Results 11 to 20 of about 28,738 (248)
Mineral trioxide aggregate induces osteoblastogenesis via Atf6
Bone Reports, 2015 Mineral trioxide aggregate (MTA) has been recommended for various uses in endodontics. To understand the effects of MTA on alveolar bone, we examined whether MTA induces osteoblastic differentiation using MC3T3-E1 cells.
Toyonobu Maeda +5 more
doaj +3 more sources
ATF6 as a Nodal Regulator of Proteostasis in the Heart [PDF]
Frontiers in Physiology, 2020 Proteostasis encompasses a homeostatic cellular network in all cells that maintains the integrity of the proteome, which is critical for optimal cellular function. The components of the proteostasis network include protein synthesis, folding, trafficking,
Christopher C. Glembotski +3 more
doaj +3 more sources
Characterization of Retinal Structure in ATF6-Associated Achromatopsia. [PDF]
Investigative Opthalmology & Visual Science, 2019 PurposeMutations in six genes have been associated with achromatopsia (ACHM): CNGA3, CNGB3, PDE6H, PDE6C, GNAT2, and ATF6. ATF6 is the most recent gene to be identified, though thorough phenotyping of this genetic subtype is lacking.
Carroll, Joseph +16 more
core +7 more sources
A lifetime of stress: ATF6 in development and homeostasis [PDF]
Journal of Biomedical Science, 2018 Background Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors.
Robert F. Hillary, Una FitzGerald
doaj +4 more sources
Multiexon deletion alleles of ATF6 linked to achromatopsia [PDF]
JCI Insight, 2020 Achromatopsia (ACHM) is an autosomal recessive disease that results in severe visual loss. Symptoms of ACHM include impaired visual acuity, nystagmus, and photoaversion starting from infancy; furthermore, ACHM is associated with bilateral foveal hypoplasia and absent or severely reduced cone photoreceptor function on electroretinography.
Eun-Jin Lee +18 more
openalex +5 more sources
Coordination of ATF6-mediated Transcription and ATF6 Degradation by a Domain That Is Shared with the Viral Transcription Factor, VP16 [PDF]
Journal of Biological Chemistry, 2002 ATF6 is a 670-amino acid endoplasmic reticulum (ER) transmembrane protein that is cleaved in response to ER stress. The resulting N-terminal fragment of approximately 400 amino acids translocates to the nucleus and activates selected ER stress-inducible genes, such as GRP-78 and sarco/endoplasmic reticulum ATPase, which are required for cell survival ...
Donna J. Thuerauf +3 more
openalex +4 more sources
Involvement of ATF6 in Octreotide-Induced Endothelial Barrier Enhancement
PharmaceuticalsBackground/Objectives: Endothelial hyperpermeability is the hallmark of severe disease, including sepsis and acute respiratory syndrome (ARDS). The development of medical countermeasures to treat the corresponding illness is of utmost importance ...
Saikat Fakir, Nektarios Barabutis
doaj +3 more sources
Pathomechanisms of ATF6-Associated Cone Photoreceptor Diseases
, 2019 Activating transcription factor 6 (ATF6) is a key regulator of the unfolded protein response (UPR). In response to endoplasmic reticulum (ER) stress, ATF6 is transported from the ER to the Golgi apparatus where it is cleaved by intramembrane proteolysis, releasing its cytosolic fragment. The cleaved ATF6 fragment, which is a basic leucine zipper (bZip)
Wei‐Chieh Chiang +3 more
openalex +5 more sources
Manipulation of the Unfolded Protein Response by Intracellular Bacterial Pathogens: Mechanisms of ER Hijacking and Therapeutic Implications. [PDF]
FASEB JThis review illustrates how intracellular bacterial pathogens—such as Brucella, Mycobacterium tuberculosis, and Legionella—secrete effector proteins that specifically target the IRE1α, PERK, and ATF6 branches of the unfolded protein response (UPR) to hijack ER stress signaling.
Dai E +5 more
europepmc +2 more sources