Results 11 to 20 of about 196,706 (255)

Astrocytes Imagined

Journal of Integrative Neuroscience, 2022
The cellular, molecular and physiological basis of cognition has proved elusive until emerging studies on astrocytes. The appearance of a deliberate aggregating element in cellular neurophysiology was difficult to satisfy computationally with excitatory and inhibitory neuron physiology alone.
openaire   +3 more sources

Olig2-Lineage Astrocytes: A Distinct Subtype of Astrocytes That Differs from GFAP Astrocytes

Frontiers in Neuroanatomy, 2018
Astrocytes are the most abundant glia cell type in the central nervous system (CNS), and are known to constitute heterogeneous populations that differ in their morphology, gene expression and function.
Kouko Tatsumi, Ayami Isonishi, Miwako Yamasaki, Yoshie Kawabe, Shoko Morita-Takemura, Kazuki Nakahara, Yuki Terada, Takeaki Shinjo, Hiroaki Okuda, Tatsuhide Tanaka, Akio Wanaka   +10 more
doaj   +1 more source

Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy

Journal of Neuroinflammation, 2023
Objective Patients with hypertension have a risk of depression. Morinda officinalis oligosaccharides (MOOs) have anti-depressant properties. In this study, we aimed to determine whether MOOs can improve the symptoms of depression in individuals with ...
Lixuan Yang, Yutian Ao, Yannan Li, Baoan Dai, Jingchun Li, Wenzhe Duan, Wei Gao, Zhonghui Zhao, Zhenyun Han, Rongjuan Guo   +9 more
doaj   +1 more source

Olig2-astrocytes express neutral amino acid transporter SLC7A10 (Asc-1) in the adult brain

Molecular Brain, 2021
We have reported that the transcription factor Olig2 labels a subpopulation of astrocytes (Olig2-astrocytes), which show distribution patterns different from those of GFAP-expressing astrocytes (GFAP-astrocytes) in the adult brain.
Kouko Tatsumi, Kaoru Kinugawa, Ayami Isonishi, Masahiro Kitabatake, Hiroaki Okuda, Shoko Takemura, Tatsuhide Tanaka, Eiichiro Mori, Akio Wanaka   +8 more
doaj   +1 more source

Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: implications for protection of striatal neurons expressing mutant huntingtin

Journal of Neuroinflammation, 2020
Background Evidence shows significant heterogeneity in astrocyte gene expression and function. We previously demonstrated that brain-derived neurotrophic factor (BDNF) exerts protective effects on whole brain primary cultured rat astrocytes treated with ...
Julieta Saba, Federico López Couselo, Juan Turati, Lila Carniglia, Daniela Durand, Andrea de Laurentiis, Mercedes Lasaga, Carla Caruso   +7 more
doaj   +1 more source

Small-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes

Cell Reports, 2016
Growing evidence indicates important roles for astrocytes in neurodevelopment and diseases. However, astrocytes and their roles in these processes remain poorly understood.
E Tian, Guoqiang Sun, Guihua Sun, Jianfei Chao, Peng Ye, Charles Warden, Arthur D. Riggs, Yanhong Shi   +7 more
doaj   +1 more source

Extracellular Neuroleukin Enhances Neuroleukin Secretion From Astrocytes and Promotes Axonal Growth in vitro and in vivo

Frontiers in Pharmacology, 2018
Under pathological conditions in the central nervous system (CNS), including spinal cord injury, astrocytes show detrimental effects against neurons.
Yoshitaka Tanie, Norio Tanabe, Tomoharu Kuboyama, Chihiro Tohda   +3 more
doaj   +1 more source

An update on reactive astrocytes in chronic pain

Journal of Neuroinflammation, 2019
Chronic pain is a critical clinical problem with an increasing prevalence. However, there are limited effective prevention measures and treatments for chronic pain.
Ting Li, Xuhui Chen, Chuanhan Zhang, Yue Zhang, Wenlong Yao   +4 more
doaj   +1 more source

Alterations of gene expression and glutamate clearance in astrocytes derived from an MeCP2-null mouse model of Rett syndrome. [PDF]

PLoS ONE, 2012
Rett syndrome (RTT) is a neurodevelopmetal disorder associated with mutations in the methyl-CpG-binding protein 2 (MeCP2) gene. MeCP2-deficient mice recapitulate the neurological degeneration observed in RTT patients.
Yasunori Okabe, Tomoyuki Takahashi, Chiaki Mitsumasu, Ken-ichiro Kosai, Eiichiro Tanaka, Toyojiro Matsuishi   +5 more
doaj   +1 more source

Gene expression profiles of reactive astrocytes cultured from dopamine-depleted striatum

Neurobiology of Disease, 2005
We have carried out cDNA array analysis in order to characterize the gene expression profiles of reactive astrocytes from dopamine-depleted striatum.
Takao Nakagawa, Takeshi Yabe, Joan P. Schwartz   +2 more
doaj   +1 more source