Targeting ATM pathway for therapeutic intervention in cancer [PDF]
BioDiscovery, 2012 The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Hilal S Khalil +4 more
doaj +8 more sources
Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellular DSB repair [PDF]
Virology Journal, 2008 Retroviral transduction involves integrase-dependent linkage of viral and host DNA that leaves an intermediate that requires post-integration repair (PIR).
Wu Kou-Juey +5 more
doaj +2 more sources
Cancer Biology & Medicine, 2020 Objective: Mitotic arrest-deficient protein 1 (MAD1) is a kinetochore protein essential for the mitotic spindle checkpoint. Proteomic studies have indicated that MAD1 is a component of the DNA damage response (DDR) pathway.
Mingming Xiao +9 more
doaj +2 more sources
Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia
Antioxidants, 2022 The ataxia-telangiectasia mutated (ATM) protein kinase is, as the name implies, mutated in the human genetic disorder ataxia-telangiectasia (A-T). This protein has its “finger in many pies”, being responsible for the phosphorylation of many thousands of ...
Goutham Narayanan Subramanian +4 more
doaj +1 more source
ATM Modulates Nuclear Mechanics by Regulating Lamin A Levels
Frontiers in Cell and Developmental Biology, 2022 Ataxia-telangiectasia mutated (ATM) is one of the three main apical kinases at the crux of DNA damage response and repair in mammalian cells. ATM activates a cascade of downstream effector proteins to regulate DNA repair and cell cycle checkpoints in ...
Pragya Shah +8 more
doaj +1 more source
What Lies in between Telomere and Organismal Ageing: Comparison between Replicative Senescence and Stress-Induced Premature Senescence [PDF]
E3S Web of Conferences, 2021 A mitotic cell that rests in permanent cell cycle arrest without the ability to divide is considered as a senescent cell. Cellular senescence is essential to limit the function of cells with heavy DNA damages.
Jia Hanyi
doaj +1 more source
MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks.
PLoS ONE, 2022 Ataxia Telangiectasia mutated and RAD3-related (ATR) kinase is activated by DNA replication stress and also by various forms of DNA damage, including DNA double-strand breaks (DSBs).
Katrina Montales +3 more
doaj +1 more source
Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression. [PDF]
PLoS ONE, 2016 Several stressors are known to influence epithelial tight junction (TJ) integrity, but the association between DNA damage and TJ integrity remains unclear.
Akihiro Watari +3 more
doaj +1 more source
Selective human inhibitors of ATR and ATM render Leishmania major promastigotes sensitive to oxidative damage. [PDF]
PLoS ONE, 2018 All cellular processes, including those involved in normal cell metabolism to those responsible for cell proliferation or death, are finely controlled by cell signaling pathways, whose core proteins constitute the family of phosphatidylinositol 3-kinase ...
Raíssa Bernardes da Silva +3 more
doaj +1 more source
ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot. [PDF]
PLoS ONE, 2010 Chromosome translocations induced by DNA damaging agents, such as ionizing radiation and certain chemotherapies, alter genetic information resulting in malignant transformation. Abrogation or loss of the ataxia-telangiectasia mutated (ATM) protein, a DNA
Jiying Sun +10 more
doaj +1 more source