Results 201 to 210 of about 176,761 (289)

Gene therapy for hereditary deafness: Progress, challenges and translational implications from OTOF to GJB2

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Current Management & Limitations: Traditional auditory devices lack genetic curative potential and yield variable, non‐physiological hearing outcomes. OTOF gene therapy has shown promising clinical outcomes with dual‐AAV therapy. GJB2 gene therapy remains an emerging approach with significant translational challenges. Advances in vector design and cell‐
Jiahui Zhao, Mengzhao Xun, Yu Sun
wiley   +1 more source

Integration of ATAC-seq and RNA-seq profiling reveals an epigenetic regulator of anthocyanin synthesis in Prunus mume. [PDF]

BMC Plant Biol
Tang Y, Wang M, Li P, Li B, Zhang Q.
europepmc   +1 more source

Single‐cell multi‐omics characterises transcriptional and chromatin accessibility heterogeneity of immune cells in allergic rhinitis

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Key Points 1. SAR and PAR showed distinct immune landscapes. 2. Macro_CCL3 showed phenotype‐specific inflammatory and antigen‐presentation features. 3. CD8_Trm displayed subtype‐associated chromatin accessibility linked to cytotoxicity‐related signatures. 4.
Yisha Wu, Zhihan Xu, Shikai Han, Zhongzhen Liu, Rui Dong, Chuanyu Liu, Jianhua Yin, Jinmei Xue   +7 more
wiley   +1 more source

S-Methylmethionine Attenuates Aflatoxin B1-Induced Mammary Epithelial Injury: Functional Assessment and Exploratory ATAC-Seq/RNA-Seq Analysis. [PDF]

Toxins (Basel)
Huang J, Ling C, Li Y, Wang Y, Yang L, Xu Q, Deng H, Li C.   +7 more
europepmc   +1 more source

Spatiotemporal transcriptomics for tumour microenvironment remodelling in cancer progression and therapy

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review summarises how spatial transcriptomics technologies reveal tumour microenvironment heterogeneity and support the inference of dynamic remodelling during cancer progression. Abstract Background Spatiotemporal transcriptomics (STT) integrates spatially resolved gene expression with temporal information derived from staged samples, paired ...
Ying Kang, Qinjing Wang, Siqi Xu, Jiming Guo, Yue Ming, Weixing Chen, Min Wang, Zhijie Huang, Yisheng Huang, Bo Jia   +9 more
wiley   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, Volume 11, Issue 5, Page 1395-1412, October 2026.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

Single-nucleus ATAC-seq analysis resolves chromatin and transcriptional features of fibrolamellar carcinoma. [PDF]

Sci Rep
Farghli AR, Sherman MS, Shui B, Stephanou A, Pepe-Mooney BJ, Smith CJ, Long D, Munn PR, McNairn A, Grenier JK, Karski M, Goessling W, Vakili K, Sethupathy P.   +13 more
europepmc   +1 more source

Enhanced IFNy response in dedifferentiated melanoma cells is due to chromatin remodeling as revealed by ATAC-seq. [PDF]

Cell Commun Signal
Sævarsson T, de Lomana ALG, Sánchez Ó, Brynjólfsson SF, Steingrímsson E, Einarsdóttir BÓ.   +5 more
europepmc   +1 more source

HIV‐1 Vpr Drives a B Cell‐Like Phenotype in Primary CD4+ T Cells

MedComm, Volume 7, Issue 10, October 2026.
During acute HIV‐1 infection, Vpr induces transcriptional and epigenetic remodeling of primary CD4+ T cells, activating a transient B cell‐like program characterized by CD19, MS4A1, CD22, and PAX5 expression and increased chromatin accessibility at lymphocyte differentiation genes.
Peipei Wang, Jieying Li, Wei Wang, Zhuoyue Meng, Huixin Wu, Shumin Du, Kai Deng, Jinfeng Cai   +7 more
wiley   +1 more source

ATAC-seq and RNA-seq reveal key genes and pathways regulating lactation in the mammary gland of Yili horses. [PDF]

BMC Genomics
Liu L, Chen B, Kong M, Tian Y, Ma H, Cao H, Liu W.   +6 more
europepmc   +1 more source