Results 31 to 40 of about 29,072 (277)

QRICH1 regulates ATF6 transcription to affect pathological cardiac hypertrophy progression [PDF]

Molecular Medicine
Background Many studies have shown that pathological cardiac hypertrophy is associated with active endoplasmic reticulum (ER) stress. Glutamine-rich protein 1 (QRICH1), as a transcriptional regulator, belongs to the caspase recruitment domain (CARD ...
Lihui Zhang, Hongping Chen, Guangmei Zou, Wenjuan Jia, Haibin Dong, Chunxiao Wang, Hua Wang, Yugang Liu, Da Teng, Bowen Xu, Lin Zhong, Lei Gong, Jun Yang   +12 more
doaj   +2 more sources

Activation of TRIM37 by ATF6 and degradation of ACSL4: inhibiting ferroptosis and propelling cervical cancer progression [PDF]

Hereditas
Background Cervical cancer (CC), a prevalent gynecological malignancy, shows high global incidence and mortality. Tripartite motif-containing 37 (TRIM37), a significant ubiquitinating enzyme, is overexpressed in CC, fueling its progression, but its role ...
Yang Wang, Li Xie, Shiying Jin, YouXiang Hou, Yina Wang   +4 more
doaj   +2 more sources

ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy–Dependent Pathway

Frontiers in Immunology, 2021
Antigen (Ag)-mediated mast cell activation plays a critical role in the immunopathology of IgE-dependent allergic diseases. Restraining the signaling cascade that regulates the release of mast cell-derived inflammatory mediators is an attractive ...
Jia Li, Md Ashik Ullah, Hongping Jin, Yuting Liang, Lihui Lin, Juan Wang, Xia Peng, Huanjin Liao, Yanning Li, Yiqin Ge, Li Li   +10 more
doaj   +2 more sources

Pathomechanisms of ATF6-Associated Cone Photoreceptor Diseases

, 2019
Activating transcription factor 6 (ATF6) is a key regulator of the unfolded protein response (UPR). In response to endoplasmic reticulum (ER) stress, ATF6 is transported from the ER to the Golgi apparatus where it is cleaved by intramembrane proteolysis, releasing its cytosolic fragment. The cleaved ATF6 fragment, which is a basic leucine zipper (bZip)
Wei‐Chieh Chiang, Heike Kroeger, Lulu Chea, Jonathan H. Lin   +3 more
openalex   +5 more sources

Tumor-associated macrophages confer colorectal cancer 5-fluorouracil resistance by promoting MRP1 membrane translocation via an intercellular CXCL17/CXCL22–CCR4–ATF6–GRP78 axis

Cell Death and Disease, 2023
Chemotherapy represents a major type of clinical treatment against colorectal cancer (CRC). Aberrant drug efflux mediated by transporters acts as a key approach for tumor cells to acquire chemotherapy resistance.
Lichao Zhang, Xiaoqing Lu, Yuanzhi Xu, Xiaoqin La, Jinmiao Tian, Aiping Li, Hanqing Li, Changxin Wu, Yanfeng Xi, Guisheng Song, Zhaocai Zhou, Wenqi Bai, Liwei An, Zhuoyu Li   +13 more
semanticscholar   +1 more source

Activating transcription factor 6 promotes proliferation, migration and invasion of PC3 human prostate cancer cells through Hippo-YAP signaling pathway

陆军军医大学学报, 2023
Objective To investigate the effects of activating transcription factor 6 (ATF6) on the proliferation, migration and invasion of prostate cancer PC3 cells.
LIU Hengchuan, YANG Zongke, LIU Qingyuan, ZHANG Jindong, ZHU Huixuan, WANG Delin   +5 more
doaj   +1 more source

Activating transcription factor (ATF) 6 upregulates cystathionine β synthetase (CBS) expression and hydrogen sulfide (H2S) synthesis to ameliorate liver metabolic damage

European Journal of Medical Research, 2023
Activating transcription factor 6 (ATF6) is an endoplasmic reticulum stress responsive gene. We previously reported that conditional knockout of hepatic ATF6 exacerbated liver metabolic damage by repressing autophagy through mTOR pathway.
Bingzi Dong, Ying Sun, Bingfei Cheng, Yu Xue, Wei Li, Xiaofang Sun   +5 more
doaj   +1 more source

Multiexon deletion alleles of ATF6 linked to achromatopsia [PDF]

JCI Insight, 2020
Achromatopsia (ACHM) is an autosomal recessive disease that results in severe visual loss. Symptoms of ACHM include impaired visual acuity, nystagmus, and photoaversion starting from infancy; furthermore, ACHM is associated with bilateral foveal hypoplasia and absent or severely reduced cone photoreceptor function on electroretinography.
Heike Kroeger, Heike Kroeger, Susanne Kohl, Stephen H. Tsang, Daniel L. Chao, Julia M. D. Grandjean, Rebecca Mastey, Britta Baumann, Anthony T. Moore, Jonathan H. Lin, Jonathan H. Lin, Isabelle Audo, Isabelle Audo, Wei-Chieh Chiang, Wei-Chieh Chiang, Chloe Xiaoke Bi, Dorota Skowronska-Krawczyk, Kyle Kim, Scott R. Lambert, Leon Chea, R. Luke Wiseman, Joseph Carroll, Eun-Jin Lee, Eun-Jin Lee   +23 more
openaire   +4 more sources

Protocadherin 20 maintains intestinal barrier function to protect against Crohn’s disease by targeting ATF6

Genome Biology, 2023
Background Intestinal barrier dysfunction plays a central role in the pathological onset of Crohn’s disease. We identify the cadherin superfamily member protocadherin 20 (PCDH20) as a crucial factor in Crohn’s disease.
Shanshan Huang, Zhuo Xie, Jing Han, Huiling Wang, Guang Yang, Man-ying Li, Gaoshi Zhou, Ying Wang, Lixuan Li, Li Li, Z. Zeng, Jun Yu, Minhu Chen, Shenghong Zhang   +13 more
semanticscholar   +1 more source

Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis

Cells, 2020
The heart exhibits incredible plasticity in response to both environmental and genetic alterations that affect workload. Over the course of development, or in response to physiological or pathological stimuli, the heart responds to fluctuations in ...
Erik A. Blackwood, Alina S. Bilal, Winston T. Stauffer, Adrian Arrieta, Christopher C. Glembotski   +4 more
doaj   +1 more source