Results 81 to 90 of about 415,153 (176)

Enantioselective α-heterofunctionalization reactions of catalytically generated C1-Lewis base enolates

Tetrahedron Chem
Chiral Lewis base (LB) organocatalysis has emerged as a powerful covalent catalysis concept which allows for highly selective asymmetric C–C and C-heteroatom bond formations.
Magdalena Piringer, Lotte Stockhammer, Lukas Vogl, David Weinzierl, Paul Zebrowski, Mario Waser   +5 more
doaj   +1 more source

Asymmetric Synthesis of 2-Arylethylamines: A Metal-Free Review of the New Millennium

Molecules
2-Arylethylamines are presented in several natural bioactive compounds, as well as in nitrogen-containing drugs. Their ability to surpass the blood–brain barrier makes this family of compounds of especial interest in medicinal chemistry.
Alejandro Manchado, Ángel García-González, Carlos T. Nieto, David Díez, Narciso M. Garrido   +4 more
doaj   +1 more source

Synthesis of the Southern Tripeptide (C1–N12) of Sanglifehrins Using Asymmetric Organocatalysis

, 2014
The tripeptide southern region of the novel cyclophilin binding natural product macrolides, namely sanglifehrins, is synthesized involving asymmetric organocatalysis as chirality-inducing step.
Radhika, Laghuvarapu, Chandrasekhar, Srivari   +1 more
core   +1 more source

Asymmetric Organocatalysis in Water, Water in Asymmetric Organocatalysis

Water has been recognized since the beginning of organocatalysis as a convenient (co-)solvent for many reactions. Under either homogeneous or heterogeneous conditions, the presence of water might impart new properties to the catalytic system leading to ...
Solà Oller, Jordi, Jimeno, Ciril
core   +1 more source

Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update

Beilstein Journal of Organic Chemistry, 2016
Oxindole scaffolds are prevalent in natural products and have been recognized as privileged substructures in new drug discovery. Several oxindole-containing compounds have advanced into clinical trials for the treatment of different diseases. Among these
Bin Yu, Hui Xing, De-Quan Yu, Hong-Min Liu   +3 more
doaj   +1 more source

(S)- and (R)-5-Pyrrolidin-2-yl-1H-tetrazoles: Enantiomeric Organocatalysts of Broad Utility in Organic Synthesis

CHIMIA, 2007
This mini-review concerns the broad application of (S)- and (R)-5-pyrrolidin-2-yl-1H-tetrazoles as organocatalysts. A summary of methods for their synthesis is followed by a discussion of the general reaction mechanism and subsequent analysis of
Deborah A. Longbottom, Vilius Franckevičius, Steven V. Ley   +2 more
doaj   +1 more source

Three-Component Approach to Densely Functionalized Trifluoromethyl Allenols by Asymmetric Organocatalysis. [PDF]

J Am Chem Soc, 2023
Deliaval M, Jayarajan R, Eriksson L, Szabó KJ.   +3 more
europepmc   +1 more source

Enantioselective synthesis of tricyclic amino acid derivatives based on a rigid 4-azatricyclo[5.2.1.02,6]decane skeleton

Beilstein Journal of Organic Chemistry, 2009
An enantioselective route to four tricyclic amino acids and N-tosylamides, composed of a central norbornane framework with a 2-endo,3-endo-annelated pyrrolidine ring and a 5-endo-C1 or -C2 side chain, has been developed. A key intermediate was the chiral,
Matthias Breuning, Tobias Häuser, Christian Mehler, Christian Däschlein, Carsten Strohmann, Andreas Oechsner, Holger Braunschweig   +6 more
doaj   +1 more source

Non-covalent organocatalysis in asymmetric oxidative C(sp3)–H bond functionalization – broadening C–H bond coupling reactions

, 2016
Among the current huge development activities in C-H functionalization, asymmetric oxidative C(sp(3))-H bond coupling strategies have remained underrepresented. Beyond the initial examples using chiral metal complexes, the use of organocatalysis provides
Stockerl, Sebastian, Mancheño, Olga García   +1 more
core   +1 more source

Water in asymmetric organocatalytic systems: A global perspective [PDF]

, 2016
Asymmetric organocatalysis often operates under near ambient conditions, which means it is air and moisture compatible. However, in many examples water is indeed necessary for achieving excellent catalytic results.
Jimeno, Ciril
core   +1 more source