Results 71 to 80 of about 36,768 (197)

Fitting in and feeling good: Reciprocal associations between peer acceptance and emotions in the classroom

British Journal of Educational Psychology, EarlyView.
Abstract Background According to the control‐value theory of achievement emotions, the classroom social environment is an important antecedent of children's emotions, with emotions, in turn, influencing this environment. We focus on a in CVT largely neglected but important aspect of CVT that has been largely neglected: peer relationships.
Tim Mainhard, Elisabeth Graf, Minke A. Krijnen, Lian Van Vemde, Bjorn G. J. Wansink, Thomas Goetz   +5 more
wiley   +1 more source

Angiotensin II Type I Receptor Agonistic Autoantibody Induces Podocyte Injury via Activation of the TRPC6- Calcium/Calcineurin Pathway in Pre-Eclampsia

Kidney & Blood Pressure Research, 2018
Background/Aims: Angiotensin II type I receptor agonistic autoantibody (AT1-AA) is closely related to pre-eclampsia, which is characterized by proteinuria and hypertension.
Ying Yu, Lihong Zhang, Guang Xu, Zhenghong Wu, Qian Li, Yong Gu, Jianying Niu   +6 more
doaj   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Models for AT1, AT2, and MAS.

, 2016
A) Methodology for creating models of AT1, AT2 and MAS beginning with I-TASSER models, adding cysteine bridges, inserting into a lipid membrane and then running molecular dynamics simulations. B) The averaged models from A for AT1, AT2, and MAS.
Amy Milsted (30880), Robson A. S. Santos (384592), Jeremy W. Prokop (417645)   +2 more
core   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats [PDF]

, 2018
Obesity is associated with the inappropriate activation of the renin-angiotensin system (RAS), which increases arterial pressure, impairs insulin secretion and decreases peripheral tissue insulin sensitivity.
Nakano, Daisuke, Rudy M Ortiz, Minas, Jacqueline N, Jacqueline N Minas, Vazquez-Medina, Jose Pablo, Ortiz, Rudy M, Rodriguez, Ruben, Jose Pablo Vazquez-Medina, Akira Nishiyama, Daisuke Nakano, David G Parkes, Nishiyama, Akira, Ruben Rodriguez, Parkes, David G   +13 more
core   +1 more source

Angiotensin AT1 Receptor Blockade Protects the Brain from Ischemic Damage [PDF]

, 2007
Angiotensin (Ang) AT1 receptors are considered to play an important role in ischemic stroke via degenerative processes leading to cell death. Recent clinical and basic studies show that systemic blockade of Ang AT1 receptors reduces brain lesion in ...
Penchikala, Madhuri
core   +2 more sources

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

Alamandine/MrgD pathway modulates gut–bone marrow axis in ageing

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ageing is associated with colon epithelial barrier disruption and up‐regulation of myelopoiesis in the bone marrow (BM). Alamandine (Ala) and MrgD are novel members of the renin angiotensin system (RAS). This study tested the hypothesis that Ala restores the colon epithelial barrier integrity in ageing via modulating gut–
Kishore Chittimalli, Henryata E. Rozario, Victor Martinez, Zachary L. McAdams, Stephen A. Adkins, Aaron C. Ericsson, Yagna P. R. Jarajapu   +6 more
wiley   +1 more source