Results 191 to 200 of about 176,761 (289)

Robust footprinting with sample-specific Tn5 bias correction for bulk and single cell ATAC-seq. [PDF]

Nat Commun
Lin Y, Wang H, Wilson PC, Zhang NR.
europepmc   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

ATAC-seq of low-input and cryopreserved primordial germ cells reveals functional enhancers. [PDF]

Development
Kawaguchi A, Igari M, Murayama Y, Iikawa H, Sakamoto M, Nakamura Y, Kuraku S, Ishihara K, Saito D.   +8 more
europepmc   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

RAGER: A user-friendly computational platform for integrated analysis of RNA-Seq and ATAC-seq data. [PDF]

PLoS One
Liu Y, Liu Y, Zhang Z, Li F, Yu H, Lu L.
europepmc   +1 more source

Spatiotemporal heterogeneity and dynamic evolution of microglial glucose metabolic reprogramming in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Alzheimer's disease (AD) is accompanied by persistent disturbances in brain energy metabolism, and microglial glucose metabolic reprogramming constitutes an important link among pathological protein deposition, neuroinflammation, and impaired clearance.
Yuan Chen, Fuyao Li, Junlei Zhang, Mingqing Wei, Jingnian Ni, Ting Li, Lulu Yao, Jinzhou Tian, Jing Shi   +8 more
wiley   +1 more source

Integrative WGBS and ATAC-seq profiling reveals epigenetic and chromatin accessibility signatures associated with clutch length in goose ovaries. [PDF]

Poult Sci
Wang H, Yin J, Jiang K, Cong K, Liu Y, Yang W, Miao X, Chen Z, Zhang Y, Liu S.   +9 more
europepmc   +1 more source

Interplay Between Epigenetics and Reactive Oxygen Species in Tumor Radioresistance: Mechanisms and Therapeutic Strategies for Radiotherapy

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Radiotherapy efficacy is constrained by tumor radioresistance, which arises in part from the interplay between reactive oxygen species (ROS) and epigenetic regulation. This review systematically synthesizes the bidirectional “epigenetics‐ROS interactive network” that governs tumor radiosensitivity. We propose that this network operates through
Zhengmao Yang, Jiaxin Wang, Guofang Wang, Jiamin Zhu, Shengnan Zhang, Wenjian Guo   +5 more
wiley   +1 more source

Integrative ATAC-Seq and RNA-Seq analysis identifies key genes for intramuscular fat content in Laiwu pigs. [PDF]

BMC Genomics
Li J, Wang J, Wang Y, Mao R, Zhao X.
europepmc   +1 more source

Alignment-free integration of single-nucleus ATAC-seq across species with sPYce. [PDF]

Nat Ecol Evol
Zeitler L, Berthelot C.
europepmc   +1 more source