Results 211 to 220 of about 176,761 (289)

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source

Clinical Epigenomics in Rare Diseases: Interpreting DNA Methylation Episignatures

Molecular Genetics &Genomic Medicine, Volume 14, Issue 10, October 2026.
Clinical epigenomics extends rare‐disease diagnostics beyond DNA sequence by revealing the downstream regulatory consequences of genetic variation. DNA methylation episignatures provide functional evidence that can support diagnosis, refine variant interpretation, distinguish overlapping disorders, and complement genomic, and multi‐omic testing ...
Himanshu Goel, Shuxiang Goh, Luke Stuart
wiley   +1 more source

Integrated RNA-seq and ATAC-seq analyses reveal muscle development differences between european meat pigeon and shiqi pigeon during embryonic to post-hatching stages. [PDF]

Front Cell Dev Biol
Han Y, Hong P, Liu Z, Chen T, Chang K, Chen W, Zhong Y, Qiu Z, Zheng Z, Li X, Wu Z, Liang Y, Zhang X.   +12 more
europepmc   +1 more source

Advancing clinical precision medicine via peripheral blood immune single‐cell omics

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Liyang Li, Jialu Hu, Wanxin Duan, Yan‐Ming Xu, Jiaqiang Zhang, Xiangdong Wang   +5 more
wiley   +1 more source

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine

Aging Cell, Volume 25, Issue 10, October 2026.
Our studies for the first time underscore the feasibility of long‐term SIRT6 activation as a pharmacological strategy to maintain the health of the intervertebral disc in the aging spine. ABSTRACT Aging is a critical risk factor for intervertebral disc degeneration, a major contributor to chronic low back pain.
Pranay Ramteke, Bahiyah Watson, Sanjana Jagannath, Sarah E. Bell, Mallory Toci, Olivia Ottone, Qinglin Wu, Oliver Abinader, Ramkrishna Mitra, John A. Collins, Ruteja A. Barve, Makarand V. Risbud   +11 more
wiley   +1 more source

Integrated ATAC-seq and mRNA-seq analyses on granulosa cells identify key regulators of follicle selection in chickens. [PDF]

J Anim Sci Biotechnol
Li D, Qi C, Sun Y, Kang L, Wei Q, Jiang Y.   +5 more
europepmc   +1 more source

ZNF865 (BLST) a Novel Regulator of DNA Damage and Cell Senescence in Back Pain

Aging Cell, Volume 25, Issue 10, October 2026.
ZNF865 (BLST) has previously been classified as part of the “unknome”, but here in the context of back pain, we demonstrate the first functional characterization of ZNF865. We demonstrate that it regulates genomic stability and subsequent senescence, and that downregulation in the intervertebral disc leads to pain behavior in rodent models.
Christian Lewis, Hunter Levis, Jonah Holbrook, Jacob T. Polaski, Timothy D. Jacobsen, Josh Mizels, Molly Czachor, Sarah E. Gullbrand, Brian Diekman, James C. Iatridis, Jason Gertz, Brandon Lawrence, Robby D. Bowles   +12 more
wiley   +1 more source

Developing a comprehensive database and search tool for single-cell ATAC-seq data. [PDF]

Sci Rep
Gibson-Khademi A, Wang J, Christensen E, Shooshtari P.   +3 more
europepmc   +1 more source

Elevated CO2 and Temperature Alter Grass Pollen's Ability to Modify Transcriptome and Function of the Nasal Epithelium

Allergy, Volume 81, Issue 10, Page 3554-3567, October 2026.
We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen, Tanja Turunen, Maria‐Viola Martikainen, Miisa Kankaanpää, Marjo Malinen, Marjut Roponen   +5 more
wiley   +1 more source

Integration of ATAC-seq and RNA-seq unveils transcription factors involved in low-nitrogen tolerance in cucumber. [PDF]

Front Plant Sci
Li B, Ma L, Wu H, Han Y, Liu N, Liu C, Du S, Wei A.   +7 more
europepmc   +1 more source