Results 21 to 30 of about 303,459 (207)

Characterization of Vimentin-Immunoreactive Astrocytes in the Human Brain

Frontiers in Neuroanatomy, 2020
Astrocytes are commonly identified by their expression of the intermediate filament protein glial fibrillary acidic protein (GFAP). GFAP-immunoreactive (GFAP-IR) astrocytes exhibit regional heterogeneity in density and morphology in the mouse brain as ...
Liam Anuj O’Leary, Liam Anuj O’Leary, Maria Antonietta Davoli, Claudia Belliveau, Claudia Belliveau, Arnaud Tanti, Jie Christopher Ma, William Todd Farmer, Gustavo Turecki, Gustavo Turecki, Gustavo Turecki, Keith Kazuo Murai, Naguib Mechawar, Naguib Mechawar, Naguib Mechawar   +14 more
doaj   +1 more source

Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury

Cell Communication and Signaling, 2023
Background Limited progress in terms of an effective treatment for spinal cord injury (SCI) emphasizes the urgent need for novel therapies. As a vital central nervous system component, the resident astrocytes play crucial roles in regulating recovery ...
Jie Chang, Zhanyang Qian, Binyu Wang, Jiang Cao, Sheng Zhang, Fan Jiang, Renyi Kong, Xiao Yu, Xiaojian Cao, Lei Yang, Hongtao Chen   +10 more
doaj   +1 more source

TXNIP contributes to induction of pro-inflammatory phenotype and caspase-3 activation in astrocytes during Alzheimer’s diseases

Redox Biology, 2023
Neuroinflammation and oxidative stress have been implicated in the pathogenesis of Alzheimer’s disease (AD). Neuroinflammation and oxidative stress are associated with neuronal death in AD. Astrocytes are linked to neuroinflammation during AD. Astrocytes
Junhyung Kim, Jaejoon Lim, Ik Dong Yoo, Samel Park, Jong-Seok Moon   +4 more
doaj   +1 more source

Olig2-Lineage Astrocytes: A Distinct Subtype of Astrocytes That Differs from GFAP Astrocytes

Frontiers in Neuroanatomy, 2018
Astrocytes are the most abundant glia cell type in the central nervous system (CNS), and are known to constitute heterogeneous populations that differ in their morphology, gene expression and function.
Kouko Tatsumi, Ayami Isonishi, Miwako Yamasaki, Yoshie Kawabe, Shoko Morita-Takemura, Kazuki Nakahara, Yuki Terada, Takeaki Shinjo, Hiroaki Okuda, Tatsuhide Tanaka, Akio Wanaka   +10 more
doaj   +1 more source

Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: implications for protection of striatal neurons expressing mutant huntingtin

Journal of Neuroinflammation, 2020
Background Evidence shows significant heterogeneity in astrocyte gene expression and function. We previously demonstrated that brain-derived neurotrophic factor (BDNF) exerts protective effects on whole brain primary cultured rat astrocytes treated with ...
Julieta Saba, Federico López Couselo, Juan Turati, Lila Carniglia, Daniela Durand, Andrea de Laurentiis, Mercedes Lasaga, Carla Caruso   +7 more
doaj   +1 more source

Olig2-astrocytes express neutral amino acid transporter SLC7A10 (Asc-1) in the adult brain

Molecular Brain, 2021
We have reported that the transcription factor Olig2 labels a subpopulation of astrocytes (Olig2-astrocytes), which show distribution patterns different from those of GFAP-expressing astrocytes (GFAP-astrocytes) in the adult brain.
Kouko Tatsumi, Kaoru Kinugawa, Ayami Isonishi, Masahiro Kitabatake, Hiroaki Okuda, Shoko Takemura, Tatsuhide Tanaka, Eiichiro Mori, Akio Wanaka   +8 more
doaj   +1 more source

Unperturbed posttranscriptional regulatory Rev protein function and HIV-1 replication in astrocytes. [PDF]

PLoS ONE, 2014
Astrocytes protect neurons, but also evoke proinflammatory responses to injury and viral infections, including HIV. There is a prevailing notion that HIV-1 Rev protein function in astrocytes is perturbed, leading to restricted viral replication.
Ashok Chauhan
doaj   +1 more source

Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy

Journal of Neuroinflammation, 2023
Objective Patients with hypertension have a risk of depression. Morinda officinalis oligosaccharides (MOOs) have anti-depressant properties. In this study, we aimed to determine whether MOOs can improve the symptoms of depression in individuals with ...
Lixuan Yang, Yutian Ao, Yannan Li, Baoan Dai, Jingchun Li, Wenzhe Duan, Wei Gao, Zhonghui Zhao, Zhenyun Han, Rongjuan Guo   +9 more
doaj   +1 more source

Interaction of Microglia and Astrocytes in the Neurovascular Unit

Frontiers in Immunology, 2020
The interaction between microglia and astrocytes significantly influences neuroinflammation. Microglia/astrocytes, part of the neurovascular unit (NVU), are activated by various brain insults.
Lirong Liu, Jia-chen Liu, Jin-shuang Bao, Qinqin Bai, Gai-qing Wang   +4 more
semanticscholar   +1 more source

Extracellular Neuroleukin Enhances Neuroleukin Secretion From Astrocytes and Promotes Axonal Growth in vitro and in vivo

Frontiers in Pharmacology, 2018
Under pathological conditions in the central nervous system (CNS), including spinal cord injury, astrocytes show detrimental effects against neurons.
Yoshitaka Tanie, Norio Tanabe, Tomoharu Kuboyama, Chihiro Tohda   +3 more
doaj   +1 more source