Results 21 to 30 of about 29,072 (277)

ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress

Cell Death Discovery, 2022
Colon cancer represents one of the most common and aggressive cancers in its advanced state. Among the most innovative anti-cancer approaches, the manipulation of UPR is a promising one, effective also against cancers carrying dysfunctional p53 ...
Rossella Benedetti, Maria Anele Romeo, Andrea Arena, Maria Saveria Gilardini Montani, Livia Di Renzo, Gabriella D’Orazi, Mara Cirone   +6 more
doaj   +2 more sources

Molecular mechanism of ATF6 in unfolded protein response and its role in disease

Heliyon
Activating transcription factor 6 (ATF6), an important signaling molecule in unfolded protein response (UPR), plays a role in the pathogenesis of several diseases, including diseases such as congenital retinal disease, liver fibrosis and ankylosing ...
Yingying Lei, Hong Yu, Shaoxue Ding, Hui Liu, Chunyan Liu, Rong Fu   +5 more
doaj   +2 more sources

IL-6/STAT3 Induced Neuron Apoptosis in Hypoxia by Downregulating ATF6 Expression

Frontiers in Physiology, 2021
Background: Neuron apoptosis, regulated by endoplasmic reticulum (ER) stress in the hippocampus, is an essential factor influencing the cognitive impairment induced by hypobaric hypoxia.
Simin Zhou, Simin Zhou, Simin Zhou, Zhifeng Zhong, Zhifeng Zhong, Zhifeng Zhong, Pei Huang, Pei Huang, Pei Huang, Bin Xiang, Bin Xiang, Bin Xiang, Xiaoxu Li, Xiaoxu Li, Xiaoxu Li, Huaping Dong, Huaping Dong, Huaping Dong, Gang Zhang, Gang Zhang, Gang Zhang, Yu Wu, Yu Wu, Yu Wu, Peng Li, Peng Li, Peng Li   +26 more
doaj   +2 more sources

Macrophage ATF6 accelerates corticotomy-assisted orthodontic tooth movement through promoting Tnfα transcription [PDF]

International Journal of Oral Science
Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon (RAP). Despite its therapeutic effects, the surgical risk and unclear mechanism hamper the clinical application.
Zhichun Jin, Hao Xu, Weiye Zhao, Kejia Zhang, Shengnan Wu, Chuanjun Shu, Linlin Zhu, Yan Wang, Lin Wang, Hanwen Zhang, Bin Yan   +10 more
doaj   +2 more sources

Lycium barbarum polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism

Acta Biochimica et Biophysica Sinica
Lipid droplets (LDs) are dynamic organelles that store neutral lipids and are closely linked to obesity. Previous studies have suggested that Lycium barbarum polysaccharide (LBP) supplements can ameliorate obesity, but the underlying
Zhou Rui, Liu Yajing, Hu Weiqian, Yang Jing, Lin Bing, Zhang Zhentian, Chen Mingyan, Yi Jingwen, Zhu Cuifeng   +8 more
doaj   +2 more sources

Mineral trioxide aggregate induces osteoblastogenesis via Atf6

Bone Reports, 2015
Mineral trioxide aggregate (MTA) has been recommended for various uses in endodontics. To understand the effects of MTA on alveolar bone, we examined whether MTA induces osteoblastic differentiation using MC3T3-E1 cells.
Toyonobu Maeda, Atsuko Suzuki, Satoshi Yuzawa, Yuh Baba, Yuichi Kimura, Yasumasa Kato   +5 more
doaj   +3 more sources

Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Ischemia/reperfusion injury impairs proteostasis, and triggers adaptive cellular responses, such as the unfolded protein response (UPR), which functions to restore endoplasmic reticulum homeostasis. After cardiac arrest (CA) and resuscitation,
Yuntian Shen, Ran Li, Shu Yu, Qiang Zhao, Zhuoran Wang, Huaxin Sheng, Wei Yang   +6 more
doaj   +2 more sources

Transmission of ER stress response by ATF6 promotes endochondral bone growth [PDF]

Journal of Orthopaedic Surgery and Research, 2015
We reported earlier that X-box binding protein1 spliced (XBP1S), a key regulator of the unfolded protein response (UPR), as a bone morphogenetic protein 2 (BMP2)-inducible transcription factor, positively regulates endochondral bone formation by activating granulin-epithelin precursor (GEP) chondrogenic growth factor.
Zhangyuan Xiong, Rong Jiang, Peng Zhang, Xiaofeng Han, Fengjin Guo   +4 more
openalex   +5 more sources

The Unfolded Protein Response Regulator, ATF6, Promotes Mesodermal Differentiation [PDF]

The FASEB Journal, 2018
ATF6 encodes a transcription factor that is activated during the Unfolded Protein Response to protect cells from ER stress. Loss of ATF6α and its paralog ATF6β, results in embryonic lethality, notochord dysgenesis, and in people, loss of ATF6α specifically, results in malformed neuroretina and congenital vision loss.
Heike Kroeger, Neil Grimsey, Ryan J Paxman, Wei‐Chieh Chiang, Lars Plate, Ying Jones, Peter X. Shaw, JoAnn Trejo, Stephen H. Tsang, Evan T. Powers, Jeffery W. Kelly, R. Luke Wiseman, Jonathan H. Lin   +12 more
openalex   +7 more sources

Repaglinide Induces ATF6 Processing and Neuroprotection in Transgenic SOD1G93A Mice

International Journal of Molecular Sciences, 2023
: The interaction of the Activating Transcription Factor 6 (ATF6), a key effector of the unfolded protein response (UPR) in the endoplasmic reticulum, with the neuronal calcium sensor Downstream Regulatory Element Antagonist Modulator (DREAM) is a potential therapeutic target in neurodegeneration.
Rafael Gonzalo‐Gobernado, Laura Moreno‐Martínez, Paz González, Xosé M. Dopazo, Ana Cristina Calvo, I Guevara, Elisa Seisdedos, Rodrigo Díaz-Muñoz, Britt Mellström, Rosario Osta, José R. Naranjo   +10 more
openalex   +4 more sources