Cancer cell-derived migrasomes harboring ATF6 promote breast cancer brain metastasis via endoplasmic reticulum stress-mediated disruption of the blood-brain barrier [PDF]
Cancer Biology & MedicineObjective: Migrasomes, an emerging class of migration-facilitating membranous extracellular vesicles, remain largely uncharted in the intricate landscape of tumor metastasis.
Song Wang +12 more
doaj +2 more sources
Characterization of Retinal Structure in ATF6-Associated Achromatopsia [PDF]
Investigative Opthalmology & Visual Science, 2019 Mutations in six genes have been associated with achromatopsia (ACHM): CNGA3, CNGB3, PDE6H, PDE6C, GNAT2, and ATF6. ATF6 is the most recent gene to be identified, though thorough phenotyping of this genetic subtype is lacking. Here, we sought to test the hypothesis that ATF6-associated ACHM is a structurally distinct form of congenital ACHM.Seven ...
Michalis Georgiou +21 more
openaire +9 more sources
ERVW-1 Activates ATF6-Mediated Unfolded Protein Response by Decreasing GANAB in Recent-Onset Schizophrenia [PDF]
Viruses, 2023 Schizophrenia, a mental disorder, afflicts 1% of the worldwide population. The dysregulation of homeostasis in the endoplasmic reticulum (ER) has been implicated in schizophrenia.
Xing Xue +4 more
semanticscholar +2 more sources
Transcriptional Factor ATF6 is Involved in Odontoblastic Differentiation [PDF]
Journal of Dental Research, 2014 ATF6 is an endoplasmic reticulum (ER) membrane-bound transcription factor that regulates various cellular functions. The purpose of this study was to investigate the role of ATF6 in odontoblast differentiation. Rat tooth germs were isolated, changes in gene expression were evaluated over time, and localization of ATF6 was determined by ...
J.W. Kim +9 more
openalex +3 more sources
ATF6 is essential for human cone photoreceptor development
Proceedings of the National Academy of Sciences, 2021 Significance Inactivating genetic variants in the Unfolded Protein Response (UPR) regulator Activating Transcription Factor 6 (ATF6) result in loss of color vision, which is linked to dysfunctional cone photoreceptors and the development of achromatopsia.
H. Kroeger +13 more
semanticscholar +5 more sources
Mitotic regulation of SREBP and ATF6 by separation of the Golgi and ER [PDF]
Cell Cycle, 2008 The highly organized structure of the Golgi apparatus becomes compromised during mitosis. The Golgi cisternae unstack and form vesicles, which are then partitioned into the daughter cells. Here, we analyzed the fate of the SREBP and ATF6, two key transcription factors of sterol biogenesis and the unfolded protein response, respectively.
René Bartz, Joachim Seemann
openalex +4 more sources
ATF6 activation promotes tumorigenesis and drug resistance in diffuse large B-cell lymphoma (DLBCL) by regulating the mTOR/S6K signaling pathway [PDF]
Discover OncologyThis study analyzes the expression and functional role of activating transcription factor 6 (ATF6) in diffuse large B-cell lymphoma (DLBCL) and its effects on disease progression.
Shuang Su +7 more
doaj +2 more sources
Dependence of Site-2 Protease Cleavage of ATF6 on Prior Site-1 Protease Digestion Is Determined by the Size of the Luminal Domain of ATF6 [PDF]
Journal of Biological Chemistry, 2004 ATF6 is an endoplasmic reticulum (ER) membrane-anchored transcription factor activated by regulated intramembrane proteolysis in the ER stress response. The release of the cytosolic transcription factor domain of ATF6 requires the sequential processing by the Golgi site-1 and site-2 proteases (S1P and S2P).
Jingshi Shen, Ron Prywes
openalex +4 more sources
Scientific Reports, 2021 Retinitis Pigmentosa (RP) is a blinding disease that arises from loss of rods and subsequently cones. The P23H rhodopsin knock-in (P23H-KI) mouse develops retinal degeneration that mirrors RP phenotype in patients carrying the orthologous variant ...
Eun-Jin Lee +5 more
doaj +2 more sources
AA147 ameliorates post-cardiac arrest cerebral ischemia/reperfusion injury through the co-regulation of the ATF6 and Nrf2 signaling pathways [PDF]
Frontiers in Pharmacology, 2022 Ischemia/reperfusion caused by cardiac arrest (CA) disturbs endoplasmic reticulum (ER) homeostasis and redox balance in neurons. AA147, originally developed as a pharmacologic activator of the activating transcription factor 6 (ATF6), can protect ...
Z. Yuan +7 more
semanticscholar +2 more sources