontiers in Cellular NeuroscienceAstrocytes are the most abundant glial cells in the central nervous system. They detect neuronal activity through Ca2+ signals and thereby regulate synaptic plasticity, integrate neuronal information, and maintain extracellular homeostasis.
Yuzhu Chen +5 more
doaj +3 more sources
NeuroimmunomodulationBackground and aims: The effects of adjuvant hyperthermia on glioblastoma-associated astrocytes remain poorly characterized. This study aimed to investigate the role of the purinergic P2X7 receptor, an ATP-gated ion channel, in mediating heat ...
Qiang Wang +4 more
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Enhanced Primary Motor Cortex Astrocyte Calcium Signaling With Motor Learning [PDF]
Neural PlasticityAstrocytes form an integral part of the nervous system and are proposed to modulate neuronal circuits and behavior. The motor cortex plays a key role in the planning and execution of voluntary movements and makes key contributions to motor skill learning.
Ragunathan Padmashri, Anna Dunaevsky
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Astrocyte store-operated calcium entry is required for centrally mediated neuropathic pain [PDF]
PAIN Reports. Introduction:. Acute injuries transition to chronic neuropathic pain through central sensitization (CS), which involves plastic changes to nociceptive networks within the central nervous system.
Mariya A. Prokhorenko, Jeremy T. Smyth
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Cell Reports, 2018 Summary: Down syndrome (DS) is a genetic disorder that causes cognitive impairment. The staggering effects associated with an extra copy of human chromosome 21 (HSA21) complicates mechanistic understanding of DS pathophysiology.
Grace O. Mizuno +14 more
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Astrocytes and memory: emerging evidence and a paradigm shift [PDF]
Cell Communication and SignalingIn recent years, with the discovery of astrocytes as components of the tripartite synapse and the development of tools for manipulating astrocyte calcium events, learning and memory are no longer considered the exclusive domain of neurons; activation of ...
Sen Zhang, Qinglu Wang
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Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication. [PDF]
Cell Death Differ, 2020 Through their ability to modulate synaptic transmission, glial cells are key regulators of neuronal circuit formation and activity. Kidins220/ARMS (kinase-D interacting substrate of 220 kDa/ankyrin repeat-rich membrane spanning) is one of the key effectors of the neurotrophin pathways in neurons where it is required for differentiation, survival, and ...
Jaudon F +5 more
europepmc +5 more sources