Results 1 to 10 of about 185,860 (239)
An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells [PDF]
Stem Cell Reports, 2017 Summary: Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from ...
Julia TCW +13 more
doaj +4 more sources
Metabolic Heterogeneity of Cerebral Cortical and Cerebellar Astrocytes
Life, 2023 Astrocytes play critical roles in regulating neuronal synaptogenesis, maintaining blood–brain barrier integrity, and recycling neurotransmitters. Increasing numbers of studies have suggested astrocyte heterogeneity in morphology, gene profile, and ...
Yuanhong Sun +7 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 Astrocytes play key roles in supporting the central nervous system structure, regulating synaptic functions, and maintaining brain homeostasis. The number of astrocytes in the cerebrum has markedly increased through evolution.
Jureepon Roboon +13 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2023 Accaumulating studies focus on the effects of C3-positive A1-like phenotypes and S100A10-positive A2-like phenotypes of reactive astrocytes on spinal cord injury (SCI), however the origins and dynamic changes of C3- and S100A10-positive reactive ...
Qing Zhao +11 more
doaj +1 more source
Frontiers in Neuroanatomy, 2023 Pial astrocytes, a cellular component of the cerebral cortex surface structure, are observed in a wide range of mammalian species. Despite being recognized as such, the functional potential of pial astrocytes has long been overlooked.
Satoko Oda +2 more
doaj +1 more source
Differential Proliferation and Maturation of Subcortical Astrocytes During Postnatal Development
Frontiers in Neuroscience, 2020 Astrocytes exhibit a region-dependent molecular and functional heterogeneity in the CNS. Although cortical astrocytes proliferate robustly during the first postnatal week and become proliferation quiescent, the temporal proliferation dynamics of ...
Temitope Shoneye +6 more
doaj +1 more source
Activation of a neural stem cell transcriptional program in parenchymal astrocytes
eLife, 2020 Adult neural stem cells, located in discrete brain regions, generate new neurons throughout life. These stem cells are specialized astrocytes, but astrocytes in other brain regions do not generate neurons under physiological conditions.
Jens P Magnusson +7 more
doaj +1 more source
Characterization of Vimentin-Immunoreactive Astrocytes in the Human Brain
Frontiers in Neuroanatomy, 2020 Astrocytes are commonly identified by their expression of the intermediate filament protein glial fibrillary acidic protein (GFAP). GFAP-immunoreactive (GFAP-IR) astrocytes exhibit regional heterogeneity in density and morphology in the mouse brain as ...
Liam Anuj O’Leary +14 more
doaj +1 more source
The multifaceted role of astrocytes in regulating myelination [PDF]
, 2016 Astrocytes are the major glial cell of the central nervous system (CNS), providing both metabolic and physical support to other neural cells. After injury, astrocytes become reactive and express a continuum of phenotypes which may be supportive or ...
Barnett, Susan C. +3 more
core +7 more sources
Cell Communication and Signaling, 2023 Background Limited progress in terms of an effective treatment for spinal cord injury (SCI) emphasizes the urgent need for novel therapies. As a vital central nervous system component, the resident astrocytes play crucial roles in regulating recovery ...
Jie Chang +10 more
doaj +1 more source