Results 1 to 10 of about 29,072 (277)

A lifetime of stress: ATF6 in development and homeostasis [PDF]

Journal of Biomedical Science, 2018
Background Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors.
Robert F. Hillary, Una FitzGerald
doaj   +6 more sources

Roles and Clinical Significances of ATF6, EMC6, and APAF1 in Prognosis of Pancreatic Cancer [PDF]

Frontiers in Genetics, 2022
Background: Pancreatic cancer (PC) is prevalent among malignant tumors with poor prognosis and lacks efficient therapeutic strategies. Endoplasmic reticulum (ER) stress and apoptosis are associated with chronic inflammation and cancer progression ...
Wang Xiao, Rong-Chang Cao, Wan-Jun Yang, Jie-Hui Tan, Ruo-Qi Liu, He-Ping Kan, Lei Zhou, Na Zhang, Zhi-Ye Chen, Xue-Mei Chen, Jia Xu, Guo-Wei Zhang, Peng Shen   +12 more
doaj   +4 more sources

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors [PDF]

Cells, 2022
The extracellular aggregation of destabilized transthyretin (TTR) variants is implicated in the onset and pathogenesis of familial TTR-related amyloid diseases.
Jaleh S. Mesgarzadeh, Isabelle C. Romine, Ethan M. Smith-Cohen, Julia M. D. Grandjean, Jeffery W. Kelly, Joseph C. Genereux, R. Luke Wiseman   +6 more
doaj   +3 more sources

Involvement of ATF6 in Octreotide-Induced Endothelial Barrier Enhancement

Pharmaceuticals
Background/Objectives: Endothelial hyperpermeability is the hallmark of severe disease, including sepsis and acute respiratory syndrome (ARDS). The development of medical countermeasures to treat the corresponding illness is of utmost importance ...
Saikat Fakir, Nektarios Barabutis
doaj   +4 more sources

Beneficial effects of neuronal ATF6 activation in permanent ischemic stroke

Frontiers in Cellular Neuroscience, 2022
Objective: Brain ischemia leads to the accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) lumen and consequently, ER stress. To help cells restore ER function, a series of adaptive stress response pathways, collectively termed ...
Xuan Li, Ran Li, Liping Lu, Ashis Dhar, Huaxin Sheng, Wei Yang   +5 more
doaj   +4 more sources

ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response [PDF]

iScience, 2020
Summary: The unfolded protein response (UPR) pathway senses unfolded proteins and regulates proteostasis and cell fate through activity of the transcription factors ATF4, ATF6, and XBP1 within a complex network of three main branches.
Huan Yang, Marije Niemeijer, Bob van de Water, Joost B. Beltman   +3 more
doaj   +6 more sources

BiP Binding Keeps ATF6 at Bay [PDF]

Developmental Cell, 2002
A study by, in this issue of Developmental Cell shows that transport to the Golgi complex and subsequent proteolytic activation of the stress-regulated transcription factor ATF6 is initiated by the dissociation of the ER chaperone BiP from ATF6. This demonstrates that BiP is a key element in sensing the folding capacity within the ER and provides ...
Thomas Sommer, Ernst Jarosch
openalex   +4 more sources

ATF6 as a Nodal Regulator of Proteostasis in the Heart [PDF]

Frontiers in Physiology, 2020
Proteostasis encompasses a homeostatic cellular network in all cells that maintains the integrity of the proteome, which is critical for optimal cellular function. The components of the proteostasis network include protein synthesis, folding, trafficking,
Christopher C. Glembotski, Adrian Arrieta, Erik A. Blackwood, Winston T. Stauffer   +3 more
doaj   +3 more sources

ATF6 modulates SREBP2-mediated lipogenesis [PDF]

The EMBO Journal, 2008
Activating transcription factor 6 (ATF6) and sterol regulatory element-binding proteins (SREBPs) are activated by proteolytic cleavage. The ensuing nuclear translocation of their N-termini (i.e., ATF6(N) and SREBP(N)) activates the respective target genes involved in unfolded protein response and lipogenesis.
Lingfang Zeng, Min Lu, Kazutoshi Mori, Shengzhan Luo, Amy S. Lee, Yi Zhu, John Y.‐J. Shyy   +6 more
openalex   +7 more sources

Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

Journal of Biological Chemistry, 2000
ATF6 is a member of the basic-leucine zipper family of transcription factors. It contains a transmembrane domain and is located in membranes of the endoplasmic reticulum. ATF6 has been implicated in the endoplasmic reticulum (ER) stress response pathway since it can activate expression of GRP78 and other genes induced by the ER stress response.
Yan Wang, Jingshi Shen, Natalia Arenzana, Witoon Tirasophon, Randal J. Kaufman, Ron Prywes   +5 more
openalex   +4 more sources