Results 51 to 60 of about 456,445 (341)
A catalytic asymmetric total synthesis of (-)-perophoramidine [PDF]
, 2014 We report a catalytic asymmetric total synthesis of the ascidian natural product perophoramidine. The synthesis employs a molybdenum-catalyzed asymmetric allylic alkylation of an oxindole nucleophile and a monosubstituted allylic electrophile as a key ...
Krüger, Sebastian +3 more
core +3 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Molecular docking investigation of cytotoxic phenanthrene derivatives
Comptes Rendus. Chimie, 2020 Our previous experimental work indicated that the presence of ester functionality in phenanthrene derivatives D-1 and D-2 leads to potent cytotoxicity against the Caco-2 cell line. The present work is based on th-is experimental result.
Guédouar, Habiba +3 more
doaj +1 more source
Molecules, 2023 Sharpless asymmetric dihydroxylation is an important reaction in the enantioselective synthesis of chiral vicinal diols that involves the treatment of alkene with osmium tetroxide along with optically active quinine ligand.
Aqsa Mushtaq +8 more
doaj +1 more source
Proton-Electron Hyperfine Coupling Constants of the Chlorophyll a Cation Radical by ENDOR Spectroscopy [PDF]
, 1977 In this paper we describe the assignment of the major coupling constants in monomer chlorophyll a cation free radical by ENDOR spectroscopy. To facilitate chemical manipulation methylpyrochlorophyllide a has been used as a stand-in, and a suite of six ...
Katz, J. J., Norris, J. R., Scheer, Hugo
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Chiral Modification of the Tetrakis(pentafluorophenyl)borate Anion with Myrtanyl Groups [PDF]
, 2019 The synthesis and characterization of chiral [B(C6F5)4]– derivatives bearing a myrtanyl group instead of a fluoro substituent in the para position are described.
Oestreich, Martin, Pommerening, Phillip
core +1 more source
Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria [PDF]
, 2020 The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist ...
Fullam, Elizabeth +4 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Aggregation-Induced Synthesis (AIS): Asymmetric Synthesis via Chiral Aggregates
Research, 2022 A new chiral aggregate-based tool for asymmetric synthesis has been developed by taking advantage of chiral aggregates of GAP (Group-Assisted Purification) reagents, N-phosphonyl imines.
Hossein Rouh +11 more
doaj +1 more source