Results 101 to 110 of about 36,768 (197)

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson, Nikolai B. Nordsborg   +1 more
wiley   +1 more source

Non-HLA angiotensin-type-1 receptor autoantibodies mediate the long-term loss of grafted neurons in Parkinson’s disease models

Stem Cell Research & Therapy
Background Clinical trials have provided evidence that transplants of dopaminergic precursors, which may be replaced by new in vitro stem cell sources, can integrate into the host tissue, and alleviate motor symptoms in Parkinson´s disease (PD).
Ana I. Rodríguez-Pérez, Pablo Garrido-Gil, Maria García-Garrote, Ana Muñoz, Juan A. Parga, Jose Luis Labandeira-García, Jannette Rodríguez-Pallares   +6 more
doaj   +1 more source

Design‐Assisted Chemometric UV Spectrophotometric Determination of Candesartan Cilexetil, Chlorthalidone and Amlodipine Using Principal Component Regression, Partial Least Squares and Genetic Algorithm‐Partial Least Squares Models

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT This study presents a sustainable chemometric‐assisted UV spectrophotometric strategy for the simultaneous determination of candesartan cilexetil (CAN), chlorthalidone (CTL) and amlodipine (AML) in laboratory‐prepared mixtures and commercial pharmaceutical formulations.
Khanda F. M. Amin, Samar H. Elagamy, Reem H. Obaydo, Hayam M. Lotfy   +3 more
wiley   +1 more source

A Stable Formulation for Wave‐Induced Fracture in Peridynamics

Proceedings in Applied Mathematics and Mechanics, Volume 26, Issue 4, December 2026.
ABSTRACT The bond‐associated quadrature point formulation is a very accurate peridynamic formulation for elasticity, but modeling fracture by the traditional deletion of bonds can trigger severe numerical instabilities. These instabilities are most pronounced for wave‐induced fracture, where stress waves continue to propagate through already damaged ...
Kai Partmann, Manuel Dienst, Christian Wieners, Kerstin Weinberg   +3 more
wiley   +1 more source

On the Computation of Crack Surface Normals in the Phase‐Field Model of Hydraulic Fracture

Proceedings in Applied Mathematics and Mechanics, Volume 26, Issue 4, December 2026.
ABSTRACT Hydraulic fracturing techniques have been used to extract oil from the Earth's crust and to enhance the efficiency of geothermal systems among other applications. Numerical simulation of hydraulic fracturing is essential for predicting the environmental impact of this method, as well as its efficiency in such applications. In the present work,
Anuj Gupte, Elten Polukhov, Marc‐André Keip   +2 more
wiley   +1 more source

Four Decades of Research at the MADE Site and Beyond: Advancing the Understanding and Modeling of Solute Transport in Heterogeneous Media

Reviews of Geophysics, Volume 64, Issue 4, December 2026.
Abstract Spatial heterogeneity, manifested as strong variability in hydraulic conductivity (K) within geological formations, exerts a fundamental control on groundwater flow and solute transport. Because K can vary over multiple orders of magnitude in complex three‐dimensional patterns, predicting contaminant plume migration remains a long‐standing ...
Zhilin Guo, Maosheng Yin, Peiyao Dong, Yong Zhang, Kewei Chen, Graham Fogg, Brian Berkowitz, Marco Dentz, Chunmiao Zheng   +8 more
wiley   +1 more source

Effect of ang II AT1 receptor antagonists, on periodontal disease induced by injections of lipopolysaccharide in rats.

, 2013
La Enfermedad Periodontal (EP) es una condición inflamatoria progresiva que afecta los tejidos que soportan y rodean a los dientes. Las endotoxinas bacterianas como los lipopolisacáridos (LPS), inducen una cascada inflamatoria causando resorción ósea ...
Matos Uzcategui, Maria Gabriela
core   +1 more source

Fracture Modeling of Nearly Incompressible Hyperelastic Materials: A Phase‐Field Approach via Simo–Taylor–Pister Three‐Field Variation

International Journal for Numerical Methods in Engineering, Volume 127, Issue 19, 15 October 2026.
ABSTRACT Incompressibility is commonly observed in the majority of hyperelastic materials, which are fundamental to a wide range of technical applications owing to their distinctive properties, particularly their flexibility, stretchability, and resilience.
Le Zhang, Bin Li, Dong Zhao, Bo Yin, Michael Kaliske   +4 more
wiley   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source