Results 91 to 100 of about 3,258 (176)
Synthesis of the Southern Tripeptide (C1–N12) of Sanglifehrins Using Asymmetric Organocatalysis [PDF]
, 2014 The tripeptide southern region of the novel cyclophilin binding natural product macrolides, namely sanglifehrins, is synthesized involving asymmetric organocatalysis as chirality-inducing step.
Radhika, Laghuvarapu +1 more
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Asymmetric Synthesis of 2-Arylethylamines: A Metal-Free Review of the New Millennium
Molecules2-Arylethylamines are presented in several natural bioactive compounds, as well as in nitrogen-containing drugs. Their ability to surpass the blood–brain barrier makes this family of compounds of especial interest in medicinal chemistry.
Alejandro Manchado +4 more
doaj +1 more source
Three-Component Approach to Densely Functionalized Trifluoromethyl Allenols by Asymmetric Organocatalysis. [PDF]
J Am Chem Soc, 2023 Deliaval M +3 more
europepmc +1 more source
Synthesis and use of a stable aminal derived from TsDPEN in asymmetric organocatalysis [PDF]
, 2010 A stable aminal formed stereoselectively from (R,R)-N-tosyl-1,2-diphenyl-1,2-ethylenediamine (TsDPEN) is capable of asymmetric organocatalysis of Diels-Alder and alpha-amination reactions of ...
Martin Wills +7 more
core +1 more source
Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update
Beilstein Journal of Organic Chemistry, 2016 Oxindole scaffolds are prevalent in natural products and have been recognized as privileged substructures in new drug discovery. Several oxindole-containing compounds have advanced into clinical trials for the treatment of different diseases. Among these
Bin Yu +3 more
doaj +1 more source
CHIMIA, 2007 This mini-review concerns the broad application of (S)- and (R)-5-pyrrolidin-2-yl-1H-tetrazoles as organocatalysts. A summary of methods for their synthesis is followed by a discussion of the general reaction mechanism and subsequent analysis of
Deborah A. Longbottom +2 more
doaj +1 more source
Meldrum's Acid: A Useful Platform in Asymmetric Organocatalysis [PDF]
, 2016 International audienceFor more than a hundred years, Meldrum's acid and its derivatives have proven their utility and versatility in organic synthesis. Showing very unusual properties and multiple facets of reactivity, this small architecture has become ...
Etienne Pair +7 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2009 An enantioselective route to four tricyclic amino acids and N-tosylamides, composed of a central norbornane framework with a 2-endo,3-endo-annelated pyrrolidine ring and a 5-endo-C1 or -C2 side chain, has been developed. A key intermediate was the chiral,
Matthias Breuning +6 more
doaj +1 more source
Epoxides: Small Rings to Play with under Asymmetric Organocatalysis. [PDF]
ACS Org Inorg Au, 2022 Meninno S, Lattanzi A.
europepmc +1 more source
SynOpen, 2019 A convenient and efficient method for the synthesis of (–)-bestatin, epibestatin, phebestin, and (3S,4R)-4-amino-3-hydroxy-5-phenylpentanoic acid is reported. The key step is a proline-catalyzed α-hydroxylation of an aldehyde derived from d-phenylalanine,
Vipin Kumar Jain
doaj +1 more source