Probing the Complexities of Astrocyte Calcium Signaling. [PDF]
Trends Cell Biol, 2016 Astrocytes are abundant glial cells that tile the entire central nervous system and mediate well-established functions for neurons, blood vessels, and other glia.
Shigetomi E, Patel S, Khakh BS.
europepmc +9 more sources
Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication. [PDF]
Cell Death Differ, 2020 Through their ability to modulate synaptic transmission, glial cells are key regulators of neuronal circuit formation and activity. Kidins220/ARMS (kinase-D interacting substrate of 220 kDa/ankyrin repeat-rich membrane spanning) is one of the key ...
Jaudon F +5 more
europepmc +8 more sources
Calcium signaling in astrocytes and gliotransmitter release
Frontiers in Synaptic Neuroscience, 2023 Glia are as numerous in the brain as neurons and widely known to serve supportive roles such as structural scaffolding, extracellular ionic and neurotransmitter homeostasis, and metabolic support.
Julianna Goenaga +3 more
doaj +5 more sources
Dilation of cortical capillaries is not related to astrocyte calcium signaling. [PDF]
Glia, 2022 AbstractThe brain requires an adequate supply of oxygen and nutrients to maintain proper function as neuronal activity varies. This is achieved, in part, through neurovascular coupling mechanisms that mediate local increases in blood flow through the dilation of arterioles and capillaries.
Del Franco AP, Chiang PP, Newman EA.
europepmc +4 more sources
Visualizing Calcium Signaling in Astrocytes [PDF]
Science Signaling, 2010 Astrocyte signaling is apparent in movies of rat brain astrocytes cultured with fluorescent calcium indicator dyes.
R. Douglas Fields
core +3 more sources
Advances in astrocytic calcium signaling research
Frontiers in Cellular NeuroscienceAstrocytes are the most abundant glial cells in the central nervous system. They detect neuronal activity through Ca2+ signals and thereby regulate synaptic plasticity, integrate neuronal information, and maintain extracellular homeostasis.
Yuzhu Chen +5 more
doaj +3 more sources
Opioid-Mediated Astrocyte–Neuron Signaling in the Nucleus Accumbens
Cells, 2019 Major hallmarks of astrocyte physiology are the elevation of intracellular calcium in response to neurotransmitters and the release of neuroactive substances (gliotransmitters) that modulate neuronal activity.
Michelle Corkrum +4 more
doaj +2 more sources
Enhanced Primary Motor Cortex Astrocyte Calcium Signaling With Motor Learning [PDF]
Neural PlasticityAstrocytes form an integral part of the nervous system and are proposed to modulate neuronal circuits and behavior. The motor cortex plays a key role in the planning and execution of voluntary movements and makes key contributions to motor skill learning.
Ragunathan Padmashri, Anna Dunaevsky
doaj +2 more sources
Astrocyte Calcium Signal and Gliotransmission in Human Brain Tissue [PDF]
Cerebral Cortex, 2012 Brain function is recognized to rely on neuronal activity and signaling processes between neurons, whereas astrocytes are generally considered to play supportive roles for proper neuronal function. However, accumulating evidence indicates that astrocytes
Perea, Gertrudis +8 more
core +4 more sources
Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise [PDF]
Advanced ScienceMajor depressive disorder (MDD) is increasingly linked to astrocyte dysfunction, yet how systemic metabolic disturbances contribute to glial alterations remains unclear.
Lina Gao +11 more
doaj +2 more sources