Targeting ATM pathway for therapeutic intervention in cancer [PDF]
BioDiscovery, 2012 The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Hilal S Khalil +4 more
doaj +8 more sources
Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia
Antioxidants, 2022 The ataxia-telangiectasia mutated (ATM) protein kinase is, as the name implies, mutated in the human genetic disorder ataxia-telangiectasia (A-T). This protein has its “finger in many pies”, being responsible for the phosphorylation of many thousands of ...
Goutham Narayanan Subramanian +4 more
doaj +1 more source
ATM Modulates Nuclear Mechanics by Regulating Lamin A Levels
Frontiers in Cell and Developmental Biology, 2022 Ataxia-telangiectasia mutated (ATM) is one of the three main apical kinases at the crux of DNA damage response and repair in mammalian cells. ATM activates a cascade of downstream effector proteins to regulate DNA repair and cell cycle checkpoints in ...
Pragya Shah +8 more
doaj +1 more source
Sensors and Inhibitors for the Detection of Ataxia Telangiectasia Mutated (ATM) Protein Kinase [PDF]
Molecular Pharmaceutics, 2021 Recruitment and activation of the ataxia telangiectasia mutated (ATM) kinase regulate multiple cell-cycle checkpoints relevant to complex biological events like DNA damage repair and apoptosis. Molecularly specific readouts of ATM using protein assays, fluorescence, or radiolabeling have advanced significantly over the past few years.
Cien Huang +3 more
openaire +2 more sources
MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks.
PLoS ONE, 2022 Ataxia Telangiectasia mutated and RAD3-related (ATR) kinase is activated by DNA replication stress and also by various forms of DNA damage, including DNA double-strand breaks (DSBs).
Katrina Montales +3 more
doaj +1 more source
What Lies in between Telomere and Organismal Ageing: Comparison between Replicative Senescence and Stress-Induced Premature Senescence [PDF]
E3S Web of Conferences, 2021 A mitotic cell that rests in permanent cell cycle arrest without the ability to divide is considered as a senescent cell. Cellular senescence is essential to limit the function of cells with heavy DNA damages.
Jia Hanyi
doaj +1 more source
Immunoassay to Measure Ataxia-Telangiectasia Mutated Protein in Cellular Lysates [PDF]
Clinical Chemistry, 2004 AbstractBackground: Ataxia-telangiectasia (A-T) is a neurologic disorder caused by mutations in the ataxia-telangiectasia mutated (ATM) gene. A clinical diagnosis of A-T is confirmed by radiosensitivity testing and immunoblotting for ATM protein. Because both of these tests have long turnaround times (≥3 months), we developed a rapid immunoassay to ...
Anthony W, Butch +3 more
openaire +2 more sources
Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A [PDF]
The EMBO Journal, 2004 Ionizing radiation induces autophosphorylation of the ataxia-telangiectasia mutated (ATM) protein kinase on serine 1981; however, the precise mechanisms that regulate ATM activation are not fully understood. Here, we show that the protein phosphatase inhibitor okadaic acid (OA) induces autophosphorylation of ATM on serine 1981 in unirradiated cells at ...
Goodarzi, Aaron A +7 more
openaire +3 more sources
Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression. [PDF]
PLoS ONE, 2016 Several stressors are known to influence epithelial tight junction (TJ) integrity, but the association between DNA damage and TJ integrity remains unclear.
Akihiro Watari +3 more
doaj +1 more source
Residual Ataxia Telangiectasia Mutated Protein Function in Cells from Ataxia Telangiectasia Patients, with 5762ins137 and 7271T→G Mutations, Showing a Less Severe Phenotype [PDF]
Journal of Biological Chemistry, 2001 We have assessed several ataxia Telangiectasia mutated (ATM)-dependent functions in cells derived from ataxia telangiectasia patients, carrying either an ATM 5762ins137 splice site or a 7271T-->G missense mutation, with a less severe phenotype compared with the classical disorder.
G S, Stewart +6 more
openaire +2 more sources