Results 11 to 20 of about 456,445 (341)

7-Cyano-15-methoxy[6]helicene through a photochemical pathway and investigation of its chiroptical and photophysical properties

Comptes Rendus. Chimie, 2021
7-Cyano-15-methoxy[6]helicene was synthesized, in 54% overall yield, through a short photochemical procedure including mild conditions and inexpensive reagents.
Hafedh, Nesrine, Asghar, Basim H., Aloui, Faouzi   +2 more
doaj   +1 more source

Enantioselective Synthesis of 5-epi-Citreoviral Using Ruthenium-Catalyzed Asymmetric Ring-Closing Metathesis [PDF]

, 2009
Chiral ruthenium olefin metathesis catalysts can perform asymmetric ring-closing reactions in ≥90% ee with low catalyst loadings. To illustrate the practicality of these reactions and the products they form, an enantioselective total synthesis of 5-epi ...
Funk, Timothy W.
core   +2 more sources

2,4-Bis(arylethynyl)-9-chloro-5,6,7,8-tetrahydroacridines: synthesis and photophysical properties

Beilstein Journal of Organic Chemistry, 2021
Acridine derivatives have attracted considerable interest in numerous areas owing to their attractive physical and chemical properties. Herein, starting from readily available anthranilic acid, an efficient synthesis of 2,4-bis(arylethynyl)-9-chloro-5,6 ...
Najeh Tka, Mohamed Adnene Hadj Ayed, Mourad Ben Braiek, Mahjoub Jabli, Noureddine Chaaben, Kamel Alimi, Stefan Jopp, Peter Langer   +7 more
doaj   +1 more source

Towards energetically viable asymmetric deprotonations : selectivity at more elevated temperatures with C2-symmetric magnesium bisamides [PDF]

, 2011
A novel chiral magnesium bisamide has enabled the development of effective asymmetric deprotonation protocols at substantially more elevated temperatures.
Aggarwal, Alexakis, Allan, Allan J. B. Watson, Anderson, Aoki, Aoki, Aoki, Aoki, Bassindale, Blümke, Brownbridge, Brownbridge, Bunn, Bunn, Bunn, Busch-Petersen, Carswell, Clegg, Conway, Corey, Cousins, Eaton, Eaton, Graf, Graf, Gronnow, Hama, Henderson, Henderson, Henderson, Henderson, Henderson, Hodgson, Ila, Kerr, Kerr, Kerr, Knochel, Leitner, Linsey S. Bennie, Melzig, Michael Middleditch, Mulvey, Navarro, Netherton, Sato, Shirai, Shirai, Simpkins, Simpkins, Westerhausen, William J. Kerr, Wunderlich, Çalimsiz   +54 more
core   +1 more source

Synthesis method of asymmetric gold particles. [PDF]

, 2017
Asymmetric particles can exhibit unique properties. However, reported synthesis methods for asymmetric particles hinder their application because these methods have a limited scale and lack the ability to afford particles of varied shapes.
Hahm, Eunil, Jun, Bong-Hyun, Lee, Luke, Murata, Michael   +3 more
core   +1 more source

Chemical asymmetric synthesis

Nature, 1989
Thalidomide comes in two forms: a left-handed compound which is a powerful tranquilizer, and a right-handed version which can disrupt fetal development causing severe handicap. As a necessary consequence of synthetic methods available in the early 1960s the two forms were present in equal proportions in the manufactured drug, with catastrophic ...
Brown, J, Davies, S
openaire   +2 more sources

Continuous-Flow Synthesis of the Nucleobase Unit of Remdesivir

Engineering, 2023
In this work, the nucleobase unit of the antiviral drug remdesivir, 7-bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, was synthesized through five-step continuous flow.
Yongxing Guo, Minjie Liu, Meifen Jiang, Yuan Tao, Dang Cheng, Fen-Er Chen   +5 more
doaj   +1 more source

Transition metal-catalyzed branch-selective hydroformylation of olefins in organic synthesis

Green Synthesis and Catalysis, 2021
Hydroformylation of olefins can generate linear and branched aldehydes, and the branched aldehydes are attractive precursors for the synthesis of fine chemicals and pharmaceuticals.
Yingtang Ning, Tomohiko Ohwada, Fen-Er Chen   +2 more
doaj   +1 more source

Stereoselective synthesis of hydroxylated 3-aminoazepanes using a multi-bond forming, three-step tandem process [PDF]

, 2012
A multi-bond forming, three-step tandem process involving a palladium(II)-catalysed Overman rearrangement and a ring closing metathesis reaction has been utilised for the efficient synthesis of a 2,3,6,7-tetrahydro-3-amidoazepine.
Ahmad, Ahmad, Anderson, Anderson, Anderson, Andrew Sutherland, Bernstein, Blades, Blanchette, Cant, Cardillo, Chapman, Cini, Cook, Cutri, Cutri, Delmore, Donohoe, Donohoe, Donohoe, Elhalem, Fürstner, Gilmet, Henbest, Horbal, Ireland, Jobson, Jobson, Kantorowski, Kazi, Kulanthaivel, Kurihara, Lampe, Louvel, Maier, Masse, McGonagle, Miyabe, Miyabe, Moriwake, Nicolaou, Nomura, O'Brien, Overman, Pimlott, Riber, Sajjad Ahmad, Sanford, Scholl, Schwab, Schwab, Srivastava, Stevens, Swift, Swift, Tietze, Trost, Valle, Watson, Würdemann, Yar, Yaragorla, Yet, Zaed   +63 more
core   +1 more source

Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability

Acta Pharmaceutica Sinica B, 2023
Our recent studies for nonnucleoside reverse transcriptase inhibitors identified a highly potent compound JK-4b against WT HIV-1 (EC50 = 1.0 nmol/L), but the poor metabolic stability in human liver microsomes (t1/2 = 14.6 min) and insufficient ...
Xin Jin, Shuai Wang, Limin Zhao, Wenjuan Huang, Yinxiang Zhang, Christophe Pannecouque, Erik De Clercq, Ge Meng, Huri Piao, Fener Chen   +9 more
doaj   +1 more source