Results 111 to 120 of about 36,768 (197)

Disrupted TGF-β signaling: a link between bronchopulmonary dysplasia and alveolar type 1 cells

The Journal of Clinical Investigation
Bronchopulmonary dysplasia (BPD) is a chronic lung disease common in extreme preterm infants and is characterized by alveolar simplification. Current BPD research mainly focuses on alveolar type 2 (AT2) cells, myofibroblasts, and the endothelium. However,
Rongbo Li
doaj   +1 more source

Conserved and Tissue‐Specific RNA and Protein Cargos of Small Extracellular Vesicles From 120 Tissue Sites Across 34 Organs in a Single Pig

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
A whole‐body map of sEVs from a single pig, including 133 samples spanning 10 systems, revealed striking tissue‐specific heterogeneity in yield. Importantly, a conserved core cargo set comprising candidate sEV markers (ACTG1, CFL1, and ANXA2), RNA‐binding proteins, the let‐7 miRNA family, and ferritin genes was defined from 105,409 (88.6% full‐length ...
Naixiang Yu, Jinxiu Liu, Chenliang Lai, Siyi Liu, Jiacheng Wei, Jiahong Zhong, Sanya Xiong, Qingjie Zeng, Junwu Ma, Zhou Zhang, Zhiyan Zhang   +10 more
wiley   +1 more source

Activating autoantibodies against the AT1-receptor in vascular disease

, 2012
Activating autoantibodies to the angiotensin II type I receptor (AT1-AA) have been described in different vascular diseases: preeclampsia, non HLA-mediated transplantat rejection and systemic sclerosis.
Dragun, D., Riemekasten, G., Schulze-Forster, K., Mueller, D.N., Herse, F., Dechend, R., Heidecke, H.   +6 more
core  

The CRABP2–MDK Signaling Axis Promotes Lung Adenocarcinoma (LUAD) Progression and Highlights Prognostic Biomarkers

Molecular Carcinogenesis, Volume 65, Issue 10, Page 1163-1182, October 2026.
ABSTRACT Lung cancer is the leading cause of cancer‐related mortality worldwide, with LUAD being characterized by high incidence and mortality rates. Despite the use of various treatments, including surgery, chemotherapy, immunotherapy, and molecular targeted therapy, the prognosis in LUAD patients remains unfavorable.
Jingshun Zhang, Cui Zhang, Guopeng Jiang, Xia Liu, Yifan Li, Fuman Wang, Xuefei Sun, Peidao Sun   +7 more
wiley   +1 more source

AT1 Instruments After Credit Suisse

This contribution evaluates the effectiveness of AT1 bonds in fulfilling their intended functions, with a particular focus on their role in mitigating systemic risk and absorbing losses on a going-concern basis.
Liegeois, Fabien
core   +1 more source

Triggering AHR resolves TGF-β1 induced fibroblast activation and promotes AT1 cell regeneration in alveolar organoids

Communications Biology
Regeneration of the alveolar epithelium is necessary to restore tissue architecture and gas exchange capabilities in chronic pulmonary diseases such as fibrosing interstitial lung disease.
Andrew S. Hagan, Scott Williams, Casey J. N. Mathison, Shanshan Yan, Bao Nguyen, Glenn C. Federe, Guray Kuzu, Joseph C. Siefert, Janice Hampton, Victor Chichkov, S. Whitney Barnes, Frederick J. King, Brandon L. Taylor, John R. Walker, Rui Zhao, Jimmy Elliott, Dean P. Phillips, Bin Fang, Rebekah S. Decker   +18 more
doaj   +1 more source

Protocol for preparation of primary alveolar epithelial type I cells from mouse lungs

STAR Protocols
Summary: Currently, the only approach for obtaining alveolar epithelial type I (AT1) cells is through the differentiation of cultured AT2 cells, which has several limitations. Here, we present a protocol to prepare AT1 cells directly from mouse lungs. We
Lulu Huang, Amy Tang, Bojing Shao
doaj   +1 more source

Alveolar Macrophages: Development, Respiratory Homeostasis, Signal Pathways, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang, Ruomeng Li, Chuanjiang Yu, Jing Li, Xikun Zhou   +4 more
wiley   +1 more source

Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments

MedComm, Volume 7, Issue 10, October 2026.
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma, Xiaoxuan Zhang, Pujun Zhao, Jiaxin Yang, Zhihao Li, Xiaoyang Han, Yixuan Wang, Zhenzhen Cui, Nian Liu, Min Li   +9 more
wiley   +1 more source

Role and mechanism of AT1-AA in the pathogenesis of HELLP syndrome

, 2018
HELLP syndrome remains a leading cause of maternal and neonatal mortality and morbidity worldwide, which symptoms include hemolysis, elevated liver enzymes and low platelet count.
Shurui Bu, Yuxian Wang, Yanqian Zheng, Shuqing Sun, Jianming Zhi, Zhu Jin   +5 more
core   +1 more source