Results 81 to 90 of about 36,768 (197)

Angiotensin II type 1 receptor blockade partially attenuates hypoxia-induced pulmonary hypertension in newborn piglets: relationship with the nitrergic system

Brazilian Journal of Medical and Biological Research, 2012
The objective of this study was to observe possible interactions between the renin-angiotensin and nitrergic systems in chronic hypoxia-induced pulmonary hypertension in newborn piglets.
J.S. Camelo Jr., A.R. Martins, E. Rosa, S.G. Ramos, D. Hehre, E. Bancalari, C. Suguihara   +6 more
doaj   +2 more sources

Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors.

Folia Histochemica et Cytobiologica, 2008
Angiotensin II is well known to affect the adrenal cell growth and function. Angiotensin receptors AT1 and AT2 were found to be present in the normal adrenal gland.
Marek Pawlikowski, Katarzyna Winczyk, Beata Sledź   +2 more
doaj   +1 more source

Metabolic remodelling in anthracycline cardiotoxicity: mechanisms and therapeutic insights

British Journal of Pharmacology, EarlyView.
Cardiac metabolic remodelling in anthracycline‐induced cardiomyopathy and metabolically oriented cardioprotective strategies. Schematic representation of substrate utilization, mitochondrial bioenergetic function and metabolic flexibility in the healthy heart, in anthracycline‐induced cardiomyopathy and under potential cardioprotective interventions ...
Giulia Guerra, Francesco Niro, Marco Mergiotti, Giovanni Gavatorta, Emilio Hirsch, Alessandra Ghigo   +5 more
wiley   +1 more source

Manifold active-state conformations in GPCRs: Agonist-activated constitutively active mutant AT1 receptor preferentially couples to Gq compared to the wild-type AT1 receptor [PDF]

, 2007
The angiotensin II type I (AT1) receptor mediates regulation of blood pressure and water-electrolyte balance by Ang II. Substitution of Gly for Asn111 of the AT1 receptor constitutively activates the receptor leading to Gq-coupled IP3 production ...
Chung, Hye-Shin, Bhat, Manjunatha B., Karnik, Sadashiva S., Hwang, Si Ae, Lee, ChangWoo, Jang, Sei-Heon   +5 more
core   +1 more source

Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

British Journal of Pharmacology, EarlyView.
Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan, Rwdah Mohamed Alameri, Yasir S. Raouf, Damien Maurel, Naiem Ahmad Wani, Anatoliy Shmygol, Irfa Anwar, Heng B. See, Elizabeth K. M. Johnstone, Elodie Dupuis, Eric Trinquet, Kevin D. G. Pfleger, Emilia Oueis, Mohammed Akli Ayoub   +13 more
wiley   +1 more source

Angiotensin-II Actions and AT1-Receptors During Statin Withdrawal.

, 2008
Background. Acute discontinuation of statins induces vascular dysfunction and increases cardiovascular events. The mechanisms underlying these events are under investigation.
Castejon, Ana Maria, Zollner, Emily, Tristano, Antonio G, Cubeddu, Luigi X   +3 more
core   +1 more source

Vasopressor meets vasodepressor: The AT1-B2 receptor heterodimer [PDF]

, 2014
The AT1 receptor for the vasopressor angiotensin II is one of the most important drug targets for the treatment of cardiovascular diseases. Sensitization of the AT1 receptor system is a common feature contributing to the pathogenesis of many ...
AbdAlla, Said, Quitterer, Ursula
core   +1 more source

Blockade of Angiotensin II Receptor Type 1 Abolishes the Erythropoietin Response to Exercise

Function
Beneficial adaptations to exercise depend on the normal function of the endocrine system. Whether commonly prescribed antihypertensive medication inhibits erythropoietin (EPO) production with exercise, a key response to enhance aerobic capacity, remains ...
Meihan Guo, David Montero
doaj   +1 more source

Human Embryonic Stem Cell‐Derived Immunity‐And‐Matrix‐Regulatory Cells Attenuate Pulmonary Fibrosis via MMP1‐Mediated Collagen Degradation

Cell Proliferation, EarlyView.
Human embryonic stem cell‐derived Immunity‐and‐Matrix‐Regulatory Cells (IMRCs) effectively attenuate pulmonary fibrosis by secreting Matrix Metalloproteinase‐1 (MMP1), which directly degrades excess collagen I in the extracellular matrix. By directly degrading collagen I, IMRCs reverse ECM stiffness, suppress myofibroblast activation, and promote a ...
Zhongwen Li, Dingyun Song, Faguo Sun, Licheng Song, Bin An, Tingting Gao, Jingjing Liu, Kan Zhang, Kaidi Liu, Kaiwei Wu, Yajing Li, Yi Yang, Yaru Liu, Ruofan Su, Zai Wang, Tiemei Zhao, Huaiyong Chen, Li Xiao, Liang Peng, Liu Wang, Wei Li, Lixin Xie, Jie Hao, Huaping Dai, Jun Wu   +24 more
wiley   +1 more source

Human iPSC‐Derived Vascularised Lung Organoids for Modelling COPD and Pulmonary Hypertension

Cell Proliferation, EarlyView.
Vascularised lung organoids (vLOs) that faithfully mimic human lung tissue architecture and disease pathology are critical for advancing pulmonary research but remain challenging to generate. Here, we developed a robust self‐organisation protocol to produce vLOs with cellular heterogeneity and functional vasculature. The engineered blood vessels within
Simin Jiang, Liangliang Tian, Jingge Qu, Yi Hong, Dian Chen, Zihang Pan, Huanyu Long, Lanhe Chu, Weijing Kong, Qiyang Yao, Xiaojing Ma, Yun Zhao, Baihui Ma, Kai Wang, Yahong Chen   +14 more
wiley   +1 more source