Results 41 to 50 of about 2,455 (178)

Acid‐Catalyzed Synthesis of Si‐Stereogenic Silanes

Chinese Journal of Chemistry, EarlyView.
Si‐stereogenic silanes are important structural motifs in chemical synthesis, medicinal chemistry, and materials science. However, their catalytic enantioselective synthesis has largely relied on transition‐metal catalysts. Recently, Brønsted acids have been developed as promising alternatives.
Jung Tae Han, Benjamin List
wiley   +1 more source

(2R,4R)-2-Hydroxy-4-(2-methoxyphenyl)bicyclo[3.3.1]nonan-9-one

Acta Crystallographica Section E, 2009
The title compound, C16H20O3, contains a bicyclic ring system with two chiral centers. The crystal structure is stabilized by intermolecular O—H...O hydrogen bonds.
Shuping Luo, Guangcun Zhang, Shuai Zhang, Yifeng Wang, Wei Zhang   +4 more
doaj   +1 more source

Ultra-high-throughput mapping of the chemical space of asymmetric catalysis enables accelerated reaction discovery

Nature Communications, 2023
The discovery of highly enantioselective catalysts and elucidating their generality face great challenges due to the complex multidimensional chemical space of asymmetric catalysis and inefficient screening methods.
Wenjing Nie, Qiongqiong Wan, Jian Sun, Moran Chen, Ming Gao, Suming Chen   +5 more
doaj   +1 more source

Dual‐Mode Thio‐MacMillan Organocatalysts: Stereoselective Diels–Alder Reactions or Sacrificial Self‐Cyclization to N‐Bridged Bicyclic Lactams

Chemistry – A European Journal, Volume 32, Issue 5, 2 February 2026.
The study of the Diels–Alder reaction of cinnamaldehyde and cyclopentadiene, catalyzed by chiral imidazolidine‐4‐thiones, led to the discovery of a highly regio‐ and stereoselective Michael‐addition and consecutive ring closure. Here, the imidazolidine‐4‐thione not only catalytically activates cinnamaldehyde but also participates as the nucleophile to ...
Marian S. R. Ebeling, Luca V. Parziale, Marc Sachsenhauser, Christoph J. B. Seifert, Nathalie J. Kurrle, Oliver Trapp   +5 more
wiley   +1 more source

Biocatalytic Asymmetric Michael Addition of Thiols to α,β‐Unsaturated Aldehydes via Enzyme‐Bound Iminium Ion Intermediates

Advanced Synthesis &Catalysis, Volume 368, Issue 3, February 2026.
Biocatalytic stereo‐controlled C–S bond formation unlocked! Engineered, cofactor‐independent 4‐oxalocrotonate tautomerase variants catalyze enantioselective thia‐Michael additions of aliphatic thiols to cinnamaldehyde, affording (R)‐β‐thioenals with up to 99% conversion and high enantiopurity (up to 95:5 e.r.).
Michele Crotti, Pieter G. Tepper, Thim de Jong, Gerrit J. Poelarends   +3 more
wiley   +1 more source

Recent Advances in Dynamic Kinetic Resolution by Chiral Bifunctional (Thio)urea- and Squaramide-Based Organocatalysts

Molecules, 2016
The organocatalysis-based dynamic kinetic resolution (DKR) process has proved to be a powerful strategy for the construction of chiral compounds. In this feature review, we summarized recent progress on the DKR process, which was promoted by chiral ...
Pan Li, Xinquan Hu, Xiu-Qin Dong, Xumu Zhang   +3 more
doaj   +1 more source

A One-Pot Tandem Strategy in Catalytic Asymmetric Vinylogous Aldol Reaction of Homoallylic Alcohols

Molecules, 2016
Reported is a rationally-designed one-pot sequential strategy that allows homoallylic alcohols to be employed in a catalytic, asymmetric, direct vinylogous aldol reaction with a series of activated acyclic ketones, including trifluoromethyl ketones, γ ...
Xufeng Hou, Zhenzhong Jing, Xiangbin Bai, Zhiyong Jiang   +3 more
doaj   +1 more source

Recent advances in organocatalytic atroposelective reactions

Beilstein Journal of Organic Chemistry
Axial chirality is present in a variety of naturally occurring compounds, and is becoming increasingly relevant also in medicine. Many axially chiral compounds are important as catalysts in asymmetric catalysis or have chiroptical properties. This review
Henrich Szabados, Radovan Šebesta
doaj   +1 more source

Highly Efficient Organocatalytic House‐Meinwald Rearrangement for the Facile Synthesis of Aldehydes: Swift Access to Ibuprofen

Chemistry – A European Journal, Volume 32, Issue 2, 9 January 2026.
We use readily available epoxides and 0.5 mol% bis(trifluoromethane)sulfonimide (Tf2N) as a catalyst to synthesize a broad range of aldehydes in yields ranging from 89% to 97%. Furthermore, we identified aldehyde dimerization intermediates at lower temperatures and observed their cleavage at 55 °C.
Friedemann Dressler, Ihssane El Fdali, Luisa L. Ciezarek, Peter R. Schreiner   +3 more
wiley   +1 more source

Advances in Organic and Organic-Inorganic Hybrid Polymeric Supports for Catalytic Applications

Molecules, 2016
In this review, the most recent advances (2014–2016) on the synthesis of new polymer-supported catalysts are reported, focusing the attention on the synthetic strategies developed for their preparation.
Anna Maria Pia Salvo, Francesco Giacalone, Michelangelo Gruttadauria   +2 more
doaj   +1 more source