Results 221 to 230 of about 40,878 (239)

Hydroxycarbamide and Sickle Cell Anemia: Paradoxical Effects Related to Redox Mechanisms of Cellular Adaptation. [PDF]

ACS Omega
Santana ILR, Bernardo VS, Belini Junior E, da Silva PLP, da Silva DGH, Venancio LPR.   +5 more
europepmc   +1 more source

E7386 Enhances Lenvatinib's Antitumor Activity in Preclinical Models and Human Hepatocellular Carcinoma. [PDF]

Clin Cancer Res
Mesropian A, Gris-Oliver A, Balaseviciute U, Potdar AA, Kimura T, Shen J, Torres-Marcén M, Abril-Fornaguera J, Piqué-Gili M, Camell-Raventos D, Peix J, Fernández-Martínez E, Huguet-Pradell J, Hernández de Sande A, Keraite I, Esteban-Fabró R, Bárcena-Varela M, Lindblad KE, Lujambio A, Guccione E, Thung S, Ikeda M, Kudo M, Sia D, Pinyol R, Llovet JM.   +25 more
europepmc   +1 more source

The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications. [PDF]

Front Mol Biosci
Schröder E, Jalilvand TV, Kahl J, Kaiser CS, Liebau E.   +4 more
europepmc   +1 more source

PARP inhibitor BMN673 triggers PARylation-mediated ATF4-GDF15 pathway to drive autophagy and ferroptosis in ataxia telangiectasia mutated gene-deficient colorectal cancer cells. [PDF]

Mol Biomed
Xiang J, Xu J, Fan H, Chen Q, Lu Y, Wan X, Jiang Y, Zhang X, Zhang C, Liu Q, Ding D, Lei Y.   +11 more
europepmc   +1 more source

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TGFBR3 supports anoikis through suppressing ATF4 signaling

Journal of Cell Science, 2022
ABSTRACT Epithelial morphogenesis and oncogenic transformation can cause loss of cell adhesion, and detached cells are eliminated by anoikis. Here, we reveal that transforming growth factor β receptor 3 (TGFBR3) acts as an anoikis mediator through the coordination of activating transcription factor 4 (ATF4).
Yu-Jhen Hsu, Yih-Jia Yin, Kai-Feng Tsai, Cian-Chun Jian, Zi-Wen Liang, Chien-Yu Hsu, Chun-Chao Wang   +6 more
openaire   +2 more sources

Endoplasmic reticulum stress increases LECT2 expression via ATF4

Biochemical and Biophysical Research Communications, 2021
Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity, insulin resistance, and endoplasmic reticulum (ER) stress. Elevated circulating levels of the hepatokine leukocyte cell-derived chemotaxin-2 (LECT2) have also been noted in NAFLD; however, the mechanism underlying this association is unclear. To investigate a possible link
Chan Yoon Park, Seul Ki Lee, Jimin Kim, Donguk Kim, Han Choe, Ji-Hoon Jeong, Kyung-Chul Choi, Hye Soon Park, Sung Nim Han, Yeon Jin Jang   +9 more
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Probabilistic models of uORF-mediated ATF4 translation control

Mathematical Biosciences, 2022
ATF4 is a key transcription factor that activates transcription of genes needed to respond to cellular stress. Although the mRNA encoding ATF4 is present at constant levels in the cell during the initial response, translation of ATF4 increases under conditions of cellular stress while the global translation rate decreases.
Olivia N.J.M. Marasco, Marc R. Roussel, Nehal Thakor   +2 more
openaire   +2 more sources

Role of ATF4 in skeletal muscle atrophy

Current Opinion in Clinical Nutrition & Metabolic Care, 2017
Here, we discuss recent work focused on the role of activating transcription factor 4 (ATF4) in skeletal muscle atrophy.Muscle atrophy involves and requires widespread changes in skeletal muscle gene expression; however, the transcriptional regulatory proteins responsible for those changes are not yet well defined. Recent work indicates that some forms
Christopher M, Adams, Scott M, Ebert, Michael C, Dyle   +2 more
openaire   +2 more sources