Results 21 to 30 of about 123,114 (319)
Frontiers in Aging Neuroscience, 2018 By 2050, the aging population is predicted to expand by over 100%. Considering this rapid growth, and the additional strain it will place on healthcare resources because of age-related impairments, it is vital that researchers gain a deeper understanding of the cellular interactions that occur with normal aging.
Alexandra L. Palmer +2 more
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The Synucleins and the Astrocyte
Biology, 2023 Synucleins consist of three proteins exclusively expressed in vertebrates. α-Synuclein (αS) has been identified as the main proteinaceous aggregate in Lewy bodies, a pathological hallmark of many neurodegenerative diseases. Less is understood about β-synuclein (βS) and γ-synuclein (γS), although it is known βS can interact with αS in vivo to inhibit ...
Abigail J. Myers +3 more
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COVID‐19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1953-1961, December 2022., 2022 Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic has had an unprecedented impact on the healthcare system, economy, and society. Studies have reported that COVID‐19 may cause various neurologic symptoms, including cognitive impairment.
Hanyu Zhang, Zengyuan Zhou
wiley +1 more source
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, 2009 AbstractSecretion is a universal cellular process occurring in bakers yeast, to the complex multicellular organisms, to humans beings. Neurotransmission, digestion, immune response or the release of hormones occur as a result of cell secretion. Secretory defects result in numerous diseases and hence a molecular understanding of the process is critical.
Won Jin Cho +4 more
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Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
Translational Neurodegeneration, 2020 Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Microglia and astrocytes are key regulators of inflammatory responses in the central nervous system. The
H. S. Kwon, S. Koh
semanticscholar +1 more source
Nature Communications, 2022 Alzheimer’s disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and MAPTP301S tauopathy mice revealed that only Aß influenced expression of AD
Zoeb Jiwaji +30 more
semanticscholar +1 more source
Progress in Neurobiology, 2008 Neurons have long held the spotlight as the central players of the nervous system, but we must remember that we have equal numbers of astrocytes and neurons in the brain. Are these cells only filling up the space and passively nurturing the neurons, or do they also contribute to information transfer and processing?
Doris D. Wang, Angélique Bordey
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Emergent dynamics in an astrocyte-neuronal network coupled via nitric oxide [PDF]
, 2022 In the brain, both neurons and glial cells work in conjunction with each other during information processing. Stimulation of neurons can cause calcium oscillations in astrocytes which in turn can affect neuronal calcium dynamics. The "glissandi" effect is one such phenomenon, associated with a decrease in infraslow fluctuations, in which synchronized ...
arxiv +1 more source
Cell Communication and Signaling, 2023 Background Limited progress in terms of an effective treatment for spinal cord injury (SCI) emphasizes the urgent need for novel therapies. As a vital central nervous system component, the resident astrocytes play crucial roles in regulating recovery ...
Jie Chang +10 more
doaj +1 more source