Results 41 to 50 of about 461,223 (386)

Astrocytes: a double-edged sword in neurodegenerative diseases

Neural Regeneration Research, 2021
Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the central nervous system by regulating homeostasis, increasing synaptic plasticity, and sustaining neuroprotective effects.
Z. Ding, L. Song, Qing Wang, Gajendra Kumar, Yung Yan, Cun-Gen Ma   +5 more
semanticscholar   +1 more source

Active sulforhodamine 101 uptake into hippocampal astrocytes. [PDF]

PLoS ONE, 2012
Sulforhodamine 101 (SR101) is widely used as a marker of astrocytes. In this study we investigated labeling of astrocytes by SR101 in acute slices from the ventrolateral medulla and the hippocampus of transgenic mice expressing EGFP under the control of ...
Christian Schnell, Yohannes Hagos, Swen Hülsmann   +2 more
doaj   +1 more source

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. [PDF]

, 2013
Postnatal/adult neural stem cells (NSCs) within the rodent subventricular zone (SVZ; also called subependymal zone) generate doublecortin (Dcx)(+) neuroblasts that migrate and integrate into olfactory bulb circuitry.
Abdi, Khadar, Benner, Eric, Eroglu, Cagla, Jo, Rebecca, Kuo, Chay, Liu, Chunlei, Luciano, Dominic, Paez-Gonzalez, Patricia, Sheng, Huaxin, Warner, David   +9 more
core   +1 more source

Demonstration of astrocytes in cultured amniotic fluid cells of three cases with neural-tube defect [PDF]

, 1981
We have investigated the origin of rapidly adhering (RA) cells in three cases of neural tube defects (two anencephali, one encephalocele). We were able to demonstrate the presence of glial fibrillary acidic (GFA) protein in variable percentages (4–80 ...
AD Smith, AK Buamah, B Nørgaard-Pedersen, CB Laurell, CM Gosden, CM Gosden, CM Gosden, D Bignami, E Crouch, GR Sutherland, LB Chen, LF Eng, LF Eng, M Schachner, M Schachner, M Seppälä, NJ Wald, S Sarkar, T Voigtländer   +18 more
core   +1 more source

Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release

Cells, 2019
Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in the central nervous system (CNS); however, residual glutamate in the extracellular space is, potentially, neurotoxic.
Shaimaa S. Mahmoud, M. Gharagozloo, Camille Simard, Denis Gris   +3 more
semanticscholar   +1 more source

Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells

Stem Cell Reports, 2018
Summary: Differentiation of astrocytes from human pluripotent stem cells (hPSCs) is a tedious and variable process. This hampers the study of hPSC-generated astrocytes in disease processes and drug development.
Xiang Li, Yezheng Tao, Robert Bradley, Zhongwei Du, Yunlong Tao, Linghai Kong, Yi Dong, Jeffrey Jones, Yuanwei Yan, Cole R.K. Harder, Lindsay Morgan Friedman, Magd Bilal, Brianna Hoffmann, Su-Chun Zhang   +13 more
doaj   +1 more source

Crosstalk Between Astrocytes and Microglia: An Overview

Frontiers in Immunology, 2020
Based on discoveries enabled by new technologies and analysis using novel computational tools, neuroscience can be re-conceived in terms of information exchange in dense networks of intercellular connections rather than in the context of individual ...
A. Matejuk, R. Ransohoff
semanticscholar   +1 more source

Induction of Survival of Motor Neuron (SMN) Protein Deficiency in Spinal Astrocytes by Small Interfering RNA as an In Vitro Model of Spinal Muscular Atrophy

Cells, 2022
Spinal muscular atrophy (SMA) is a motor neuron disorder leading to progressive loss of ventral horn neurons resulting in muscle wasting. Here we investigate the contribution of spinal astrocytes to the pathogenesis of late-onset SMA forms using a mouse ...
Markus Leo, Linda-Isabell Schmitt, Michael Fleischer, Rebecca Steffen, Cora Osswald, Christoph Kleinschnitz, Tim Hagenacker   +6 more
doaj   +1 more source

The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

Cell Proliferation, 2020
Central nervous system (CNS) maintains a high level of metabolism, which leads to the generation of large amounts of free radicals, and it is also one of the most vulnerable organs to oxidative stress.
Yaxing Chen, C. Qin, Jianhan Huang, Xin Tang, Chang Liu, Keru Huang, Jianguo Xu, G. Guo, A. Tong, Liangxue Zhou   +9 more
semanticscholar   +1 more source

Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease

Journal of Pharmacological Sciences, 2020
The pathophysiological roles of astrocytes in the reactive state are thought to have important significance in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD).
Moonseok Choi, Hyunju Kim, Eun-Jeong Yang, Hye-Sun Kim   +3 more
doaj   +1 more source