Results 1 to 10 of about 28,738 (248)

Cancer cell-derived migrasomes harboring ATF6 promote breast cancer brain metastasis via endoplasmic reticulum stress-mediated disruption of the blood-brain barrier [PDF]

Cancer Biology & Medicine
Objective: Migrasomes, an emerging class of migration-facilitating membranous extracellular vesicles, remain largely uncharted in the intricate landscape of tumor metastasis.
Song Wang, Guohao Gu, Xinmiao Xian, Jun Li, Di Zhang, Jianran Guo, Anqi Zhang, Shen Chen, Dong Yan, Bingwu Yang, Meng An, Wei Zhang, Bo Fu   +12 more
doaj   +2 more sources

miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6. [PDF]

, 2015
Background MicroRNA (miRNA) and messenger RNA (mRNA) expression differs in cystic fibrosis (CF) versus non-CF bronchial epithelium. Here, the role of miRNA in basal regulation of the transcription factor ATF6 was investigated in bronchial epithelial ...
Agrawal, Raman, Greene, Catherine M, Mall, Marcus A, McElvaney, Noel G, Oglesby, Irene K   +4 more
core   +4 more sources

ATF6 and pS6K as prognostic biomarkers in newly diagnosed diffuse large B-cell lymphoma [PDF]

Scientific Reports
This study aimed to investigate the clinical and prognostic significance of activating transcription factor 6 (ATF6) and phosphorylated S6 kinase (pS6K) expression in newly diagnosed diffuse large B-cell lymphoma (DLBCL).
Shuang Su, Lili Wu, Chen Huang, Lianjing Wang, Weijing Li, Wei Liu, Lihong Liu   +6 more
doaj   +2 more sources

Targeting ATF6 reduces pathological neovascularization and improves visual outcomes in retinal disease models [PDF]

Scientific Reports
Pathological retinal neovascularization is a cause of vision loss in diseases including retinopathy of prematurity (ROP), wet age-related macular degeneration (AMD), and diabetic retinopathy. The Unfolded Protein Response (UPR) is an intracellular signal
Allyssa Bradley, Soyoung Park, Soyeon Park, Kyle Kim, Angela Galdamez, Hyejung Min, Monica Sophia Diaz-Aguilar, M. Elizabeth Hartnett, Eun-Jin Lee, Jonathan H. Lin   +9 more
doaj   +2 more sources

Activation of TRIM37 by ATF6 and degradation of ACSL4: inhibiting ferroptosis and propelling cervical cancer progression [PDF]

Hereditas
Background Cervical cancer (CC), a prevalent gynecological malignancy, shows high global incidence and mortality. Tripartite motif-containing 37 (TRIM37), a significant ubiquitinating enzyme, is overexpressed in CC, fueling its progression, but its role ...
Yang Wang, Li Xie, Shiying Jin, YouXiang Hou, Yina Wang   +4 more
doaj   +2 more sources

Genetic Variants in the ATF6 Gene and Their Relationship with Milk-Quality Traits in Yaks. [PDF]

Animals (Basel)
Ma X, Guo X, La Y, Wu X, Chu M, Bao P, Yan P, Liang C.   +7 more
europepmc   +3 more sources

TBX5-AS1 induces ER stress and suppresses lung cancer growth and tumor stemness via the miR-494-3p/ATF6 axis. [PDF]

Cell Stress Chaperones
Wang G, Fu C, Tu C, Yang Z, Shi W, Zhang L, Tan S, Huang Y.   +7 more
europepmc   +2 more sources

Activating transcription factor 6 promotes proliferation, migration and invasion of PC3 human prostate cancer cells through Hippo-YAP signaling pathway

陆军军医大学学报, 2023
Objective To investigate the effects of activating transcription factor 6 (ATF6) on the proliferation, migration and invasion of prostate cancer PC3 cells.
LIU Hengchuan, YANG Zongke, LIU Qingyuan, ZHANG Jindong, ZHU Huixuan, WANG Delin   +5 more
doaj   +1 more source

Activating transcription factor (ATF) 6 upregulates cystathionine β synthetase (CBS) expression and hydrogen sulfide (H2S) synthesis to ameliorate liver metabolic damage

European Journal of Medical Research, 2023
Activating transcription factor 6 (ATF6) is an endoplasmic reticulum stress responsive gene. We previously reported that conditional knockout of hepatic ATF6 exacerbated liver metabolic damage by repressing autophagy through mTOR pathway.
Bingzi Dong, Ying Sun, Bingfei Cheng, Yu Xue, Wei Li, Xiaofang Sun   +5 more
doaj   +1 more source

ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes

iScience, 2021
Summary: Although angiogenesis-osteogenesis coupling is important in ankylosing spondylitis (AS), therapeutic agents targeting the vasculature remain elusive.
Mengjun Ma, Hongyu Li, Peng Wang, Wen Yang, Rujia Mi, Jiahao Zhuang, Yuhang Jiang, Yixuan Lu, Xin Shen, Yanfeng Wu, Huiyong Shen   +10 more
doaj   +1 more source