Results 1 to 10 of about 332,588 (287)

PHLPP1 regulates region-specific astroglial mitochondrial fission in response to oxidative stress in the male rat hippocampus [PDF]

Scientific Reports
Astrocytes have specialized functions depending on their localization. This region-dependent heterogeneity of astrocytes shows marked difference in astroglial responses to various stimuli.
Ji-Eun Kim, Su Hyeon Wang, Tae-Cheon Kang   +2 more
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Metabolic Heterogeneity of Cerebral Cortical and Cerebellar Astrocytes

Life, 2023
Astrocytes play critical roles in regulating neuronal synaptogenesis, maintaining blood–brain barrier integrity, and recycling neurotransmitters. Increasing numbers of studies have suggested astrocyte heterogeneity in morphology, gene profile, and ...
Yuanhong Sun, Ali Winters, Linshu Wang, Kiran Chaudhari, Raymond Berry, Christina Tang, Ran Liu, Shaohua Yang   +7 more
doaj   +1 more source

Isolation of ferret astrocytes reveals their morphological, transcriptional, and functional differences from mouse astrocytes

Frontiers in Cellular Neuroscience, 2022
Astrocytes play key roles in supporting the central nervous system structure, regulating synaptic functions, and maintaining brain homeostasis. The number of astrocytes in the cerebrum has markedly increased through evolution.
Jureepon Roboon, Tsuyoshi Hattori, Dinh Thi Nguyen, Hiroshi Ishii, Mika Takarada-Iemata, Takayuki Kannon, Kazuyoshi Hosomichi, Takashi Maejima, Kengo Saito, Yohei Shinmyo, Michihiro Mieda, Atsushi Tajima, Hiroshi Kawasaki, Osamu Hori   +13 more
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The origins and dynamic changes of C3- and S100A10-positive reactive astrocytes after spinal cord injury

Frontiers in Cellular Neuroscience, 2023
Accaumulating studies focus on the effects of C3-positive A1-like phenotypes and S100A10-positive A2-like phenotypes of reactive astrocytes on spinal cord injury (SCI), however the origins and dynamic changes of C3- and S100A10-positive reactive ...
Qing Zhao, Qing Zhao, Yi-long Ren, Yi-long Ren, Yan-jing Zhu, Rui-qi Huang, Rong-rong Zhu, Li-ming Cheng, Li-ming Cheng, Li-ming Cheng, Ning Xie, Ning Xie   +11 more
doaj   +1 more source

D1- and D2-type dopamine receptors are immunolocalized in pial and layer I astrocytes in the rat cerebral cortex

Frontiers in Neuroanatomy, 2023
Pial astrocytes, a cellular component of the cerebral cortex surface structure, are observed in a wide range of mammalian species. Despite being recognized as such, the functional potential of pial astrocytes has long been overlooked.
Satoko Oda, Hiromasa Funato, Hiromasa Funato   +2 more
doaj   +1 more source

Differential Proliferation and Maturation of Subcortical Astrocytes During Postnatal Development

Frontiers in Neuroscience, 2020
Astrocytes exhibit a region-dependent molecular and functional heterogeneity in the CNS. Although cortical astrocytes proliferate robustly during the first postnatal week and become proliferation quiescent, the temporal proliferation dynamics of ...
Temitope Shoneye, Alessandra Tamashiro Orrego, Rachel Jarvis, Yuqin Men, Ming Sum R. Chiang, Yongjie Yang, Yongjie Yang   +6 more
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Activation of a neural stem cell transcriptional program in parenchymal astrocytes

eLife, 2020
Adult neural stem cells, located in discrete brain regions, generate new neurons throughout life. These stem cells are specialized astrocytes, but astrocytes in other brain regions do not generate neurons under physiological conditions.
Jens P Magnusson, Margherita Zamboni, Giuseppe Santopolo, Jeff E Mold, Mauricio Barrientos-Somarribas, Carlos Talavera-Lopez, Björn Andersson, Jonas Frisén   +7 more
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Characterization of Vimentin-Immunoreactive Astrocytes in the Human Brain

Frontiers in Neuroanatomy, 2020
Astrocytes are commonly identified by their expression of the intermediate filament protein glial fibrillary acidic protein (GFAP). GFAP-immunoreactive (GFAP-IR) astrocytes exhibit regional heterogeneity in density and morphology in the mouse brain as ...
Liam Anuj O’Leary, Liam Anuj O’Leary, Maria Antonietta Davoli, Claudia Belliveau, Claudia Belliveau, Arnaud Tanti, Jie Christopher Ma, William Todd Farmer, Gustavo Turecki, Gustavo Turecki, Gustavo Turecki, Keith Kazuo Murai, Naguib Mechawar, Naguib Mechawar, Naguib Mechawar   +14 more
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Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury

Cell Communication and Signaling, 2023
Background Limited progress in terms of an effective treatment for spinal cord injury (SCI) emphasizes the urgent need for novel therapies. As a vital central nervous system component, the resident astrocytes play crucial roles in regulating recovery ...
Jie Chang, Zhanyang Qian, Binyu Wang, Jiang Cao, Sheng Zhang, Fan Jiang, Renyi Kong, Xiao Yu, Xiaojian Cao, Lei Yang, Hongtao Chen   +10 more
doaj   +1 more source

TXNIP contributes to induction of pro-inflammatory phenotype and caspase-3 activation in astrocytes during Alzheimer’s diseases

Redox Biology, 2023
Neuroinflammation and oxidative stress have been implicated in the pathogenesis of Alzheimer’s disease (AD). Neuroinflammation and oxidative stress are associated with neuronal death in AD. Astrocytes are linked to neuroinflammation during AD. Astrocytes
Junhyung Kim, Jaejoon Lim, Ik Dong Yoo, Samel Park, Jong-Seok Moon   +4 more
doaj   +1 more source