Results 31 to 40 of about 303,608 (351)
Epilepsia, 2010 Abstract Glia, Greek for “glue,” was discovered by Rudolph Virchow, a German anatomist, in the mid-nineteenth century. The name reflects the original view that glia played merely a structural or metabolic support role for neurons. Glial cells, especially astrocytes, are much more than glue or merely quiescent and display their own set of
Jerome Clasadonte, Philip G. Haydon
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Frontiers in Aging Neuroscience, 2018 By 2050, the aging population is predicted to expand by over 100%. Considering this rapid growth, and the additional strain it will place on healthcare resources because of age-related impairments, it is vital that researchers gain a deeper understanding of the cellular interactions that occur with normal aging.
Alexandra L. Palmer +2 more
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The Synucleins and the Astrocyte
Biology, 2023 Synucleins consist of three proteins exclusively expressed in vertebrates. α-Synuclein (αS) has been identified as the main proteinaceous aggregate in Lewy bodies, a pathological hallmark of many neurodegenerative diseases. Less is understood about β-synuclein (βS) and γ-synuclein (γS), although it is known βS can interact with αS in vivo to inhibit ...
Abigail J. Myers +3 more
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Differential Proliferation and Maturation of Subcortical Astrocytes During Postnatal Development
Frontiers in Neuroscience, 2020 Astrocytes exhibit a region-dependent molecular and functional heterogeneity in the CNS. Although cortical astrocytes proliferate robustly during the first postnatal week and become proliferation quiescent, the temporal proliferation dynamics of ...
Temitope Shoneye +6 more
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Astrocytes as Key Regulators of Brain Energy Metabolism: New Therapeutic Perspectives
Frontiers in Physiology, 2022 Astrocytes play key roles in the regulation of brain energy metabolism, which has a major impact on brain functions, including memory, neuroprotection, resistance to oxidative stress and homeostatic tone.
Elidie Béard +4 more
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Nature Communications, 2022 Alzheimer’s disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and MAPTP301S tauopathy mice revealed that only Aß influenced expression of AD
Zoeb Jiwaji +30 more
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Journal of Cellular and Molecular Medicine, 2009 AbstractSecretion is a universal cellular process occurring in bakers yeast, to the complex multicellular organisms, to humans beings. Neurotransmission, digestion, immune response or the release of hormones occur as a result of cell secretion. Secretory defects result in numerous diseases and hence a molecular understanding of the process is critical.
Won Jin Cho +4 more
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Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
Translational Neurodegeneration, 2020 Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Microglia and astrocytes are key regulators of inflammatory responses in the central nervous system. The
H. S. Kwon, S. Koh
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Activation of a neural stem cell transcriptional program in parenchymal astrocytes
eLife, 2020 Adult neural stem cells, located in discrete brain regions, generate new neurons throughout life. These stem cells are specialized astrocytes, but astrocytes in other brain regions do not generate neurons under physiological conditions.
Jens P Magnusson +7 more
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Progress in Neurobiology, 2008 Neurons have long held the spotlight as the central players of the nervous system, but we must remember that we have equal numbers of astrocytes and neurons in the brain. Are these cells only filling up the space and passively nurturing the neurons, or do they also contribute to information transfer and processing?
Doris D. Wang, Angélique Bordey
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