Results 41 to 50 of about 31,071 (248)

The Role of Astrocytic Calcium Signaling in the Aged Prefrontal Cortex [PDF]

Frontiers in Cellular Neuroscience, 2018
Aging is a lifelong process characterized by cognitive decline putatively due to structural and functional changes of neural circuits of the brain. Neuron-glial signaling is a fundamental component of structure and function of circuits of the brain, and yet its possible role in aging remains elusive.
Sónia Guerra-Gomes, Sónia Guerra-Gomes, João Filipe Viana, João Filipe Viana, Diana Sofia Marques Nascimento, Diana Sofia Marques Nascimento, Joana Sofia Correia, Joana Sofia Correia, Vanessa Morais Sardinha, Vanessa Morais Sardinha, Inês Caetano, Inês Caetano, Nuno Sousa, Nuno Sousa, Luísa Pinto, Luísa Pinto, João Filipe Oliveira, João Filipe Oliveira, João Filipe Oliveira   +18 more
openaire   +4 more sources

Calcium Signaling and Gliotransmission in Normal vs. Reactive Astrocytes [PDF]

Frontiers in Pharmacology, 2012
A prominent area of neuroscience research over the past 20 years has been the acute modulation of neuronal synaptic activity by Ca(2+)-dependent release of the transmitters ATP, D-serine, and glutamate (called gliotransmitters) by astrocytes. Although the physiological relevance of this mechanism is under debate, emerging evidence suggests that there ...
Agulhon, Cendra, Sun, Min-Yu, Murphy, Thomas, Myers, Timothy, Lauderdale, Kelli, Fiacco, Todd A.   +5 more
openaire   +3 more sources

KCa3.1 deficiency attenuates neuroinflammation by regulating an astrocyte phenotype switch involving the PI3K/AKT/GSK3β pathway

Neurobiology of Disease, 2019
Neuroinflammation may induce a phenotype switch to reactive astrogliosis in neurodegenerative disorders. The calcium-activated potassium channel (KCa3.1) is active in the phenotypic switch that occurs during astrogliosis in Alzheimer's disease and ...
Tianjiao Wei, Yanxia Wang, Weirong Xu, Yan Liu, Hongzhuan Chen, Zhihua Yu   +5 more
doaj   +1 more source

Disrupted TFEB/GDNF-cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice. [PDF]

Adv Sci (Weinh)
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Yao L, Hatami M, Koc S, Jiang Q, Skutella T, Zhang Y.   +5 more
europepmc   +2 more sources

Impact of Astrocytic Coverage of Synapses on the Short-Term Memory of a Computational Neuron-Astrocyte Network

Mathematics, 2022
Working memory refers to the capability of the nervous system to selectively retain short-term memories in an active state. The long-standing viewpoint is that neurons play an indispensable role and working memory is encoded by synaptic plasticity ...
Zonglun Li, Yuliya Tsybina, Susanna Gordleeva, Alexey Zaikin   +3 more
doaj   +1 more source

Dopamine-induced calcium signaling in olfactory bulb astrocytes [PDF]

Scientific Reports, 2020
Abstract It is well established that astrocytes respond to the major neurotransmitters glutamate and GABA with cytosolic calcium rises, whereas less is known about the effect of dopamine on astroglial cells. In the present study, we used confocal calcium imaging in mouse brain slices of the olfactory bulb, a brain
Fischer, Timo, Scheffler, Paula, Lohr, Christian   +2 more
openaire   +2 more sources

Methamphetamine Activates Trace Amine Associated Receptor 1 to Regulate Astrocyte Excitatory Amino Acid Transporter-2 via Differential CREB Phosphorylation During HIV-Associated Neurocognitive Disorders

Frontiers in Neurology, 2020
Methamphetamine (METH) use, referred to as methamphetamine use disorder (MUD), results in neurocognitive decline, a characteristic shared with HIV-associated neurocognitive disorders (HAND).
Irma E. Cisneros, Anuja Ghorpade, Kathleen Borgmann   +2 more
doaj   +1 more source

Astrocyte Calcium Signaling Shifts the Polarity of Presynaptic Plasticity

Neuroscience, 2023
Astrocytes have been increasingly acknowledged to play active roles in regulating synaptic transmission and plasticity. Through a variety of metabotropic and ionotropic receptors expressed on their surface, astrocytes detect extracellular neurotransmitters, and in turn, release gliotransmitters to modify synaptic strength, while they can also alter ...
Letellier, Mathieu, Goda, Yukiko
openaire   +3 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Contribution of astrocytic calcium signaling to auditory hypersensitivity in a mouse model of fragile X syndrome

Neurobiology of Disease
Hypersensitivity to sensory stimuli is a common co-morbidity of Fragile X syndrome (FXS), the leading monogenic form of intellectual disability and autism spectrum disorder (ASD). Neuronal impairments associated with auditory and tactile hypersensitivity
Lara Bergdolt, Alexandria Anding, Ola Alshaqi, Zahra Arbabi, Michael Douchey, Ember Eldridge, Katherine Hoffman, Ashley Reid, Kiran Sapkota, Daniel Monaghan, Olga Taraschenko, Ragunathan Padmashri, Anna Dunaevsky   +12 more
doaj   +1 more source