Results 91 to 100 of about 395,120 (176)

Enantioselective synthesis of tricyclic amino acid derivatives based on a rigid 4-azatricyclo[5.2.1.02,6]decane skeleton

open access: yesBeilstein Journal of Organic Chemistry, 2009
An enantioselective route to four tricyclic amino acids and N-tosylamides, composed of a central norbornane framework with a 2-endo,3-endo-annelated pyrrolidine ring and a 5-endo-C1 or -C2 side chain, has been developed. A key intermediate was the chiral,
Matthias Breuning   +6 more
doaj   +1 more source

Diastereoselective Synthesis of (–)-Bestatin, Epibestatin, Phebestin and (3S,4R)-4-Amino-3-hydroxy-5-phenylpentanoic Acid from an Aldehyde Derived from d-Phenylalanine

open access: yesSynOpen, 2019
A convenient and efficient method for the synthesis of (–)-bestatin, epibestatin, phebestin, and (3S,4R)-4-amino-3-hydroxy-5-phenylpentanoic acid is reported. The key step is a proline-catalyzed α-hydroxylation of an aldehyde derived from d-phenylalanine,
Vipin Kumar Jain
doaj   +1 more source

Organocatalytic tandem Michael addition reactions: A powerful access to the enantioselective synthesis of functionalized chromenes, thiochromenes and 1,2-dihydroquinolines

open access: yesBeilstein Journal of Organic Chemistry, 2012
Enantioselective organocatalysis has become a field of central importance within asymmetric chemical synthesis and appears to be efficient approach toward the construction of complex chiral molecules from simple achiral materials in one-pot ...
Chittaranjan Bhanja   +3 more
doaj   +1 more source

(Thio)urea-mediated synthesis of functionalized six-membered rings with multiple chiral centers

open access: yesBeilstein Journal of Organic Chemistry, 2016
Organocatalysis, now running its second decade of life, is being considered one of the main tools a synthetic chemist has to perform asymmetric catalysis. In this review the synthesis of six-membered rings, that contain multiple chiral centers, either by
Giorgos Koutoulogenis   +2 more
doaj   +1 more source

Extending Highthroughput Technologies: The Automation of Mechanism Discovery Investigations into the mode and action of the thio-Michael Reaction [PDF]

open access: yes, 2010
This project concerns the investigation of the thio-Michael reaction (see scheme). The approach has employed a process development methodology to chemical discovery rather than more traditional research methods.
WALTON, SIMON
core  

Recent Developments in Asymmetric Organocatalysis

open access: yesFocus on Catalysts, 2010
The aim of this book is to cover the very recent developments in asymmetric organocatalysis, focussing on those published since the beginning of 2008. The last decade has witnessed an explosive growth in the field of asymmetric organocatalysis with an impressive amount of new catalysts, novel methodologies, and applications in numerous reaction types ...
openaire   +2 more sources

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