Results 41 to 50 of about 371,392 (310)

A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment

Journal of Neuroinflammation, 2020
Background Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying the effects remain unclear.
He-Yang Zhang, Yan Wang, Youdi He, Ting Wang, Xiao-Hui Huang, Chang-Ming Zhao, Lei Zhang, Si-Wei Li, Changyong Wang, Yan-Nv Qu, Xiao-Xia Jiang   +10 more
doaj   +1 more source

Widespread Decrease of Cerebral Vimentin-Immunoreactive Astrocytes in Depressed Suicides

Frontiers in Psychiatry, 2021
Post-mortem investigations have implicated cerebral astrocytes immunoreactive (-IR) for glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide.
Liam Anuj O'Leary, Liam Anuj O'Leary, Claudia Belliveau, Claudia Belliveau, Maria Antonietta Davoli, Jie Christopher Ma, Arnaud Tanti, Gustavo Turecki, Gustavo Turecki, Gustavo Turecki, Naguib Mechawar, Naguib Mechawar, Naguib Mechawar   +12 more
doaj   +1 more source

Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan, Ya‐Fang Chen, Cheng‐Hsuan Li, Yih‐Chih Kuo, Ni‐Chung Lee, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Tai‐Chung Tseng, Tung‐Hung Su, Chien‐Ting Hsu, Huey‐Ling Chen, Chin‐Hsien Lin, Yen‐Hsuan Ni   +12 more
wiley   +1 more source

Hydrogen Peroxide-Induced Thymidine Incorporation Into Cultured Rat Astrocytes

Journal of Pharmacological Sciences, 2006
We characterized [methyl-3H]thymidine ([3H]thymidine) and [5-3H]uridine ([3H]uridine) incorporation into cultured astrocytes and neurons in the presence and absence of hydrogen peroxide (H2O2) in order to define the response to oxidative stress in the ...
Koh-ichi Tanaka, Tomoaki Sato, Yoshiko Ohnishi, Takashige Nishikawa   +3 more
doaj   +1 more source

Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease

Journal of Pharmacological Sciences, 2020
The pathophysiological roles of astrocytes in the reactive state are thought to have important significance in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD).
Moonseok Choi, Hyunju Kim, Eun-Jeong Yang, Hye-Sun Kim   +3 more
doaj   +1 more source

Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization. [PDF]

, 2019
Glaucoma is characterized by a progressive optic nerve degeneration and retinal ganglion cell loss, but the underlying biological basis for the accompanying neurodegeneration is not known.
Ahn, Sangphil, Edwards, Genea, Ju, Won-Kyu, Kim, Keun-Young, Park, Tae Lim, Shim, Myoung Sup, Weinreb, Robert N   +6 more
core   +1 more source

Analysis of Soluble Interleukin‐2 Receptor as a Prognostic Biomarker in NMOSD and MOGAD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Soluble interleukin‐2 receptor (sIL‐2R) is a biomarker for T cell activity. T cells are involved in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) pathogenesis. However, sIL‐2R has so far not been evaluated in these conditions.
Philipp Klyscz, Carolin Otto, Klemens Ruprecht, Susanna Asseyer, Hannes Ole Tiedt, Christian Meisel, Judith Bellmann‐Strobl, Friedemann Paul, Patrick Schindler   +8 more
wiley   +1 more source

New Insights into GFAP Negative Astrocytes in Calbindin D28k Immunoreactive Astrocytes

Brain Sciences, 2018
Glial fibrillary acidic protein (GFAP) is commonly used as a specific marker for the identification of astrocytes. Nevertheless, it is known from the literature that astrocytes in situ in contrast to cultured astrocytes may feature lower levels of GFAP ...
Jie Xu
doaj   +1 more source

Astrocytes: GABAceptive and GABAergic Cells in the Brain

Frontiers in Cellular Neuroscience, 2022
Astrocytes, the most numerous glial cells in the brain, play an important role in preserving normal neural functions and mediating the pathogenesis of neurological disorders.
Jianhui Liu, Xuanran Feng, Yi Wang, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng   +11 more
doaj   +1 more source

Glutamate induces autophagy via the two-pore channels in neural cells [PDF]

, 2016
NAADP (nicotinic acid adenine dinucleotide phosphate) has been proposed as a second messenger for glutamate in neuronal and glial cells via the activation of the lysosomal Ca2+ channels TPC1 and TPC2.
 , ,, Antonioli, M, Bincoletto, C, Fimia, G, Hirata, H, Nascimento, A, Pereira, G, Piacentini, M, Smaili, S, Ureshino, R, Vescovo, T   +11 more
core   +4 more sources