An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells [PDF]
Stem Cell Reports, 2017 Summary: Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from ...
Julia TCW +13 more
doaj +4 more sources
Differential sensitivity of brainstem vs cortical astrocytes to changes in pH reveals functional regional specialization of astroglia [PDF]
, 2013 Astrocytes might function as brain interoceptors capable of detecting different (chemo)sensory modalities and transmitting sensory information to the relevant neural networks controlling vital functions.
Castaldo, C +6 more
core +1 more source
Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection [PDF]
, 2017 Type I IFNs promote cellular responses to viruses, and IFN receptor (IFNAR) signaling regulates the responses of endothelial cells of the blood-brain barrier (BBB) during neurotropic viral infection.
Ali +23 more
core +3 more sources
Journal of Neuroinflammation, 2020 Background Evidence shows significant heterogeneity in astrocyte gene expression and function. We previously demonstrated that brain-derived neurotrophic factor (BDNF) exerts protective effects on whole brain primary cultured rat astrocytes treated with ...
Julieta Saba +7 more
doaj +1 more source
Olig2-astrocytes express neutral amino acid transporter SLC7A10 (Asc-1) in the adult brain
Molecular Brain, 2021 We have reported that the transcription factor Olig2 labels a subpopulation of astrocytes (Olig2-astrocytes), which show distribution patterns different from those of GFAP-expressing astrocytes (GFAP-astrocytes) in the adult brain.
Kouko Tatsumi +8 more
doaj +1 more source
Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor. [PDF]
, 2014 Although astrocytes are the most abundant cell type in the central nervous system (CNS), little is known about their molecular specification and differentiation.
Chen, Yidan +10 more
core +7 more sources
Unperturbed posttranscriptional regulatory Rev protein function and HIV-1 replication in astrocytes. [PDF]
PLoS ONE, 2014 Astrocytes protect neurons, but also evoke proinflammatory responses to injury and viral infections, including HIV. There is a prevailing notion that HIV-1 Rev protein function in astrocytes is perturbed, leading to restricted viral replication.
Ashok Chauhan
doaj +1 more source
Alteration of dentate gyrus astrocytes in diabetic rats: Protective role of Urtica dioica [PDF]
, 2011 Diabetes mellitus can cause astrocytes alterations in the central nervous system. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine.
Ghafari, S. +3 more
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Journal of Neuroinflammation, 2023 Objective Patients with hypertension have a risk of depression. Morinda officinalis oligosaccharides (MOOs) have anti-depressant properties. In this study, we aimed to determine whether MOOs can improve the symptoms of depression in individuals with ...
Lixuan Yang +9 more
doaj +1 more source
The preventive and treatment effect of Urtica dioica on astrocyte density in the CA1 and CA3 subfields of hippocampus in STZ induced diabetic rats [PDF]
, 2013 Several animal model studies have shown that Diabetes mellitus can affect on the activity of hippocampus astrocytes, but these studies reported controversial findings.
Afshar, M. +3 more
core +1 more source