Results 41 to 50 of about 123,114 (319)
Journal of Integrative Neuroscience, 2022 The cellular, molecular and physiological basis of cognition has proved elusive until emerging studies on astrocytes. The appearance of a deliberate aggregating element in cellular neurophysiology was difficult to satisfy computationally with excitatory and inhibitory neuron physiology alone.
openaire +3 more sources
A tale of two stories: astrocyte regulation of synaptic depression and facilitation [PDF]
PLoS Comput. Biol. (2011) 7(12): e1002293, 2011 Short-term presynaptic plasticity designates variations of the amplitude of synaptic information transfer whereby the amount of neurotransmitter released upon presynaptic stimulation changes over seconds as a function of the neuronal firing activity. While a consensus has emerged that changes of the synapse strength are crucial to neuronal computations,
arxiv +1 more source
Journal of Neuroscience, 2008 Understanding the cell–cell interactions that control CNS development and function has long been limited by the lack of methods to cleanly separate neural cell types.
John D. Cahoy +11 more
semanticscholar +1 more source
Astrocytes: a double-edged sword in neurodegenerative diseases
Neural Regeneration Research, 2021 Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the central nervous system by regulating homeostasis, increasing synaptic plasticity, and sustaining neuroprotective effects.
Z. Ding +5 more
semanticscholar +1 more source
Alterations of gene expression and glutamate clearance in astrocytes derived from an MeCP2-null mouse model of Rett syndrome. [PDF]
PLoS ONE, 2012 Rett syndrome (RTT) is a neurodevelopmetal disorder associated with mutations in the methyl-CpG-binding protein 2 (MeCP2) gene. MeCP2-deficient mice recapitulate the neurological degeneration observed in RTT patients.
Yasunori Okabe +5 more
doaj +1 more source
Activation and Role of Astrocytes in Ischemic Stroke
Frontiers in Cellular Neuroscience, 2021 Ischemic stroke refers to the disorder of blood supply of local brain tissue caused by various reasons. It has high morbidity and mortality worldwide. Astrocytes are the most abundant glial cells in the central nervous system (CNS).
Xin-Ya Shen +5 more
semanticscholar +1 more source
Widespread Decrease of Cerebral Vimentin-Immunoreactive Astrocytes in Depressed Suicides
Frontiers in Psychiatry, 2021 Post-mortem investigations have implicated cerebral astrocytes immunoreactive (-IR) for glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide.
Liam Anuj O'Leary +12 more
doaj +1 more source
Olig2-astrocytes express neutral amino acid transporter SLC7A10 (Asc-1) in the adult brain
Molecular Brain, 2021 We have reported that the transcription factor Olig2 labels a subpopulation of astrocytes (Olig2-astrocytes), which show distribution patterns different from those of GFAP-expressing astrocytes (GFAP-astrocytes) in the adult brain.
Kouko Tatsumi +8 more
doaj +1 more source
Frontiers in Pharmacology, 2018 Under pathological conditions in the central nervous system (CNS), including spinal cord injury, astrocytes show detrimental effects against neurons.
Yoshitaka Tanie +3 more
doaj +1 more source
Neuron-Astrocyte Associative Memory [PDF]
arXiv, 2023 Astrocytes, the most abundant type of glial cell, play a fundamental role in memory. Despite most hippocampal synapses being contacted by an astrocyte, there are no current theories that explain how neurons, synapses, and astrocytes might collectively contribute to memory function.
arxiv