Results 181 to 190 of about 176,761 (289)

Epigenetics in cancer: from mechanisms to precision medicine

Molecular Oncology, Volume 20, Issue 10, Page 2389-2392, October 2026.
Reversible epigenetic programs, including DNA methylation, chromatin modifications, and chromatin architecture, shape dynamic tumor states. Spatial and single‐cell profiling identify tumor plasticity, evolution, and immune evasion, enabling biomarker‐guided precision medicine and rational epigenetic combinations to expose therapeutic vulnerabilities ...
Sung Hee Baek
wiley   +1 more source

Epistatic chromatin remodeling during barley response to powdery mildew by ATAC-Seq. [PDF]

Sci Data
Velásquez-Zapata V, Smith SD, Fuerst G, Wise RP.   +3 more
europepmc   +1 more source

ATAC-seq Protocol for Arthropods

Here we provide a step-by-step protocol for the generation of ATAC-seq libraries for emerging arthropod model systems. The protocol contains additional information about preservation methods addressed in the article "ATAC-seq in Emerging Model Organisms:
Posnien, Nico, Turetzek, Natascha, Erdoğan, Duğçar Ebrar, Feldmeyer, Barbara   +3 more
core   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Beyond chromatin accessibility: bulk ATAC-seq as an integrative assay to portray genomes and epigenomes. [PDF]

NAR Genom Bioinform
Toumi I, Kham C, Stuani L, Le Cam L, Roux PF.   +4 more
europepmc   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, Volume 13, Issue 55, 5 October 2026.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

scATAnno: Automated Cell Type Annotation for Single-cell ATAC-seq Data. [PDF]

Genomics Proteomics Bioinformatics
Jiang Y, Hu Z, Lu F, Lynch AW, Jiang J, Zhu A, Zeng Z, Zhang Y, Wu G, Xie Y, Li R, Zhou N, Meyer CA, Cejas P, Brown M, Long HW, Qiu X.   +16 more
europepmc   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, Volume 13, Issue 57, 14 October 2026.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Integrated ATAC-Seq and RNA-Seq Identify ATF3 as a Tumor Suppressor in UVB-Induced Keratinocyte Carcinogenesis. [PDF]

Biology (Basel)
Guo Z, Deng X, Lu S, Liu F, Zhou M, Wang Y.   +5 more
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, Volume 13, Issue 57, 14 October 2026.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source