Results 21 to 30 of about 456,445 (341)
Asymmetric synthesis of (−)-naltrexone
Chemical Science, 2019 The asymmetric synthesis of (−)-naltrexone was achieved by a Rh(i)-catalyzed C–H alkenylation and torquoselective electrocyclization cascade and late-stage C–H hydroxylation.
Sun Dongbang +2 more
openaire +3 more sources
In Vivo Nanodetoxication for Acute Uranium Exposure
Molecules, 2015 Accidental exposure to uranium is a matter of concern, as U(VI) is nephrotoxic in both human and animal models, and its toxicity is associated to chemical toxicity instead of radioactivity. We synthesized different PAMAM G4 and G5 derivatives in order to
Luis Guzmán +4 more
doaj +1 more source
Making Asymmetric Dark Matter Gold: Early Universe Synthesis of Nuggets [PDF]
, 2017 We compute the mass function of bound states of Asymmetric Dark Matter--nuggets--synthesized in the early Universe. We apply our results for the nugget density and binding energy computed from a nuclear model to obtain analytic estimates of the typical ...
Gresham, Moira I. +2 more
core +3 more sources
Molecules, 2015 Volatile phenols, such as 4-ethyphenol (4-EP) and 4-ethylguaiacol (4-EG), are responsible for the “Brett character” found in wines contaminated with Brettanomyces yeast (i.e., barnyard, animal, spicy and smoky aromas).
Verónica Carrasco-Sánchez +4 more
doaj +1 more source
Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability
Acta Pharmaceutica Sinica B, 2023 Considering the undesirable metabolic stability of our recently identified NNRTI 5 (t1/2 = 96 min) in human liver microsomes, we directed our efforts to improve its metabolic stability by introducing a new favorable hydroxymethyl side chain to the C-5 ...
Ya-Li Sang +4 more
doaj +1 more source
Asymmetric Hydrogenation in Water by a Rhodium Complex of Sulfonated 2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl (binap) [PDF]
, 1993 The synthesis of sulfonated 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (binap) is reported; a rhodium complex of this ligand is the first to perform asymmetric hydrogenation in neat water with optical yields as high as those obtained in nonaqueous ...
Davis, Mark E., Wan, Kam-to
core +1 more source
Synthesis of Solution-Phase Phosphoramidite and Phosphite Ligand Libraries and Their In Situ Screening in the Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids [PDF]
, 2007 Herein, we report the automated parallel synthesis of solution-phase libraries of phosphoramidite ligands for the development of enantioselective catalysts.
Feringa, Ben L., +5 more
core +1 more source
Acta Pharmaceutica Sinica B, 2023 Following on our recently developed biphenyl-ATDP non-nucleoside reverse transcriptase inhibitor ZLM-66 (SI = 2019.80, S = 1.9 μg/mL), a series of novel heterocycle-substituted ATDP derivatives with significantly improved selectivity and solubility were ...
Li-Min Zhao +4 more
doaj +1 more source
Catalytic asymmetric synthesis of the alkaloid (+)-myrtine [PDF]
, 2008 A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation–substitution sequence; an efficient
Adriaan J. Minnaard +62 more
core +1 more source